Spectrophotometric Determination of Diphenadione Via its Metal Complexes

Abstract

Spectrophotometric procedure is described for the quantitative determination of diphenadione [2-(diphenylacetyl)-1,3-indandione], based on direct spectrophotometric measurements of the absorbances of its iron (III), iron (II) and cobalt (II), metal complexes at 488 nm, 505 nm and (334 nm, 372 nm), respectively. The drug reacts with metals in the ratio of 3:1 and 2:1 for iron (III) and for both iron (II) and cobalt (II) respectively. The obtained complexes have apparent molar absorptivities of 1.48 × 10³ 1 mol^?1 cm^?1, 0.714 × 10³ 1 mol^?1cm^?1 and (1.70 × 10³ 1 mol^?1cm^?1, 1.93 × 10³ 1 mol^?1cm^?1) for iron (III), iron (II) and cobalt (II) complexes, respectively. The procedure is suggested for the determination of 51–400 μg.ml^?1 diphenadione via the iron (II) complex and 35–170 μg.ml^?1 diphenadione via both cobalt (II) and iron (III) complexes. The suggested procedure has accuracies of 99.79 ± 0.67%, 99.64 ± 0.37% and (100.09 ± 0.53%, 99.99 ± 0.42%) for the metal complexes of iron (III), iron (II) and cobalt (II), respectively.     

金属配位模板聚合物的分子识别特性的研究

以Ｃｏ（Ⅱ）和敌鼠配合物为模板,４－乙烯吡啶为功能基单体,乙二醇二甲基丙烯酸酯为交联剂,采用分子印迹技术,合成了具有类似于金属螯合抗体结合位点的金属配位模板聚合物。系统研究了金属离子对模板聚合物靠拢性结构敌鼠的调节作用。