Aspects of thermal conductivity relative to heat flow

Summary The various techniques and methodologies of thermal conductivity measurement have been conventionally based on the determination of the rate of directional heat flow through a material having a unit temperature differential between its opposing faces. The constancy of this rate depends on the material density, its thermal resistance and the heat flow path itself. The last of these variables contributes most significantly to the true value of steady-state axial and radial heat dissipation depending on the magnitude of transient thermal diffusivity along these directions. The purpose of this paper is to exemplify the above features by defined parameters of heat flow measurement by existing methodologies. No new method is proposed here. Importantly, the relationship between the rate of heat transfer, total heat transferred and thermal conductivity at a given temperature under steady-state conditions for a fixed heat flow path will be illustrated.     

Synthesis and in Vitro Evaluation of N-[[4-[2-(Carboxyl)-1-Cycloalken-1-yl]Phenyl]Methyl]Imidazoles as Nonpeptide Angiotensin II Receptor Antagonists

A series of nonpeptide angiotensin II receptor antagonists was synthesized via palladium-assisted cross coupling of aryl stannane and cycloalkenyl triflates and subsequent alkylation of silyl-protected imidazole. Our compounds, which have a terminal five- to seven-membered cycloalkenyl ring, are compared to DuPont EXP7711, an N-[(2′-carboxybiphenylyl)methyl]imidazole, which has a terminal phenyl moiety. Physicochemical properties of the compounds, such as lipophilicity, steric bulk, conformation, and the relative spatial proximity of the 2-carboxyl and the middle phenyl, are quantitated by computational chemistry. Potency in terms of binding affinity to AT₁ receptors in rat adrenal glomerulosa and rabbit aorta is maximized when the terminal ring is aromatic.     

Profitability in the car industry: New measures for estimating targets and target directions

In this paper we study the profitability of car manufacturers in relation to industry-wide profitability targets such as industry averages. Specifically we are interested in whether firms adjust their profitability in the direction of these targets, whether it is possible to detect any such change, and, if so, what the precise nature is of these changes.     

pePC-SAFT: Modeling of polyelectrolyte systems: 1. Vapor–liquid equilibria

A molecular thermodynamic model for polyelectrolyte systems—called pePC-SAFT—is proposed. The effect of charged monomers within the polyelectrolyte chain is explicitly taken into account in the reference term by replacing the hard-chain contribution of the PC-SAFT model by a charged-hard-chain contribution. Moreover, counterion condensation is accounted for to determine the effective number of charges along the polyion as well as of free counterions. The electrostatic contribution of the free counterions is described by a Debye–Hückel term.     

Large Deviations of Queues Sharing a Randomly Time-Varying Server

We consider a discrete-time model where multiple queues, each with its own exogenous arrival process, are served by a server whose capacity varies randomly and asynchronously with respect to different queues. This model is primarily motivated by the problem of efficient scheduling of transmissions of multiple data flows sharing a wireless channel. We address the following problem of controlling large deviations of the queues: find a scheduling rule, which is optimal in the sense of maximizing

Preparation and properties of an antibody-selective membrane electrode

A membrane electrode with selective response for the antibodies of the antigenic determinant dinitrophenol (DNP) has been devised by incorporating DNP—ion carrier conjugates in a polyvinyl chloride membrane matrix. Details of the preparative and immobilization procedures are provided along with an evaluation of optimum solution conditions for electrode use. The response mechanism of the antibody electrode is postulated to involve a “selectivity shift” effect.     

Simultaneous determination of losartan and active metabolite EXP3174 in rat plasma by HPLC with column switching

Summary A new liquid chromatographic method with columnswitching has been developed for the simultaneous determination of losartan and its active metabolite, EXP3174 in rat plasma. The plasma samaple was injected onto a precolumn of Lichroprep RP-8 after dilution with 5% acetonitrile in 50 mM phosphoric acid. Polar plasma components were eluted using this diluent. After valve switching, the concentrated drugs were eluted in the back-flush mode and separated by an Inertsil ODS-2 column with acetonitrile-acetate buffer. The method showed excellent precision, accuracy and speed with detection limit 20 ng mL^–1. Total analysis time per sample was less than 40 min and the coefficients of variation for intra and inter-assay were 4.8%. This method has been successfully applied after oral administration of losartan to rat plasma samples.     

Comparative study of efficiency and reproducibility of two high-performance gel permeation chromatography columns with microparticulate packings

Two kinds of commercially available, microparticulate silica columns have been studied for their efficiency and reproducibility in gel permeation chromatography measurements. Results are provided for column plate height measurements, dispersity, and specific resolution as a function of flow rate. The influence of injection volume and slice width on these measurements is also presented. Reproducibility studies on polystyrene and styrene-n-butyl methacrylate copolymer are reported.