A High Yielding, One-Pot, Triton-B Catalyzed, Expeditious Synthesis of Carbamate Esters by Four Component Coupling Methodology

Summary. A novel process for the one-step chemoselective conversion of alkyl halides into carbamates as protected amines was developed using benzyltrimethylammonium hydroxide (Triton-B) in presence of gaseous carbon dioxide. Thus, carbamate esters of different amines were prepared in very good to excellent yields. Present address: Institute of Organic and Biomolecular Chemistry, George–August University, 37077, G?ttingen, Germany     

4－二甲氨基吡啶的合成及其催化的有机反应

综述了４－二甲氨基吡啶（ＤＭＡＰ）的制备方法及其对酰化、酯交换、烷基化等有机反应的催化作用，并探讨其在精细化工诸领域的应用前景。参考文献５０篇。     

4-二甲基氨基吡啶催化合成N-保护氨基酸三氟乙酯

合成了6个未见文献报道的N-保护氨基酸三氟乙酯。4-二甲基氨基吡啶对N-保护氨基酸三氟乙酯的合成具有较高的催化活性,使三氟乙酯的合成产率大大增加。     

DMAP-catalyzed cascade reaction: one-pot synthesis of benzofurans in water

A series of benzofurans were efficiently synthesized in good to excellent yields using 4-dimethylaminopyridine (DMAP) catalyzed cascade reaction between salicylaldehydes and halogenated ketones in water at 80 °C opened atmosphere.     

Synthesis of complex dispirocyclopentanebisoxindoles via cycloaddition reactions of 4-dimethylamino-1-alkoxycarbonylmethylpyridinium bromides with 2-oxoindolin-3-ylidene derivatives

The cycloaddition reactions of 4-dimethylamino-1-alkoxycarbonylmethylpyridinium bromides with various 2-oxoindolin-3-ylidene derivatives in ethanol in the presence of triethylamine afforded the unprecedented dispirocyclopentanebisoxindole derivatives in good yields and in high diastereoselectivity. Under similar reaction conditions, the reactions of 1-alkoxycarbonylmethylpyridinium bromides with 3-phenacylideneoxindoles only resulted in 4-oxo-3-(2-oxoindolin-3-ylidene)-4-arylbutanoates. The stereochemistry of the complex spirooxindoles was established by ¹H NMR data and single crystal structures.