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Yixi Liu Liva Harinantenaina Peggy J. Brodie Carla Slebodnick Martin W. Callmander R. Rakotondrajaona Etienne Rakotobe Vincent E. Rasamison Karen TenDyke Yongchun Shen David G. I. Kingston 《Magnetic resonance in chemistry : MRC》2013,51(9):574-579
Antiproliferative bioassay‐guided fractionation of the ethanol extract of the stems of Anisocycla grandidieri led to the isolation of the known alkaloids stebisimine (1), (+)‐1,2‐dehydrotelobine (2), (+)‐2'‐norcocsuline (3) and puetogaline B (4). Herein, we report the full NMR assignments of all compounds and the X‐ray crystallography of single crystals of compounds 1 and 3. Compounds 2 and 3 showed moderate antiproliferative activity against the A2780 human ovarian cancer cell line with IC50 values of 4.1 ± 0.3 and 2.7 ± 0.3 μM, respectively, and they also displayed selective activity toward the H460 (large cell lung cancer), MCF‐7 (breast ductal carcinoma), and UACC‐257 (melanoma) cell lines. Copyright © 2013 John Wiley & Sons, Ltd. 相似文献
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