A new ent-labdane diterpenoid from Andrographis paniculata

<正>A new ent-labdane diterpenoid,19-O-β-D-glucopyranosyl-ent-labda-8(17),13-dien-15,16,19-triol,together with six known ent-labdane diterpenoids,was isolated from the aerial parts of Andrographis paniculaia.The structure of the new compound was elucidated by extensive spectral analysis.     

Constituents of Perltrophe Japonica (Thunb.) Bremk

A naturally occurring derivatives of pyridine, 3,5-pyridinedicarboxamide ( 1 ), lupeol ( 2 ), a steroidal mixture [stigmasterol ( 3a ) and β-sitosterol ( 3b )], steroidal glycosides [stigmasteryl-glucoside ( 4a ) and β-sitosteryl glucoside ( 4b )] and allantoin ( 5 ) were isolated and characterized from the aerial parts of Peritrophe japonica. Their structures were determined by spectral analysis.     

Justiciosides E-G, triterpenoidal glycosides with an unusual skeleton from Justicia betonica

Three new triterpenoidal glucosides, justiciosides E, F and G, were isolated from the aerial portion of Justicia betonica. Their structures were established through chemical and spectroscopic analyses, and showed an unusual A-nor-B-homo oleanan-12-ene skeleton type for the aglycone moiety as A-nor-B-homo-oleanan-10,12-diene-3β,11α,28-triol 28-O-β-d-glucopyranosyl-(1→2)-β-d-glucopyranoside, A-nor-B-homo-oleanan-10,12-diene-3β,11α,28-triol 28-O-β-d-glucopyranosyl-(1→2)-β-d-glucopyranosyl-(1→2)-β-d-glucopyranoside, and 11α-methoxy-A-nor-B-homo-oleanan-10,12-diene-3β,11α,28-triol 28-O-β-d-glucopyranosyl-(1→2)-β-d-glucopyranosyl-(1→2)-β-d-glucopyranoside, respectively.     

Flavone Glycosides from Strobilanthes Formosanus

Two new flavone glycosides, 3′‐hydroxy‐5,7‐dimethoxyflavone 4′‐O‐β‐D‐apiofuranoside ( 1 ), and 5,7‐dimethoxyflavone 4′‐O‐[β‐D‐apiofuranosyl(1→5)‐ β‐D‐glucopyranoside] ( 2 ) along with four known compounds, 4′‐hydroxy‐5,7‐dimethoxyflavone ( 3 ), 2,6‐dimethoxy‐1,4‐benzoquinone ( 4 ), lupeol ( 5 ) and betulin ( 6 ) were isolated from the stem and roots of Strobilanthes formosanus. Their structures were elucidated on the basis of their spectroscopic evidence.     

Owariensisone: a new iridolactone from the whole plant of Brillantaisia owariensis P. Beauv

From the whole plant of Brillantaisia owariensis P. Beauv, a new iridolactone, owariensisone (1) together with six known compounds (nepetin-7-O-glucoside, choline, sucrose, mannitol, xylitol, 1-O-palmitoyl-2-eicosanoyl-3-O-(6-amino-6-deoxy)-β-d-glucopyranosyl-glycerol) were isolated. Structures of these compounds were established by direct interpretation of their spectral data, mainly HR-TOFESIMS, 1-D NMR (¹H and ¹³C) and 2-D NMR (¹H-¹H COSY, HSQC, HMBC, NOESY, TOCSY and DOCSY) and by comparison with the literature.     

Andrographolactone, a unique diterpene from Andrographis paniculata

Andrographolactone (1), possessing an unprecedented diterpene skeleton, was isolated from the EtOAc extract of the aerial parts of Andrographis paniculata. Its structure was established by NMR, IR, UV, and HRESIMS data and subsequently confirmed by X-ray diffraction analysis. A possible biogenetic pathway of 1 was also proposed. Bioassay showed that 1 exhibited cytotoxic activity.