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Zhiwen Chu Ruiqi Tong Yufan Yang Xuanyi Song Tian bao Hu Yu Fan Chen Zhao Lu Gao Zhenlei Song 《中国化学快报》2021,32(1):1-4
A convergent approach to 1,5-hydroxy ketones,the general precursors for constructing the C ring of bryostatins,has been developed via a Zn/Cu-promoted conjugate addition of a-hydroxy iodides with enones.The reaction leads to direct formation of the C21-C22 bond and tolerates diverse functionalities at the C17-,C18-and C24-positions.The approach also enables a more concise synthesis of the known C ring intermediate(10 longest linear steps and 14 total steps),in contrast to its previous synthesis(17 longest linear steps and 22 total steps) in our total synthesis of bryostatin 8. 相似文献
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Photocatalytic/Cu‐Promoted C−H Activations: Visible‐light‐Induced ortho‐Selective Perfluoroalkylation of Benzamides 下载免费PDF全文
Xiang Chen Prof. Dr. Ze Tan Qingwen Gui Liang Hu Jidan Liu Jing Wu Prof. Guangwei Wang 《Chemistry (Weinheim an der Bergstrasse, Germany)》2016,22(18):6218-6222
A visible‐light‐induced and copper‐promoted perfluoroalkylation of benzamides was successfully developed under the assistance of an 8‐aminoquinoline directing group. It provides a straightforward method for the synthesis of ortho‐perfluoroalkyl‐substituted benzoic acid derivatives. The reaction employs a cheap organic dye eosin Y as the photoredox catalyst and is run under the irradiation of a 26 W fluorescent LED light bulb. 相似文献
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