Hitherto-Unexplored Photodynamic Therapy of Ag2S and Enhanced Regulation Based on Polydopamine In Vitro and Vivo

Given their superior penetration depths, photosensitizers with longer absorption wavelengths present broader application prospects in photodynamic therapy (PDT). Herein, Ag₂S quantum dots were discovered, for the first time, to be capable of killing tumor cells through the photodynamic route by near-infrared light irradiation, which means relatively less excitation of the probe compared with traditional photosensitizers absorbing short wavelengths. On modification with polydopamine (PDA), PDA-Ag₂S was obtained, which showed outstanding capacity for inducing reactive oxygen species (increased by 1.69 times). With the addition of PDA, Ag₂S had more opportunities to react with surrounding O₂, which was demonstrated by typical triplet electron spin resonance (ESR) analysis. Furthermore, the PDT effects of Ag₂S and PDA-Ag₂S achieved at longer wavelengths were almost identical to the effects produced at 660 nm, which was proved by studies in vitro. PDA-Ag₂S showed distinctly better therapeutic effects than Ag₂S in experiments in vivo, which further validated the enhanced regulatory effect of PDA. Altogether, a new photosensitizer with longer absorption wavelength was developed by using the hitherto-unexplored photodynamic function of Ag₂S quantum dots, which extended and enhanced the regulatory effect originating from PDA.     

论《熊出没》中的动画角色设计

动画片《熊出没》不仅获得了极高的收视率，还获得了“金猴奖”中动画系列片金奖和动画形象金奖两个重量级奖项。该动画片成功的关键在于动画角色的塑造，通过三个主要角色：聪明的熊大、好吃懒做的熊二及顶着大光头的伐木工人，角色设定相对单调，但仍然受到大众的喜爱，原因就在于“创意”独特，符合受众的感知能力，满足了受众群体的视觉需求。在形象塑造上通过故事情节现代化的演绎、夸张动作安排、独特的地方口音和流行化语言风格等富有人性化的艺术表现形式，刻画了三个角色的性格，符合读者的审美期待，实现了虚拟动画和真实受众之间的沟通。     

Characteristics of black carbon aerosol in Jiaxing,China during autumn 2013

We conducted measurements of black carbon（BC） aerosol in Jiaxing,China during autumn from September 26 to November 30,2013.We investigated temporal and diurnal variations of BC,and its correlations with meteorological parameters and other major pollutants.Results showed that hourly mass concentrations of BC ranged from 0.2 to 22.0 μg/m³,with an average of 5.1 μg/m³.The diurnai variation of BC exhibited a bimodal distribution,with peaks at 07:00 and 18:00.The morning peak was larger than the evening peak.The mass percentages of BC in PM_2.5 and PM₁₀ were 7.1%and 4.8%,respectively.The absorption coefficient of BC was calculated to be 44.4 Mm^-1,which accounted for 11.1%of the total aerosol extinction.BC was mainly emitted from local sources in southwestern Jiaxing where BC concentrations were generally greater than 11 μg/m³ during the measurement period.Correlation analysis indicated that the main sources of BC were motor vehicle exhaust,and domestic and industrial combustion.     

Mass and isotopic concentrations of water-insoluble refractory carbon in total suspended particulates at Mt.Waliguan Observatory(China)

Mass concentration and isotopic values δ¹³C and ¹⁴C are presented for the water-insoluble refractory carbon（WIRC） component of total suspended particulates（TSP）,collected weekly during 2003,as well as from October 2005 to May 2006 at the WMO-GAW Mt.Waliguan（WLG） site.The overall average WIRC mass concentration was（1183±120）ng/m³（n = 79）,while seasonal averages were 2081 ±1707（spring）,454±205（summer）,650±411（autumn）,and 1019±703（winter） ng/m3.Seasonal variations in WIRC mass concentrations were consistent with black carbon measurements from an aethalometer,although WIRC concentrations were typically higher,especially in winter and spring.The δ¹³C PDB value（-25.3 ± 0.8）%.determined for WIRC suggests that its sources are C₃ biomass or fossil fuel combustion.No seasonal change in δ¹³C PDB was evident.The average percent Modern Carbon（pMC） for ¹⁴C in WIRC for winter and spring was（67.2 ± 7.7）%（n = 29）.Lower pMC values were associated with air masses transported from the area east of WLG,while higher pMC values were associated with air masses from the Tibetan Plateau,southwest of WLG.Elevated pMC values with abnormally high mass concentrations of TSP and WIRC were measured during a dust storm event.     

煤直接液化油中混合酚的分离研究

利用分子筛择形特点，对煤直接液化油中的混合酚实施高效分离。本研究选取间甲酚和对甲酚作为分离煤直接液化油馏分段混合酚的模型化合物，采用化学液相沉积法对HZSM-5吸附剂的孔口结构进行改变，分析分子筛硅铝比及颗粒粒径对模型化合物间甲酚和对甲酚吸附分离性能的影响，以获得高性能固相吸附剂，并将其应用于180-190℃馏分段混合酚分离。结果表明，当分子筛硅铝比为25、粒径为3-5 μm时，分子筛的孔口结构调节效果最优；当正硅酸乙酯的最小用量为0.2 mL/g时，固相吸附剂的吸附量为0.03 g/g，对甲酚选择性高于95%。由于外表面沉积物对吸附剂的孔口结构变化，导致对甲酚选择性的提高。进一步采用HZSM-5（1）吸附剂对真实煤直接液化油混合酚的分离中发现，苯酚和对甲酚的选择性均达到100%。     

市级党校图书馆功能转变研究

为了更好应对信息技术发展带来的挑战，市级党校图书馆应明确功能定位，确定图书馆功能转变的路径方式，客观分析影响图书馆功能转变的不利因素，制定具体措施，实现市级党校图书馆的功能转变。     

论高校图书馆学科馆员个人素质和业务能力的提升

学科馆员是图书馆馆藏资源的重要载体,也是图书馆提供读者服务的关键。阐述了学科馆员的定义与内涵,介绍了学科馆员的工作内容,探讨了学科馆员个人素质和业务能力的提升空间。     

碳钢膏剂无孔渗硅工艺的研究

本研究用膏剂法进行无孔渗硅研究,透射电镜、电子探针和M351腐蚀仪分析证实:获得了致密、无孔隙、具有良好耐磨性和耐腐蚀性的渗硅层,并分析了渗硅层形成机理及表层疏松层以及内部孔隙成因。     

导航系统视觉快速跟踪方法

提出了一种图象搜索的方法 ,适用于变化的环境 ,通过灰度值偏移校正二维阈值化和噪声滤波的方法能有效排除由于光源所引起的各种干扰 .本方法处理速度快 ,满足自引导车实时跟踪和导航的需要