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1.
《合成通讯》2013,43(24):4583-4590
Abstract α‐Aminonitriles are prepared upon reaction of aryl carboxaldehydes with LiHMDS and acetone cyanohydrin. This new method provides a general route to the synthesis of various substituted α‐amino‐arylacetonitriles in high yield and purity, and avoids the use of the highly toxic cyanide salts. 相似文献
2.
We describe here a rapid process for the preparation of new 9-chloromethyl-12-aryl-10,12-dihydrobenzo[5,6]chromeno[2,3-d]pyrimidin-11-ones 5a-d and 10-chloromethyl-7-aryl-7,9-dihydrobenzo[7,8]chromeno[2,3-d]pyrimidin-8-ones 6a-d by two different methods utilizing microwave irradiation. This methodology provides better yields(72%–80%) and high purity of the title compounds. 相似文献
3.
Krishna S. Indalkar Chetan K. Khatri Ganesh U. Chaturbhuj 《Tetrahedron letters》2017,58(22):2144-2148
A straightforward, mild, efficient, and environmentally benign protocol for a three-component Strecker reaction of aldehydes or ketones, amines, and trimethylsilyl cyanide catalyzed by sulfated polyborate has been described to afford α-aminonitriles under solvent-free reaction conditions. The major advantages of the present method are excellent yields, shorter reaction time, simple experimental procedure, easy workup procedure, recyclability of the catalyst, solvent-free reaction conditions and ability to tolerate a variety of functional groups which gives economical as well as ecological rewards. 相似文献
4.
PingZHAO YingWuYIN 《中国化学快报》2004,15(9):1043-1046
α-Aminonitriles were prepared efficiently from anodic cyanation of α-amino ester. The effect of different solvents and electrolytes was studied. The other byproducts were analyzed. 相似文献
5.
Winfried Wendelin Wolfgang Kern Ilse Zmölnig Hans-Wolfgang Schramm 《Monatshefte für Chemie / Chemical Monthly》1981,112(8-9):1091-1098
The aminonitriles3a–f react with guanidine inDMF to yield the 5,5-resp. 5-subtituted imidazolidine-2,4-diimines2a–d resp.2f, whereas2e could not be isolated. 7,14-diazadispiro[5.1.5.2]-pentadecan-15-on (7)1, 4-imino-1,3-diazaspiro[4.5]decan-2-one (8a)1 and the 2,4-diaminotriazine (9)1 were isolated as byproducts.1-Aminocyclohexancarbonitrile (3a) reacts with urea to the 4-imino-1,3-diazaspiro[4.5]decan-2-one (8a)1;8a can be prepared from (1-cyancyclohexyl)urea (11a) as well. The structures of the new compounds are proved by NMR-, IR- and mass spectra and the mechanism of the reaction is discussed.
Herrn Prof. Dr.G. Zigeuner zum 60. Geburtstag gewidmet. 相似文献
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N(4-hydroxycyclohexyl)-3-mercapto/cyano-4-arylazetidine-2-one were synthesised from N-(4-hydroxycyclohexyl)-arylaldimine by reacting with ethyl α-mercapto/α-cyanoacetate on basic alumina under microwaves, wherein not only the reaction time has been brought down from hours to minutes in comparison to conventional heating but also with improved yield. 相似文献
8.
《合成通讯》2013,43(7):1207-1214
Abstract A three‐component reaction between aliphatic or aromatic aldehyde, an amine and trimethylsilyl cyanide mediated by solid LiClO4, gave amino nitriles in good to excellent yields. The reaction proceeded smoothly under solvent‐free conditions without any side products. 相似文献
9.
Abhimanyu S. Paraskar 《Tetrahedron letters》2006,47(32):5759-5762
Copper(II) triflate or Et3N have been found to catalyze, under ambient conditions, the addition of a cyanide anion, such as trimethylsilyl cyanide or acetone cyanohydrin, onto in situ generated imines, furnishing α-aminonitriles in excellent yields. 相似文献
10.
The multicomponent Strecker reaction using trimethylsilyl cyanide was accomplished without any type of Lewis acid. The reaction performed in acetonitrile as solvent gave excellent results for any class of aldehydes (aromatic or aliphatic), as well as amines (aromatic or aliphatic). In many cases, α-aminonitrile product was isolated pure after the usual work-up, with quantitative chemical yields. A comparison between different solvents indicated that acetonitrile is the best choice. The rate comparison using different Lewis acids showed that all of them catalyzed the reaction in a similar extent, the difference with the acid Lewis-free being minimal. 相似文献