全文获取类型
收费全文 | 19490篇 |
免费 | 2362篇 |
国内免费 | 2247篇 |
专业分类
化学 | 7558篇 |
晶体学 | 195篇 |
力学 | 742篇 |
综合类 | 215篇 |
数学 | 1450篇 |
物理学 | 4870篇 |
综合类 | 9069篇 |
出版年
2024年 | 53篇 |
2023年 | 267篇 |
2022年 | 527篇 |
2021年 | 587篇 |
2020年 | 606篇 |
2019年 | 465篇 |
2018年 | 434篇 |
2017年 | 512篇 |
2016年 | 644篇 |
2015年 | 831篇 |
2014年 | 1013篇 |
2013年 | 1177篇 |
2012年 | 1432篇 |
2011年 | 1469篇 |
2010年 | 1269篇 |
2009年 | 1249篇 |
2008年 | 1431篇 |
2007年 | 1233篇 |
2006年 | 1281篇 |
2005年 | 1073篇 |
2004年 | 795篇 |
2003年 | 614篇 |
2002年 | 589篇 |
2001年 | 553篇 |
2000年 | 529篇 |
1999年 | 481篇 |
1998年 | 390篇 |
1997年 | 316篇 |
1996年 | 301篇 |
1995年 | 273篇 |
1994年 | 268篇 |
1993年 | 197篇 |
1992年 | 202篇 |
1991年 | 170篇 |
1990年 | 144篇 |
1989年 | 136篇 |
1988年 | 111篇 |
1987年 | 98篇 |
1986年 | 69篇 |
1985年 | 45篇 |
1984年 | 40篇 |
1983年 | 33篇 |
1982年 | 22篇 |
1981年 | 24篇 |
1980年 | 18篇 |
1979年 | 9篇 |
1978年 | 11篇 |
1976年 | 12篇 |
1975年 | 9篇 |
1973年 | 8篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Dan Chen Kaixin Du Xiaochen Niu Hongwei Zhang Xue Zhang Yu Tang Jianchun Zhao 《Biomedical chromatography : BMC》2022,36(3):e5288
Amlexanox, an anti-inflammatory and anti-allergic agent, has been widely used clinically for the treatment of canker sores, asthma, and allergic rhinitis. Recently, amlexanox has received considerable attention in curing nonalcoholic fatty liver diseases and hepatitis virus infection. Herein, we first established a sensitive high-performance liquid chromatography-tandem mass spectrum (LC–MS/MS) method for the determination of amlexanox in rat plasma. Propranolol was used as the internal standard (IS). Using a simple protein precipitation method, the amlexanox and IS were separated with Capcell Pak C18 column (2.0 × 50 mm, 5 μm) and eluted with water and acetonitrile each containing 0.1% formic acid using gradient elution condition at a flow rate of 0.4 mL·min−1. Amlexanox and IS were detected by a triple quadrupole mass in multiple reactive monitoring (MRM) under the transitions of m/z 299.2 → 281.2 and m/z 259.9 → 116.1 with positive electrospray ionization, respectively. The calibration curves of amlexanox were established with the range of 50 to 2000 ng·mL−1 (r2 > 0.99). The validation method consisted of selectivity, accuracy, precision, carryover effect, matrix effect, recovery, dilution effect, and stability. The fully validated method was successfully applied to the pharmacokinetic study of amlexanox in Wistar rats. 相似文献
2.
Interactions of the vector breathers for the coupled Hirota system with $$4\times 4$$ 4 × 4 Lax pair
Nonlinear Dynamics - In this paper, we investigate the interactions of the vector breathers for the coupled Hirota system with $$4\times 4$$ Lax pair. Firstly, we give the first-order breather... 相似文献
3.
4.
The effects of PEA on the γ-phase PVDF crystal structure and the crystallization of PEA within the pre-existing γ-phase PVDF spherulites have been investigated by optical microscopy(OM), infrared spectroscopy(IR) and scanning electron microscopy(SEM). The results demonstrate that the γ-phase PVDF spherulites consist of the lamellae exhibiting a highly curved scroll-like morphology and develop preferentially in PEA-rich blend. With increasing PEA concentration, the scroll diameter increases and the scrolls are better separated from each other. PEA crystallizes first in the interspherulitic region and transcrystalline layer develops. Subsequently, the transcrystalline layer of PEA continues to grow within the γ-phase PVDF spherulites, e.g., in the region between the scrolls, until impinging on other PEA transcrystalline layers or spherulites. The crystallization kinetics results indicate that the growth rate of PEA crystals in the intraspherulitic region of γ-phase PVDF shows a positive correlation with content of PEA, but a negative one with the crystallization temperature of γ-phase PVDF. 相似文献
6.
