A high‐order element based adaptive mesh refinement strategy for three‐dimensional unstructured grid

Adaptive mesh refinement (AMR) shows attractive properties in automatically refining the flow region of interest, and with AMR, better prediction can be obtained with much less labor work and cost compared to manually remeshing or the global mesh refinement. Cartesian AMR is well established; however, AMR on hybrid unstructured mesh, which is heavily used in the high‐Reynolds number flow simulation, is less matured and existing methods may result in degraded mesh quality, which mostly happens in the boundary layer or near the sharp geometric features. User intervention or additional constraints, such as freezing all boundary layer elements or refining the whole boundary layer, are required to assist the refinement process. In this work, a novel AMR strategy is developed to handle existing difficulties. In the new method, high‐order unstructured elements are first generated based on the baseline mesh; then the refinement is conducted in the parametric space; at last, the mesh suitable for the solver is output. Generating refined elements in the parametric space with high‐order elements is the key of this method and this helps to guarantee both the accuracy and robustness. With the current method, 3‐dimensional hybrid unstructured mesh of huge size and complex geometry can be automatically refined, without user intervention nor additional constraints. With test cases including the 2‐dimensional airfoil and 3‐dimensional full aircraft, the current AMR method proves to be accurate, simple, and robust.     

Prevalence of Antimicrobial Resistant Bacteria from Conjunctival Flora in an Eye Infection Prone Breed (Saint Bernard)

The conjunctival bacterial resident and opportunistic flora of dogs may represent a major source of dissemination of pathogens throughout the environment or to other animals and humans. Nevertheless, contamination with bacteria from external sources is common. In this context, the study of the antimicrobial resistance (AMR) pattern may represent an indicator of multidrug resistant (MDR) strains exchange. The present study was focused on a single predisposed breed—Saint Bernard. The evaluated animals were healthy, but about half had a history of ocular disease/treatment. The swabs collected from conjunctival sacs were evaluated by conventional microbiological cultivation and antimicrobial susceptibility testing (AST). The most prevalent Gram-positive was Staphylococcus spp.; regardless of the history, while Gram-negative was Pseudomonas spp.; exclusively from dogs with a history of ocular disease/treatment. Other identified genera were represented by Bacillus, Streptococcus, Trueperella, Aeromonas and Neisseria. The obtained results suggest a possible association between the presence of mixed flora and a history of ocular disease/treatment. A high AMR was generally observed (90%) in all isolates, especially for kanamycin, doxycycline, chloramphenicol and penicillin. MDR was recorded in Staphylococcus spp. and Pseudomonas spp. This result together with a well-known zoonotic potential may suggest an exchange of these strains within animal human populations and the environment.     

Out-of-plane low field anisotropic magnetoresistance in Nd0.51Sr0.49MnO3 thin films

A comparative study of the out-of-plane anisotropic magnetoresistance (AMR) in single crystalline and polycrystalline thin films of phase separated manganite Nd_0.51Sr_0.49MnO₃ has been carried out. On-axis DC magnetron sputtering was used to deposit the single crystalline films (30 and 100 nm in thickness) on single crystal (0 0 1) LaAlO₃ (LAO) and polycrystalline films (100 nm) on (1 0 0) Yttrium-stabilized ZrO₂ (YSZ) substrates. The in-plane and out-of-plane magnetotransport properties of these films differ significantly. A large low field AMR is observed in all the films. AMR shows a peak below the insulator-metal transition temperature in the single crystalline films, while the same increases monotonically in the polycrystalline film. Relatively larger low field AMR (∼20% at T=78 K and H=1.7 kOe) in the polycrystalline films suggests the dominance of the shape anisotropy.     

室温磁制冷主动式磁蓄冷器数值模拟

提出了一个研究工作参数、设计参数对主动式磁蓄冷器(AMR)制冷性能影响的数值模型。三个主要参数包括:质量流量m、频率f、蓄冷器孔隙率ε,被用来表征AMR的制冷能力。数值模拟的结果表明:对一个AMR而言,存在一个最佳孔隙率;在某一确定孔隙率条件下,AMR存在最佳换热流体质量流量和最佳工作频率;与高频相比,AMR在较低频率下有更好的制冷性能,一味提高频率并不一定能提高AMR的制冷量。模拟结果对磁制冷样机的设计、工作参数的选择有很大的指导意义。     

辐射流体力学的分子动理学自适应加密方法(英文)

通过构造新的平衡分布函数和结合分区自适应网格加密方法,对不带扩散项的平衡辐射流体力学方程,构造二阶的分子动理学BGK-AMR格式.一方面在关心的计算区域中局部加密计算网格,提高计算精度的同时大大节省了计算网格数量和计算时间;另一方面,不同于已有的参数强耦合平衡分布函数,新构造的平衡分布函数中各参数不相互依赖,简化了辐射流体力学分子动理学格式的计算.一维和二维的数值算例显示了格式的性能.     

