Hitherto-Unexplored Photodynamic Therapy of Ag2S and Enhanced Regulation Based on Polydopamine In Vitro and Vivo

Given their superior penetration depths, photosensitizers with longer absorption wavelengths present broader application prospects in photodynamic therapy (PDT). Herein, Ag₂S quantum dots were discovered, for the first time, to be capable of killing tumor cells through the photodynamic route by near-infrared light irradiation, which means relatively less excitation of the probe compared with traditional photosensitizers absorbing short wavelengths. On modification with polydopamine (PDA), PDA-Ag₂S was obtained, which showed outstanding capacity for inducing reactive oxygen species (increased by 1.69 times). With the addition of PDA, Ag₂S had more opportunities to react with surrounding O₂, which was demonstrated by typical triplet electron spin resonance (ESR) analysis. Furthermore, the PDT effects of Ag₂S and PDA-Ag₂S achieved at longer wavelengths were almost identical to the effects produced at 660 nm, which was proved by studies in vitro. PDA-Ag₂S showed distinctly better therapeutic effects than Ag₂S in experiments in vivo, which further validated the enhanced regulatory effect of PDA. Altogether, a new photosensitizer with longer absorption wavelength was developed by using the hitherto-unexplored photodynamic function of Ag₂S quantum dots, which extended and enhanced the regulatory effect originating from PDA.     

工程造价专业教学改革探讨——以新余学院为例

提出了工程造价专业建设目标,对工程造价专业人才培养模式、教学计划、教学手段和课程考核等方面的改革进行全面阐述,结合当前工程造价专业改革的现状,提出了具有较强实用性和可行性的工程造价专业教学改革方案。     

AR-Grams:一种应用于网络舆情热点发现的文本聚类方法

网络舆情热点发现是一种常用且处理速度要求较高的应用.针对网络舆情热点发现这一特殊应用场合,本文提出了一种基于随机N-Gram的文本聚类方法AR-Grams.该方法通过随机N-Gram的文本相似度计算方法,确立待聚类文档集中各个初始聚类的标志文档并完成初步的聚类操作,继而通过聚类元素数阈值来确定初始聚类,并可根据实际情况确定是否执行聚类合并.该方法生成的聚类内聚性好,准确率高.另外,为了便于评估整体的聚类效果,提出了聚类的整体覆盖率和正确覆盖率.实验结果表明:与对比方法DR-Grams相比,在低阈值时,AR-Grams的准确率、召回率、F-score、正确覆盖率分别提高了11.9％、9.1％、10.2％和9.2％,提升效果尤为明显;在高阈值时,效果基本相当;在整体上,前述4项指标则分别提高了4.5％、2.9％、3.5％和3.0％,优于对比方法DR-Grams.     

Investigations in the recrystallization of evolved gases from pyrolysis process of melamine

Journal of Thermal Analysis and Calorimetry - A complete analysis of the thermal process about melamine was presented, in which different methods were applied to determine the characteristic of the...     

基于社会资本视角的图书馆知识营销研究

社会资本对图书馆知识营销具有提供交易场域和情感支持、降低交易费用、提高抗风险能力、减少信息不对称等作用,但网络状况、信任程度、个体调用能力、社会结构稳定程度、意识形态类型、规范与惩罚程度等因素对资本积累具有重大的影响.从社会资本视角,探讨了社会资本理论在图书馆知识营销中的应用,并提出了应对各个影响因素的策略.     

火焰原子发射光谱法测定电解质饮料中钾钠的含量

建立了火焰原子发射光谱法测定电解质饮料中钾和钠含量的方法.钾、钠的方法检出限分别为0.004 22μg/m L和0.002 16μg/m L,钾、钠的加标回收率分别为91.1%~100.9%和93.0%~102.8%.该方法操作简单、快速、准确度高、重现性好、无需使用附加光源,测定结果与火焰原子吸收光谱法无显著性差异.     

