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1.
《Magnetic resonance in chemistry : MRC》2003,41(12):1034-1037
The assignment of 1H and 13C NMR of the sesquiterpene (+)‐10β,14‐dihydroxy‐allo‐aromadendrane by means of two‐dimensional NMR is reported. Copyright © 2003 John Wiley & Sons, Ltd. 相似文献
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Carlos Alberto Theodoro Siqueira Alessandra Freitas Serain Aislan Cristina Rheder Fagundes Pascoal Nathalia Luiza Andreazza Caroline Caramano de Lourenço Ana Lúcia T. Góis Ruiz 《Natural product research》2015,29(20):1966-1969
Essential oil from the leaves of Guatteria australis was obtained by hydrodistillation, analyzed by Gas Chromatography coupled to Mass Spectromery (GC–MS) and their antiproliferative, antileishmanial, antibacterial, antifungal and antioxidant activities were also evaluated. Twenty-three compounds were identified among which germacrene B (50.66%), germacrene D (22.22%) and (E)-caryophyllene (8.99%) were the main compounds. The highest antiproliferative activity was observed against NCI-ADR/RES (TGI = 31.08 μg/ml) and HT-29 (TGI = 32.81 μg/ml) cell lines. It also showed good antileishmanial activity against Leishmania infantum (IC50 = 30.71 μg/ml). On the other hand, the oil exhibited a small effect against Staphylococcus aureus ATCC 6538, S. aureus ATCC 14458 and Escherichia coli ATCC 10799 (MIC = 250 μg/ml), as well as small antioxidant activity (457 μmol TE/g) assessed through ORACFL assay. These results represent the first report regarding chemical composition and bioactivity of G. australis essential oil. 相似文献
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A new aporphine glycoside, (-)-anolobine-9-O-β-D-glucopyranoside was isolated from the twigs of pawpaw (Asimina triloba) along with 7 known alkaloids including five aporphine alkaloids (anolobine, nornuciferine, norushinsunine, liriodenine, and lysicamine), a proaporhine alkaloid (stepharine), and a tetrahydrobenzylisoquinoline alkaloid (coclaurine). Among these compounds, nornuciferine, lysicamine, stepharine, and coclaurine are reported for the first time from this plant. The structure of the new compound was elucidated by spectroscopic methods, including 1?D, 2?D NMR, and HRESI-MS. The absolute configuration of compounds 1, 2, 7 and 8 was determined by CD experiment. 相似文献
4.
Ana Carolina de C. Correia Tamyris F. Ferreira Italo Rossi R. Martins Cibério L. Macêdo Fabio de S. Monteiro Vicente Carlos O. Costa 《Natural product research》2015,29(10):980-984
Xylopia langsdorfiana A. St.-Hil. &Tul. (Annonaceae) is popularly known in the northeast of Brazil as ‘pimenteira da terra’, and an essential oil (XL-OE) was extracted from its leaves. Since Xylopia species are cited in folk medicine and diterpenes from X. langsdorfiana have spasmolytic activity, this study aimed to investigate a possible spasmolytic action of XL-OE on smooth muscle models. XL-OE (243 and 729 μg/mL) showed low pharmacologic efficacy on guinea pig trachea and rat aorta and uterus. However, in guinea pig ileum, XL-OE (27–729 μg/mL) inhibited carbachol or histamine-induced phasic contractions (1 μM) in a significant and concentration-dependent manner. In addition, XL-OE (81 μg/mL) reduced fluorescence intensity in ileal myocytes stimulated by histamine, indicating a decrease in cytosolic calcium concentration, which could explain the spasmolytic activity. Thus, XL-OE proved to be a promising natural product to be used in gastrointestinal diseases acting by modulating the cytosolic calcium concentration. 相似文献
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A new sesquiterpenoid (?)-ethyl dihydrophaseate (1) was isolated from the stems and leaves of Polyalthia petelotii, together with two clerodane diterpenoids, 16α-hydroxycleroda-3,13(14)Z-dien-15,16-olide (2), 15-hydroxy-cis-ent-cleroda-3,13(E)-diene (3), a eudesmane sesquiterpenoid, eudesm-4(15)-ene-7α,11-diol (4), an aromatic aldehyde, vanillin (5), a bisisoquinolines alkaloid, spinosine (6) and an aporphine alkaloid, (?)-oliveroline-β-N-oxide (7). Their structures were established by extensive spectroscopic analysis, including 2D-NMR techniques. Compounds 3, 4 and 6 were isolated from the genus Polyalthia for the first time and the others obtained originally from P. petelotii. The isolates were assessed for their cytotoxicity against five human tumour lines (HL-60, SMMC-7721, A-549, MCF-7 and SW-480), and the result showed that only 2 displayed weak inhibitory activity. 相似文献
6.
