Amberlyst-15 Catalyzed Cbz Protection of Amines Under Solvent-Free Conditions

Amberlyst-15 can effectively catalyze Cbz protection of aliphatic and aromatic amines within 10–15 min under solvent-free conditions. The catalyst can be used repeatedly without loss of activity, and the reaction requires no workup and gives excellent yields.

Facile Allylation of N‐Boc and N‐Cbz Imines with Allyltrichlorosilane promoted by DMF

Facile allylation of various N‐Boc and N‐Cbz imines with allyltrichlorosilane has been effected using N,N‐dimethylformamide (DMF) as the activator. The N‐Boc and N‐Cbz homoallylic amines were obtained in good to high yields under mild conditions.     

The aza-Wittig reaction: an efficient tool for the construction of carbon-nitrogen double bonds

Recent advances in the aza-Wittig reaction of phosphazene derivatives with several carbonyl compounds are reviewed. Phosphazenes afford inter- and intramolecular aza-Wittig reactions with different compounds such as aldehydes, ketones, esters, thioesters, amides, anhydrides and sulfimides. One of the most important applications of this reaction is the synthesis of a wide range of acyclic and heterocyclic compounds, ranging from simple monocyclic compounds to complex polycyclic and macrocyclic systems.     

Asymmetric catalysis as a method for the synthesis of chiral organophosphorus compounds

This review discusses methods for the metallo-, organo- and biocatalytic asymmetric synthesis of chiral organophosphorus compounds with many applications in stereoselective synthesis with references to updated literature reports as well as the author’s original research. Asymmetric catalytic hydrogenation and reduction with chiral organometallic complexes, together with actively used asymmetric organocatalytic versions of various reactions enable us to synthesize chiral organophosphonates and phosphinates with high enantioselectivity and purity. Asymmetric catalysis is also an effective tool to realize some classic reactions of phosphorus chemistry in a stereospecific manner.