Terahertz(THz) wave emission from argon atom in a two-color laser pulses is studied numerically by solving the one-dimensional(1D) time-dependent Schr ¨odinger equation. The THz spectra we obtained include both discontinuous and continuum ones. By using the special basis functions that we previously proposed, our analysis points out that the discontinuous and continuum parts are contributed by bound–bound and continuum–continuum transition of atomic energy levels. Although the atomic wave function is strongly dressed during the interaction with laser fields, our identification for the discontinuous part of the THz wave shows that the transition between highly excited bound states can still be well described by the field-free basis function in the tunneling ionization regime. 相似文献
7.
评价Actigraph GT3X三轴加速度传感器测量中国男性人群典型体力互动信效度,开发基于中国人群步行活动模式的GT3X三轴加速度传感器能耗推算方程。方法受试对象包括青年组(21.92±1.14岁),老年组(55.5±4.52岁)。受试者佩戴GT3X三轴加速度传感器,在跑台上分别完成3km/h(慢走)、4.5km/h(正常步行)、4.5km/h10%(上坡步行)、6km/h(快走)以及7.5km/h(慢跑)速度的走跑运动各5min。受试者佩戴COSMED K4b2便携式代谢测试仪,并将GT3X三轴加速度传感器佩戴于髋部,同步采集心肺功能仪及加速度传感器数据。结果根据受试对象4种无坡度走跑运动推导出线性方程MET=0.000653*counts(Axis1)+2.345521以及线性方程MET=0.000689*counts(VM)+1.640721,但其相关系数不高;GT3X+三轴加速度传感器记录上坡步行(4.5km/h10%)运动与无坡度运动(4.5km/h)相比,三轴counts及VM均显示有差异性(P<0.05),但counts增加率远低于MET增加率;GT3X+三轴加速度传感器两次重复测试,pearson值高,即离散程度低。结论本研究推导垂直轴(Axis1)、三轴矢量和(VM)的线性方程,为中度相关,误差值较大,且上坡运动时的GT3X+三轴加速度传感器记录counts值与MET值呈非线性相关,提示Actigraph GT3X三轴加速度传感器能耗推算方程可根据不同运动方式、运动强度推算相对应方程;Actigraph GT3X三轴加速度传感器测量我国成年及老年男性人群步行活动其信度较高。 相似文献
8.
从经济安全的角度,基于专利价值链理论,构建了一套专利风险评估指标体系,用于衡量一个国家或地区在专利活动中遭遇风险的程度。利用专利基本活动中的4个关键指标,即专利质量水平、专利转化能力、专利纠纷风险程度和专利贸易国际地位,对美国、日本、韩国、德国和中国进行比较分析,得出2006-2015年,中国的专利发展“快而不高”“大而不强”,但与其他专利强国相比,在专利价值链关键环节的竞争中,中国不占优势,甚至存在较为严重的风险,尤其专利使用费逆差越来越大,对国家经济安全存在一定程度的威胁。 相似文献
9.
10.
Jia Yang Xingang Li Wenjun Li Xin Xi Qian Du Feng Pan Songqing Liu 《Biomedical chromatography : BMC》2020,34(8):e4857
Because of its unpredictable side effects and efficacy, the anticancer drug docetaxel (DTX) requires improved characterisation of its pharmacokinetic profiles through population pharmacokinetic studies. A sensitive and rugged LC–MS/MS method for the detection of DTX in human plasma was developed and optimised using paclitaxel as an internal standard (IS). The plasma samples underwent rapid extraction using hybrid solid-phase extraction-protein precipitation. The analyte and IS were separated with an isocratic system on a Zorbax Eclipse Plus C18 column using water containing 0.05% acetic acid along with 20 μM of sodium acetate and methanol (30/70, v/v) as the mobile phase. Quantification was performed using a triple quadrupole mass spectrometer through multiple reaction monitoring in positive mode, using the m/z 830.3 → 548.8 and m/z 876.3 → 307.7 transitions for DTX and paclitaxel, respectively. The range of the calibration curve was 1–500 ng/mL for DTX, and the linear correlation coefficient was >0.99. The accuracies ranged from −4.6 to 4.2%, and the precision was no higher than 7.0% for the analytes. No significant matrix effect was observed. Both DTX and the IS showed considerable recovery. This method was finally applied to the establishment of a population pharmacokinetic model to optimise the clinical use of DTX. 相似文献