New Chemotypes for the Inhibition of (p)ppGpp Synthesis in the Quest for New Antimicrobial Compounds

Antimicrobial resistance (AMR) poses a serious threat to our society from both the medical and economic point of view, while the antibiotic discovery pipeline has been dwindling over the last decades. Targeting non-essential bacterial pathways, such as those leading to antibiotic persistence, a bacterial bet-hedging strategy, will lead to new molecular entities displaying low selective pressure, thereby reducing the insurgence of AMR. Here, we describe a way to target (p)ppGpp (guanosine tetra- or penta-phosphate) signaling, a non-essential pathway involved in the formation of persisters, with a structure-based approach. A superfamily of enzymes called RSH (RelA/SpoT Homolog) regulates the intracellular levels of this alarmone. We virtually screened several fragment libraries against the (p)ppGpp synthetase domain of our RSH chosen model Rel_Seq, selected three main chemotypes, and measured their interaction with Rel_Seq by thermal shift assay and STD-NMR. Most of the tested fragments are selective for the synthetase domain, allowing us to select the aminobenzoic acid scaffold as a hit for lead development.     

Accurate and robust adaptive mesh refinement for aerodynamic simulation with multi‐block structured curvilinear mesh

A multi‐block curvilinear mesh‐based adaptive mesh refinement (AMR) method is developed to satisfy the competing objectives of improving accuracy and reducing cost. Body‐fitted curvilinear mesh‐based AMR is used to capture flow details of various length scales. A series of efforts are made to guarantee the accuracy and robustness of the AMR system. A physics‐based refinement function is proposed, which is proved to be able to detect both shock wave and vortical flow. The curvilinear mesh is refined with cubic interpolation, which guarantees the aspect ratio and smoothness. Furthermore, to enable its application in complex configurations, a sub‐block‐based refinement strategy is developed to avoid generating invalid mesh, which is the consequence of non‐smooth mesh lines or singular geometry features. A newfound problem of smaller wall distance, which negatively affects the stability and is never reported in the literature, is also discussed in detail, and an improved strategy is proposed. Together with the high‐accuracy numerical scheme, a multi‐block curvilinear mesh‐based AMR system is developed. With a series of test cases, the current method is verified to be accurate and robust and be able to automatically capture the flow details at great cost saving compared with the global refinement. Copyright © 2015 John Wiley & Sons, Ltd.     

The role of thermal instability in star formation

The observations tell us that the density in the giant molecularclouds in which stars are formed is inhomogeneous on a varietyof scales, but it seems unlikely that this is due to the actionof gravitational instability. This paper describes numericalcalculations using an adaptive mesh refinement magnetohydrodynamicscode that show that thermal instability may have an importantrole to play in the formation of this structure     

自旋阀中的各向异性磁电阻效应

采用平面霍尔效应测量方法，对Ta(8nm)/NiFe(7nm)/Cu(24nm)/NiFe(44nm)/FeMn(14nm)/Ta(6nm)自旋阀多层膜进行了研究.结果表明，在样品中存在着自由层和被钉扎层之间的各向异性磁电阻的“混合”效应.与通常所采用的磁电阻测量方法相结合，平面霍尔效应的测 量可以给出自旋阀中各向异性磁电阻以及自由层和被钉扎层的磁矩随外场变化的更多信息. 关键词： 自旋阀 各向异性磁电阻 平面霍尔效应     

A study of detonation diffraction and failure for a model of compressible two-phase reactive flow

A two-phase model of heterogeneous explosives, with a reaction rate that is proportional to the gas-phase pressure excess above an ignition threshold, is examined computationally. The numerical approach, a variant of Godunov's method designed to accommodate nonconservative terms in the hyperbolic model, extends previous work of the authors to two-dimensional configurations. The focus is on the behavior of an established detonation as it rounds a 90° corner and undergoes diffraction. The dependence of the post-diffraction conduct on the reaction rate is explored by varying the reaction-rate prefactor and the ignition threshold. The aim is to determine whether the model, as postulated, can capture dead zones, which are pockets of unreacted or partially reacted explosive observed in the vicinity of the corner in diffraction experiments. Results of this study are compared with those of a similar investigation on the one-phase ignition-and-growth model.