Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

Blood pressure is a heritable trait influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (≥140?mm?Hg systolic blood pressure or ≥90?mm?Hg diastolic blood pressure). Even small increments in blood pressure are associated with an increased risk of cardiovascular events. This genome-wide association study of systolic and diastolic blood pressure, which used a multi-stage design in 200,000 individuals of European descent, identified sixteen novel loci: six of these loci contain genes previously known or suspected to regulate blood pressure (GUCY1A3-GUCY1B3, NPR3-C5orf23, ADM, FURIN-FES, GOSR2, GNAS-EDN3); the other ten provide new clues to blood pressure physiology. A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function. We also observed associations with blood pressure in East Asian, South Asian and African ancestry individuals. Our findings provide new insights into the genetics and biology of blood pressure, and suggest potential novel therapeutic pathways for cardiovascular disease prevention.     

Random quantum magnets with broad disorder distribution

We study the critical behavior of Ising quantum magnets with broadly distributed random couplings (J), such that P(ln J) ∼ | ln J|^{-1 - α}, α > 1, for large | ln J| (Lévy flight statistics). For sufficiently broad distributions, α < , the critical behavior is controlled by a line of fixed points, where the critical exponents vary with the Lévy index, α. In one dimension, with = 2, we obtained several exact results through a mapping to surviving Riemann walks. In two dimensions the varying critical exponents have been calculated by a numerical implementation of the Ma-Dasgupta-Hu renormalization group method leading to ≈ 4.5. Thus in the region 2 < α < , where the central limit theorem holds for | ln J| the broadness of the distribution is relevant for the 2d quantum Ising model. Received 6 December 2000 and Received in final form 22 January 2001     

Interfacial Adsorption in Two-Dimensional Potts Models

The interfacial adsorption W at the first-order transition in two-dimensional q-state Potts models is studied. In particular, findings of Monte Carlo simulations and of density-matrix renormalization group calculations at q=16 are consistent with the analytic result, obtained in the Hamiltonian limit at large values of q, that Wt ^–1/3 on approach to the bulk critical temperature T _c, t=|T _c–T|/T _c. In addition, the numerical findings allow to estimate corrections to scaling. Our study supports and quantifies a previous conclusion by Bricmont and Lebowitz based on low temperature expansions.     

On the critical temperature of non-periodic Ising models on hexagonal lattices

The critical temperature of layered Ising models on triangular and honeycomb lattices are calculated in simple, explicit form for arbitrary distribution of the couplings.     

Random and aperiodic quantum spin chains: A comparative study

According to the Harris-Luck criterion the relevance of a fluctuating interaction at the critical point is connected to the value of the fluctuation exponent . Here we consider different types of relevant fluctuations in the quantum Ising chain and investigate the universality class of random as well as deterministic-aperiodic models. At the critical point the random and aperiodic systems behave similarly, due to the same type of extreme broad distribution of the energy scales at low energies. The critical exponents of some averaged quantities are found to be a universal function of , but some others do depend on other parameters of the distribution of the couplings. In the off-critical region there is an important difference between the two systems: there are no Griffiths singularities in aperiodic models. Received: 18 November 1997 / Received in final form: 24 November 1997 / Accepted: 8 January 1997     

Long-range correlations in the nonequilibrium quantum relaxation of a spin chain

We consider the nonstationary quantum relaxation of the Ising spin chain in a transverse field of strength h. Starting from a homogeneously magnetized initial state the system approaches a stationary state by a process possessing quasi-long-range correlations in time and space, independent of the value of h. In particular, the system exhibits aging (or lack of time-translational invariance on intermediate time scales) although no indications of coarsening are present.