排序方式: 共有92条查询结果,搜索用时 15 毫秒
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Ying Dong Bangyu Liu Peng Chen Qun Liu Mang Wang 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2014,126(13):3510-3514
The insertion of an aryne into a C S bond can suppress the addition of an S nucleophile to the aryne in the presence of palladium. Catalyzed by Pd(OAc)2, a wide range of α‐carbamoyl ketene dithioacetals readily react with arynes to selectively afford functionalized 2‐quinolinones in high yields under neutral reaction conditions by a C S activation/aryne insertion/intramolecular coupling sequence. The attractive feature of the new strategy also lies in the versatile transformations of the alkythio‐substituted quinolinone products. 相似文献
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Lin‐Bao Zhang Xin‐Qi Hao Zhan‐Jiang Liu Xin‐Xiang Zheng Shou‐Kun Zhang Jun‐Long Niu Mao‐Ping Song 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2015,127(34):10150-10153
A highly efficient cobalt(II)‐catalyzed alkynylation/annulation of terminal alkynes assisted by an N,O‐bidentate directing group is described. This protocol is characterized by wide substrate scope utilizing cheap cobalt catalysts, and offers a new approach to 3‐methyleneisoindolin‐1‐one, which can be converted into an oxadiazine salt in one step. Moreover, the directing group could be removed in three steps. 相似文献
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Chunlan Song Xin Dong Zhongjie Wang Kun Liu Chien‐Wei Chiang Aiwen Lei 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2019,131(35):12334-12338
The [4+2] annulation represents an elegant and versatile synthetic protocol for the construction of benzene rings. Herein, a strategy for visible‐light induced [4+2] annulation of thiophenes and alkynes, to afford benzene rings, is presented. Under simple and mild reaction conditions, the ready availability and structural diversity of thiophenes and alkynes permit the facile synthesis of several substituted aromatic rings. Valuable drugs and amino acids are also well tolerated. Moreover, DFT calculations explain the high regioselectivity of the reaction. 相似文献
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Prof. Dr. Barry M. Trost Dr. Zhijun Zuo 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(3):1259-1263
A novel Pd0-catalyzed asymmetric [4+3] annulation reaction of two readily accessible starting materials has been developed for building seven-membered heterocyclic architectures. The potential [3+2] side pathway could be suppressed though fine tuning of the conditions. A broad scope of cycloaddition donors and acceptors participated in the transformation with excellent chemo-, regio-, diastereo-, and enantioselectivtities, leading to valuable tetrahydroazepines and benzo[b]oxepines. 相似文献
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《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2017,129(50):16137-16141
α‐Chloroaldehydes have been used as alkyne equivalents in rhodium‐catalyzed syntheses of isoquinolones and 3,4‐dihydroisoquinolins starting from N ‐methoxyamides. Compared to the existing technology, a complementary regioselectivity is achieved. Mechanistic investigations have been performed, and it was found that steric effects of both substrate and additive determine the product selectivity. Various other heterocycles, such as isoquinolines and lactones, can be prepared by transformation of the obtained products. 相似文献
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