Utilizing the Space‐Charge Region of the FeNi‐LDH/CoP p‐n Junction to Promote Performance in Oxygen Evolution Electrocatalysis

The modulation of electron density is an effective option for efficient alternative electrocatalysts. Here, p‐n junctions are constructed in 3D free‐standing FeNi‐LDH/CoP/carbon cloth (CC) electrode (LDH=layered double hydroxide). The positively charged FeNi‐LDH in the space‐charge region can significantly boost oxygen evolution reaction. Therefore, the j at 1.485 V (vs. RHE) of FeNi‐LDH/CoP/CC achieves ca. 10‐fold and ca. 100‐fold increases compared to those of FeNi‐LDH/CC and CoP/CC, respectively. Density functional theory calculation reveals OH^? has a stronger trend to adsorb on the surface of FeNi‐LDH side in the p‐n junction compared to individual FeNi‐LDH further verifying the synergistic effect in the p‐n junction. Additionally, it represents excellent activity toward water splitting. The utilization of heterojunctions would open up an entirely new possibility to purposefully regulate the electronic structure of active sites and promote their catalytic activities.     

Planar AIEgens with Enhanced Solid-State Luminescence and ROS Generation for Multidrug-Resistant Bacteria Treatment

Planar luminogens have encountered difficulties in overcoming intrinsic aggregation-caused emission quenching by intermolecular π-π stacking interactions. Although excited-state double-bond reorganization (ESDBR) can guide us on designing planar aggregation-induced emission (AIE) luminogens (AIEgens), its mechanism has yet been elucidated. Major challenges in the field include methods to efficiently restrict ESDBR and enhance AIE performance without using bulky substituents (e.g., tetraphenylethylene and triphenylamine). In this study, we rationally developed fluoro-substituent AIEgens with stronger intermolecular H-bonding interaction for restricted molecular motions and increased crystal density, leading to decreased nonradiative decay rate by one order of magnitude. The adjusted ESDBR properties also show a corresponding response to variation in viscosity. Furthermore, their aggregation-induced reactive oxygen species (ROS) generations have been discovered. The application of such planar AIEgen in treating multidrug-resistant bacteria has been demonstrated in a mouse model. The relationship between ROS generation and distinct E/Z-configurational stacking behaviors have been further understood, providing a design principle for synthesizing planar AIEgen-based photosensitizers.     

“零被引专利”就没有价值吗?——“零被引专利”在科学论文中的应用分析

 分析前人对零被引的研究成果发现，"零被引"的定义可能存在一定的局限，即只考察同类数据库中的引用情况。分析CSTPCD 2009-2012年的科技论文与引文发现，期刊论文引用了大量的技术专利。存在专利数据库中的"零被引专利"在科技论文中却有较高的引用次数。以其中1件"零被引专利"CN 01134280.3为例，从技术内容解读、10篇施引文献及其内容分析，展示了该项技术发明影响的研究主题，并通过文献调研解析了该项研究成果的工业化应用。基于钱学森的"基础科学-技术科学-工程科学"理论，探讨了使用较高科技论文引用次数的"零被引专利"及较高专利引用次数的"零被引论文"定量分析技术科学的可能性。     

The visible and ultraviolet organic light-emitting diodes with germanium dioxide as facile solution-processed anode buffer layer

Germanium dioxide (GeO₂) aqueous solutions are facilely prepared and the corresponding anode buffer layers (ABLs) with solution process are demonstrated. Atomic force microscopy, X-ray photoelectron spectroscopy and ultraviolet photoelectron spectroscopy measurements show that solution-processed GeO₂ behaves superior film morphology and enhanced work function. Using GeO₂ as ABL of organic light-emitting diodes (OLEDs), the visible device with tris(8-hydroxy-quinolinato)aluminium as emitter gives maximum luminous efficiency of 6.5 cd/A and power efficiency of 3.5 lm/W, the ultraviolet device with 3-(4-biphenyl)-4-phenyl-5-tert-butylphenyl-1,2,4-triazole as emitter exhibits short-wavelength emission with peak of 376 nm, full-width at half-maximum of 42 nm, maximum radiance of 3.36 mW/cm² and external quantum efficiency of 1.5%. The performances are almost comparable to the counterparts with poly (3,4-ethylenedioxythiophene):poly (styrenesulfonate) as ABL. The current, impedance, phase and capacitance as a function of voltage characteristics elucidate that the GeO₂ ABL formed from appropriate concentration of GeO₂ aqueous solution favors hole injection enhancement and accordingly promoting device performance.