排序方式: 共有14条查询结果,搜索用时 15 毫秒
1.
Florence Chery 《Tetrahedron letters》2004,45(10):2067-2069
The synthesis of an 1-deoxymannojirimycin based analogue of a known HIV-protease inhibitor is described. The strategies employed for introduction of the pharmacophore groups onto the azasugar scaffold were based on regioselective reactions of the hydroxyl groups of the natural product and of d-fructopyranoside derivatives. 相似文献
2.
Ping-Zhu Zhang Hai-Long Yang Cui-Cui Li Zhi-Chao Xia Xiao-Man Wang Hua Wei Rui-Xue Rong Zhi-Ran Cao Ke-Rang Wang Hua Chen Xiao-Liu Li 《中国化学快报》2014,25(7):1057-1059
A series of novel, azasugar-modified 2-monosubstituted, 2,6- and 2,7-bissubstituted anthraquinone derivatives have been synthesized by the nucleophilic substitution of N-alkylamino azasugar with mono-, bis(2-chloroacetamido)anthraquinones. Their cytotoxic activities against HeLa and MCF-7 ceils were preliminarily evaluated and compound 9a with mono-azasugar pendant at 2-position showed similar activity to the control drug (Cisplatin). 相似文献
3.
This paper describes a new synthetic route towards hydroxylated pyrrolidines and azepane derivatives starting from chiral epoxyamides. The alternate transformations on a ribose derivative α,β-epoxyamide permit the construction of five or seven member rings leading to different precursors of homoiminosugars. 相似文献
4.
Hongbin Sun 《Tetrahedron》2005,61(44):10462-10469
Compounds that simultaneously combine charge and conformational features of glycosyltransfer transition states are of interest as transition state analog inhibitors. The synthesis of a central intermediate, cis-3a,6-dihydroxy-hexahydro-cyclopenta[b]pyrrol-2-one, which yielded a family of substituted cis-3a,6-dihydroxy-hexahydro-cyclopenta[b]pyrroles that combine conformational biasing and transition state charge mimicry, is described. The key steps in this synthesis involve synthesis of (2-azido-1,3-dihydroxy-cyclopentyl)-acetic acid ethyl ester in four steps from cyclopentenone, followed by an efficient reductive cyclization of the azide to the bicyclic lactam. The lactam was subsequently converted into the corresponding bicyclic pyrrolidine, and analogs having phenyl, hydroxyl, and phosphate substituents. 相似文献
5.
Florence Chery 《Tetrahedron》2004,60(31):6597-6608
Synthetic routes to peptidomimetic compounds derived from saccharide scaffolds are described. The regioselective introduction of pivaloyl groups was achieved from N-benzyloxycarbonyl protected 1-deoxymannojirimycin or via d-fructopyranosides. The results from biological evaluation of the saccharide derivatives as HIV-protease inhibitors are included. 相似文献
6.
Shigeru Furukubo 《Tetrahedron letters》2004,45(44):8177-8181
A new method using electrochemical oxidation has been exploited for the stereoselective synthesis of 2,3,6-trihydroxylated 5S-piperidine derivatives. The electrochemical method was successively used for the conversion of N-protected piperidines to N-protected 1-methoxypiperidines and for the conversion of 1-methoxy-2,3-didehydropiperidine derivatives to 1,2,3-triacetoxypiperidine derivatives. The method provided a new synthetic route to 2S,3S,6-triacetoxy-5S-methylpiperidine and 2R,3R,6-triacetoxy-5S-methylpiperidine. 相似文献
7.
A general strategy for the synthesis of deoxyazasugars from d-glucose is described. Ring-closing metathesis and stereoselective dihydroxylation reactions were used as key steps. 相似文献
8.
以D-木糖及D-葡萄糖为原料, 经具有降冰片结构的双环缩醛中间体, 合成了适当羟基保护的五元环氮杂糖衍生物及其氟代衍生物, 进一步探讨了含氮杂糖结构的双糖衍生物的合成. 相似文献
9.
Carlos A.D. SousaFabio Rizzo-Aguiar M. Luísa C. ValeXerardo García-Mera Olga CaamañoJosé E. Rodríguez-Borges 《Tetrahedron letters》2012,53(9):1029-1032
A route to selective functionalization of polyhydroxypyrrolidines is described. The method is based on orthogonal protection/deprotection along the process of synthesis of the referred pyrrolidines, which consist in hydroxylation of the double bond of 2-azabicyclo[2.2.1]hept-5-enes followed by its oxidative cleavage and in situ reduction of the intermediate dialdehyde. The synthesis of a novel N-hydroxypyrrolidine is also described. 相似文献
10.
Novel polyhydroxylated indolizidine derivatives containing an amino group have been efficiently and divergently synthesized from azasugar aldehyde. The key steps of the strategy involved an effectively microwave assisted 1,3-dipolar cycloaddition of azasugar nitrone and methacrylate for installing a potential amino group and an ester group with a extended chain, and a structurally controlled intramolecular cyclo-amidation for constructing the indolizidine ring system via a key tricyclic indolizinone-containing intermediate. 相似文献