Synthesis of New Thiazine and Thiosemicarbazone Derivatives from D-Xylose

Thioureas have strong antifungal activities1 and their antimicrobial and insecticidal properties have been documented for more than fifty years2. Recently thiourea derivatives have been reported to possess antitubercular, antithyroid and anticancer3 prope…     

Synthesis and characterization of <Emphasis Type="Italic">N</Emphasis>-tolyglycosylamines

N-Tolylglycosylamines were synthesized from o-, m-, and p-toluidines and aldoses (D-glucose, D-galactose, D-mannose, L-rhamnose, D-xylose, and L-arabinose). The anomeric and isomeric compositions of the synthesized products were established using ¹³C NMR methods. __________ Translated from Khimiya Prirodnykh Soedinenii, No. 4, pp. 333–335, July–August, 2008.     

The SARS-CoV-2 Entry Inhibition Mechanisms of Serine Protease Inhibitors,OM-85, Heparin and Soluble HS Might Be Linked to HS Attachment Sites

This article discusses the importance of D-xylose for fighting viruses (especially SARS-CoV-2) that use core proteins as receptors at the cell surface, by providing additional supporting facts that these viruses probably bind at HS/CS attachment sites (i.e., the hydroxyl groups of Ser/Thr residues of the core proteins intended to receive the D-xylose molecules to initiate the HS/CS chains). Essentially, the additional supporting facts, are: some anterior studies on the binding sites of exogenous heparin and soluble HS on the core proteins, the inhibition of the viral entry by pre-incubation of cells with heparin, and additionally, corroborating studies about the mechanism leading to type 2 diabetes during viral infection. We then discuss the mechanism by which serine protease inhibitors inhibit SARS-CoV-2 entry. The biosynthesis of heparan sulfate (HS), chondroitin sulfate (CS), dermatan sulfate (DS), and heparin (Hep) is initiated not only by D-xylose derived from uridine diphosphate (UDP)-xylose, but also bioactive D-xylose molecules, even in situations where cells were previously treated with GAG inhibitors. This property of D-xylose shown by previous anterior studies helped in the explanation of the mechanism leading to type 2 diabetes during SARS-CoV-2 infection. This explanation is completed here by a preliminary estimation of xyloside GAGs (HS/CS/DS/Hep) in the body, and with other previous studies helping to corroborate the mechanism by which the D-xylose exhibits its antiglycaemic properties and the mechanism leading to type 2 diabetes during SARS-CoV-2 infection. This paper also discusses the confirmatory studies of regarding the correlation between D-xylose and COVID-19 severity.     

298.15 K下氨基酸在D-木糖水溶液中的体积性质

报道了甘氨酸、L-丙氨酸和L-丝氨酸3种典型氨基酸在D-木糖水溶液中的体积性质.     

1-甲氧基-3,5-二-O-苄基-β-D-呋喃型核糖苷-2-酮糖的合成

1-甲氧基-3,5-二-O-苄基-β-D-呋喃型核糖苷-2-酮糖是重要的医药中间体.以廉价D-木糖为起始原料,经过9步反应,合成了1-甲氧基-3,5-二-O-苄基-β-D-呋喃型核糖苷-2-酮糖;中间产物不需柱层析分离提纯,可以直接用于下一步反应;各步产物的结构均经核磁共振氢谱和质谱分析确认.     

Synthesis of N-aminoglycosides of the alkaloid cytisine

A series of new N-aminoglycosides of the alkaloid cytisine based on industrially available monosaccharides D-glucose, D-galactose, D-xylose, and L-arabinose was synthesized and characterized. The optimal methods for condensing and isolating the products were found. The structures and position of cytisine in the glycosides were proved by PMR spectroscopy. Translated from Khimiya Prirodnykh Soedinenii, No. 6, pp. 596–597, November–December, 2008.