血小板阻聚药物中间体N-环己基-5-氯丁基-1H-四氮唑的合成

以δ-戊内酯和环己胺为原料合成了抗血小板聚集药物西洛他唑的重要中间体N-环己基-5-氯丁基-1H-四氮唑，选择了合适的相转移催化剂及安全的叠氮试剂并获得较高的收率。     

1，4二环己基取代六元瓜环与Na(Ⅰ)自组装实体的合成与晶体结构

A novel complex of a new 1,4-dicyclohexyl cucurbituril(DCYQ[6]) with sodium(Ⅰ) ion was synthesized, and the crystal structure was determined by X-ray diffraction technique. In this self-assembled entity both the cavity interaction of DCYQ[6] included a nitrate anion and the portal interaction of the dipole carbonyls of DCYQ[6] with sodium cations lead to form self assembled molecular capsules. The crystal structure of the entity shows a packing of the self assembled molecular capsules connected by hydrogen bonds of water molecules. CCDC: 271400.     

相变温度低且宽的含有胆甾烯基和反式-4-烷基环己基苯氧基的二介晶化合物

Unsymmetrical dimesogenic compounds with cholesteryl and 4-（trans-4-n-alkylcyclohexyl）phenoxy parts were synthesized by condensation of cholester-3-yl 6-bromohexanoate with appropriate 4-（trans-4-n-alkylcyclohexyl）- phenols. Structures and thermal phase behaviour of these dimesogenic compounds have been confirmed by IR, IH NMR, elemental analysis, DSC, polarity microscopy and XRD measurements. Their thermal phase behaviour was significantly different with that of other cholesterol-based dimesogens while they exhibited low and wide phase transition temperature.     

肝素化聚甲基硅氧烷-聚氧乙烯接枝物的合成及其体外抗凝血性能评价

以二甲基硅油接枝端羟基聚氧乙烯（ＰＤＭＳ ｇ ＰＥＯ ＯＨ）为基材，用二环己基碳二亚胺（ＤＣＣＩ）作脱剂，研究了羟基（ＯＨ）与肝素上的羧基（—ＣＯＯＨ）之间的脱水缩合反应，制备出肝素化的抗血栓材料ＰＤＭＳ ｇ ＰＥＯ Ｈｅｐ，并对其涂覆表面的肝素含量和体外抗凝血性能进行了初步评价．实验结果表明，肝素接枝的共聚物具有优良的抗凝血性能和一定的应用前景．     

Synthesis and Crystal Structure of Mo(CO)_4(NNP) (NNP=2-(N-Cyclohexyl-N-diphenylphosphinomethyl)aminopyridine)

1 INTRODUCTION The pyridyl-phosphine ligands have been widely used for many years to synthesize hetero- or homo-nuclear metal complexes[1], as electronic differentiation associated with the hard (N) and soft (P) donor atoms dictates their unique reactivities and coordination modes. One of the most common pyridylphosphines studied to date is (2-C5H4N)PPh2 which displays numerous ligating modes ranging from P-coordination and P,N-chelation to the more common P,N-bridging of two metal …     

4-戊基(4′-丙基环己基)三联苯液晶的合成

在相转移催化剂十六烷基三甲基溴化铵的助催化作用下,用PdCl2催化芳基硼酸与溴代芳烃偶联反应合成了液晶化合物4－戊基（4′－丙基环己基）三联苯,反应转化率达到93％,反式产物选择性86％。结构经IR,^1H NMR和MS确证,并用DSC测定了此液晶的相变数据。考察了加料顺序和相转移催化剂对偶联反应的影响。提出了相转移条件下可能的催化循环机理,认为芳基硼酸是以ArB(OH)3^-离子形式参与偶联反应的。     

分光光度法测定水溶液中的有机酸含量

利用水溶液中的有机酸在高氯酸羟胺(HAP)和N,N′-二环己基碳酰亚胺(DCC)存在的条件下生成的羟肟酸,以及羟肟酸在酸性高氯酸铁溶液中显色的性质,建立了一种分光光度测定水中有机酸含量的方法。对显色剂的酸度、浓度、加入体积、HAP和DCC的浓度、加入体积以及显色反应的温度、反应时间对吸光度的影响进行了考察。结果表明,该显色反应在反应条件:0.0687mol/LHAP1.0mL、0.6mol/LDCC0.5mL、震荡均匀后室温下放置反应15min、0.02mol/L酸性高氯酸铁溶液(高氯酸浓度0.3mol/L)显色条件下具有最大的吸光度;并对正丁酸、正戊酸、苯甲酸进行了线性关系考察。结果表明,该检测方法具有仪器简单、操作方便、线性范围较宽、准确度高等优点,可用于那些不易从水溶液中萃取的有机酸的测定,也可用于液相色谱洗脱液中有机酸的测定。     

α-萘基环己基甲基酮仿生合成新方法

α-萘基环己基甲基酮仿生合成新方法;四氢叶酸辅酶;苯并咪唑甲基碘盐;Grignard试剂;α-萘基环己基甲基酮;仿生合成     

1,2-二芳基乙炔的简便合成及其结构与性能关系研究

1,2-Diarylacetylenes have been synthesized by a facile method consisting of an addition of diaryl ketone with acetyl chloride and the elimination of resultant ethene chloride. Correlation between physical properties and structure of the 1,2-diarylacetylene has been studied by differential scanning calorimeter （DSC）, refractor and electro-optical parameter test instrument. The results show that birefringence was increased with inserting cyclohexyl into the skeleton, but mesophase range, melting and clearing points were reduced with introducing the ethylene bridge in the molecule, and birefringence, viscosity, clearing point and mesophase range could all be decreased with perfluoro alkyl/alkoxyl terminal instead of alkyl/alkoxyl moiety.     

双相(O/W)识别手性萃取分离α-环己基扁桃酸对映体

提出一种新的手性分离技术双相(O/W)识别手性萃取. 研究了α-环己基扁桃酸对映体在D(L)-酒石酸异丁酯1,2-二氯乙烷有机相和β-环糊精衍生物水相萃取体系中的分配行为; 考察了β-环糊精衍生物种类和浓度、酒石酸酯构型和浓度、水相pH 值等因素对萃取性能的影响. 实验结果表明, 双相(O/W)识别手性萃取具有很强的手性分离能力, 羟丙基β-环糊精、羟乙基β-环糊精、甲基β-环糊精均对S-α-环己基扁桃酸对映体的识别能力大于对R-α-环己基扁桃酸对映体的识别能力, 其中以羟丙基β-环糊精的识别能力最强; 而D-酒石酸异丁酯的识别能力刚好相反; 在羟丙基β-环糊精和D-酒石酸异丁酯萃取体系中, α-环己基扁桃酸外消旋体一次萃取分离后, 水相中S-对映体e.e.%达到27.6%, R-和S-对映体的分配系数(k_R和k_S)分别为2.44和0.98, 分离因子(α)达2.49; 同时pH值和萃取剂浓度对手性分离能力有显著影响. 双相(O/W)识别手性萃取对外消旋体化合物的制备性分离有着十分重要的意义.