血管内皮生长因子结合可降解壳聚糖治疗大鼠心肌梗塞的研究

摘要:目的 研 究 血 管 内 皮 生 长 因 子 ( vascular endothelial growth factor, VEGF ) 结 合 可 降 解 壳 聚 糖 ( degradablechitosan,DC)对心肌梗塞大鼠的治疗作用。 方法 将 32 只 SD 大鼠随机分为假手术组、模型组、VEGF 组和 VEGF+ DC 组,每组 8 只。 4 组大鼠均采用结扎冠状动脉左前降支的方法进行造模,其中假手术组只穿线不结扎。 造模后, 向模型组大鼠心肌注射 100 μL 生理盐水,VEGF 组大鼠于同一位置注射同体积 VEGF 溶液,VEGF+DC 组大鼠注射 VEGF+DC 溶液。 造模 4 周 后,对 所 有 实 验 大 鼠 进 行 超 声 心 功 能 检 测,考 察 左 心 室 收 缩 期 及 舒 张 期 前 壁 厚 度( LVAW;s 和 LVAW;d) 、左心室收缩期及舒张期内径( LVID;s 和 LVID;d) 、左心室收缩期及舒张期容积( LV Vol;s 和 LV Vol;d) 、左室射血分数( EF% )及短轴缩短率( FS% ) ,血流动力学考察左室舒张末压( EDP ) 和等容收缩期及 舒张期左心室内压力上升最大速率( + dp / dt 和 - dp / dt) ,计算左心室指数( LVM / BW) 并对心肌进行苏木素-伊红 ( HE)染色观察各组实验大鼠心肌病理变化。 结果 VEGF 组和 VEGF+DC 组大鼠的心肌梗塞均得到有效改善,其 中 VEGF+DC 组的改善作用更加显著。 结论 VEGF 结合 DC 对心肌梗塞大鼠的心功能具有改善作用,具有一定的治疗作用。     

Preparation and Properties of Sr3B2O6:Dy3+, Eu3+ White Phosphors Using the High-Temperature Solid-State Method

Journal of Applied Spectroscopy - Sr3B2O6:Dy3+, Eu3+ single-matrix white-light-emitting materials are prepared using the high-temperature solid-state method. The microstructure, emission spectrum,...     

2017—2019 年北京地区实验动物质量抽检结果分析

摘要:目的 比对分析 2017—2019 年北京地区实验动物微生物及遗传质量监测结果,为实验动物产业发展提供参考。 方法 按照国家和地方现行实验动物检测标准,对北京地区实验动物生产单位进行抽检,并发布检测报告。按照报告数据,对此阶段小鼠、大鼠、豚鼠、地鼠、兔、犬、猴和小型猪共 8 个品种的实验动物按照品种、等级、单位等进行分类,分析质量问题,并与 2014—2016 年同期实验动物质量比对,分析变化趋势。 结果 2017—2019 年分别抽检动物 144、131 和 135 批次,检出不合格批次分别为 30、15 和 17 批。 不合格主要因素为兔、犬及猪免疫不达标(20 批) ,病原感染 20 批,未发现遗传变异。 与 2014—2016 年同期相比,未检出遗传问题相同,免疫不达标状况好转,但病原感染出现上升。 结论 通过质量分析比对,能够为实验动物产业健康发展提供数据支持。     

Exact solutions of an asymmetric double well potential

Journal of Mathematical Chemistry - The analytical solutions of an asymmetric double well potential $$V(x)=a\, x^2-b\, x^3+c\, x^4$$ are found to be a triconfluent Heun function $$H_{T}(\alpha ,...     

Anti-Markovnikov Hydroamination of Racemic Allylic Alcohols to Access Chiral γ-Amino Alcohols

A ruthenium-catalyzed formal anti-Markovnikov hydroamination of allylic alcohols for the synthesis of chiral γ-amino alcohols is presented. Proceeding via an asymmetric hydrogen-borrowing process, the catalysis allows racemic secondary allylic alcohols to react with various amines, affording enantiomerically enriched chiral γ-amino alcohols with broad substrate scope and excellent enantioselectivities (68 examples, up to >99 % ee).     

Nanocomposite hydrogel consisting of Na‐montmorillonite with enhanced mechanical properties

A new kind of nanocomposite (NC) hydrogel with Na‐montmorillonite (MMT) is presented in this article. The NC hydrogels were synthesized by free radical copolymerization of acrylamide and (3‐acrylamidopropyl) trimethylammonium chloride (ATC) in the presence of MMT and N,N′‐methylene‐bis‐acrylamide used as chemical cross‐linker. Due to the cation‐exchange reaction between MMT and ATC (cationic monomer) during the synthesis of NC hydrogels, MMT platelets were considered chemical “plane” cross‐linkers, different from “point” cross‐linkers. With increasing amount of MMT, the crosslinking degree enhanced, causing a decrease of the swelling degree at equilibrium. Investigations of mechanical properties indicated that NC hydrogels exhibited enhanced strength and toughness, which resulted from chemical interaction between exfoliated MMT platelets and polymer chains in hydrogels. Dynamic shear measurements showed that both storage modulus and loss modulus increased with increasing MMT content. The idea described here provided a new route to prepare hydrogels with high mechanical properties by using alternative natural Na‐MMT. © 2015 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2015 , 53, 1020–1026     

2种煤液化残渣氧化萃余物中杂原子化合物的鉴定

在40℃恒温水浴下用次氯酸钠对2种煤液化残渣进行氧化,将反应所得混合物用滤膜过滤,滤出液依次用石油醚、二硫化碳、四氯化碳和乙酸乙酯萃取,得到的萃取物用气相色谱/质谱(GC/MS)分析.根据分析结果系统地考察了2种煤液化残渣中所含杂原子化合物的分布,为从煤液化残渣中选择性地脱除这些杂原子化合物及提取高附加值化学品提供了一条路径.     

Formation of Azulene-Embedded Nanographene: Naphthalene to Azulene Rearrangement During the Scholl Reaction

Incorporation of a non-hexagonal ring into a nanographene framework can lead to new electronic properties. During the attempted synthesis of naphthalene-bridged double [6]helicene and heptagon-containing nanographene by the Scholl reaction, an unexpected azulene-embedded nanographene and its triflyloxylated product were obtained, as confirmed by X-ray crystallographic analysis and 2D NMR spectroscopy. A 5/7/7/5 ring-fused substructure containing two formal azulene units is formed, but only one of them shows an azulene-like electronic structure. The formation of this unique structure is explained by arenium ion mediated 1,2-phenyl migration and a naphthalene to azulene rearrangement reaction according to an in-silico study. This report represents the first experimental example of the thermodynamically unfavorable naphthalene to azulene rearrangement and may lead to new azulene-based molecular materials.