A new N-fatty acyl tryptamine, cheritamine ( 30 ), along with thirty-two compounds including nineteen benzenoids, p-hydroxybenzadehyde ( 1 ), p-hydroxybenzoic acid ( 2 ), methylparabene ( 3 ), 3-chlorobenzoic acid ( 4 ), vanillin ( 5 ), isovanillin ( 6 ), vanillic acid ( 7 ), isovanillic acid ( 8 ), methyl vanillate ( 9 ), methyl isovanillate ( 10 ), syringaldehyde ( 11 ), syringic acid ( 12 ), 3,4,5-trimethoxybenzoic acid ( 13 ), trans-methyl p-coumarate ( 14 ), ferulic acid ( 15 ), p-dihydrocoumaric acid ( 16 ), 3-(4-hydroxy-3,5-dimethoxyphenyl)-1,2-propanediol ( 17 ), 3,4,5 -trimethoxyphenyl-β-D-glucopyranoside ( 18 ) and thalictoside ( 19 ); one p-quinone, 2,6-dimethoxy-p-quinone ( 20 ); one purine, uridine ( 21 ); eight alkaloids, nicotinic acid ( 22 ), thalifoline ( 23 ), doryphornine ( 24 ), (–)-norstephalagine ( 25 ), (-)-romucosine ( 26 ), (+)-pronuciferine ( 27 ), (+)-norisocorydine ( 28 ) and oxoasimilobine (29) and three steroids, β-sitosterol-D-glucoside ( 31 ), stigmasterol-D-glucoside ( 32 ) and 6′-(β-sitosteryl-3-O-β-glucopyranosidyl)hexadecanoate ( 33 ), are isolated from the stems of Annona cherimola. These compounds were characterized and identified by physical and spectral evidence. 相似文献
7.
Two new alkaloids, glaucenamide ( 1 ) and fissiceine ( 2 ), along with fifteen known ones, liriodenine ( 3 ), oxocrebanine ( 4 ), kuafumine ( 5 ), oxoxylopine ( 6 ), atherospermidine ( 7 ), (‐)‐xylopine ( 8 ), (‐)‐N‐acetylxylopine ( 9 ), N‐trans‐feruloyltyramine ( 10 ), aristololactam BII ( 11 ), aristololactam BIII ( 12 ), aristololactam AII ( 13 ), piperolactam A ( 14 ), goniothalactam ( 15 ), norcepharadion B ( 16 ), and noraristolodione ( 17 ) were isolated from the methanolic extracts of the Fissistigma glaucescens. The structures of these compounds were established by means of spectral analysis. 相似文献
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9.
Thi Hoai Nguyen Viet Duc Ho Thi Thao Do Huu Tai Bui Van Kiem Phan Katrin Sak 《Natural product research》2015,29(3):247-252
Chemical investigation of the aerial parts of Uvaria rufa (Dunal) Blume collected from Vietnam yielded one new lignan glycoside, ufaside (1), along with six known compounds, oxoanolobine (2), ergosta-4,6,8(14),22-tetraen-3-one (3), catechin (4), epicatechin (5), daucosterol (6) and glutin-5-en-3-one (7). Their chemical structures were determined by using NMR, HR-MS spectroscopic analyses and in comparison with the reported data. A cytotoxic analysis of U. rufa herb extracts was performed for the first time using nine human cancer cell lines (MCF-7, MDA-MB-231, LNCaP, MKN7, SW480, KB, LU-1, HepG2 and HL-60) derived from different tumour types. Of these seven constituents, compounds 2 and 3 displayed moderate cytotoxicity against the human lung adenocarcinoma cell line (LU-1) with IC50 values of 9.22 ± 1.02 μg/mL and 10.21 ± 1.16 μg/mL, respectively. 相似文献
10.
Elzalina R. Soares Richardson A. de Almeida Bruna R. de Lima Hector H.F. Koolen Caroline C. Lourenço 《Natural product research》2015,29(13):1285-1288
Essential oils from the leaves, twigs and barks of Bocageopsis pleiosperma Maas were obtained by using hydrodistillation and analysed by using gas chromatography coupled to mass spectrometry. Several compounds (51) were detected and identified, being β-bisabolene the main component in all aerial parts of the plant, with higher concentration in the leaves (55.77%), followed by barks (38.53%) and twigs (34.37%). In order to increase the biological knowledge about the essential oil of Bocageopsis species, antimicrobial activities were evaluated against the microorganisms Escherichia coli, Staphylococcus epidermidis, Enterobacter aerogenes, Candida tropicalis, Candida dubliniensis, Candida glabrata and Candida albicans. The essential oil obtained from the barks exhibited a moderate effect against S. epidermidis ATCC 1228 (MIC = 250 μg/mL), while the other oils did not exhibit antimicrobial activity. These results represent the first report about the chemical composition of B. pleiosperma and the first antimicrobial evaluation with a Bocageopsis species. 相似文献