深亚微米工艺EEPROM单元加固设计及辐照性能

当普通EEPROM单元在太空中应用时,会受到辐照效应的影响,导致单元可靠性降低,寿命缩短,为此,基于0.18 μm工艺,设计出一种新型抗辐照EEPROM单元.新单元采用环形栅和场区隔离管加固结构.加固后,单元面积为9.56 μm2,抗总剂量效应能力大于1 500 Gy,抗辐照能力明显优于普通结构.为明确失效机制,基于新...     

丝素纤维/硫酸钙抗感染骨材料的制备及性能

通过控制丝素蛋白自组装过程制备了溶液状态下的丝素纳米纤维(silk fibroin nanofibers,SFFs),与硫酸钙、万古霉素(vancomycin,VCM)复合,制备了VCM/CS/SFFs抗菌骨材料。通过SEM、XRD、紫外分光光度计、万能力学试验机、抑菌圈、MTT等手段分别研究了复合材料的微观形貌与结构、药物释放、力学、抑菌及细胞相容性等性能。结果显示,与水作为固化液相比,随着SFFs溶液(0.017 5~2.1 mg·m L~(-1))的加入,复合材料凝固时间可控,降解率逐渐降低,抗水性增强,韧性提高;同时随丝素纳米纤维含量的增加骨材料抗压强度表现为先增加后减小的趋势,一周内药物释放速率降低;材料同时具有抑菌作用;MTT实验结果显示,加入丝素纳米纤维后与纯的硫酸钙相比MC3T3细胞增殖明显。     

丝素纤维/硫酸钙抗感染骨材料的制备及性能

通过控制丝素蛋白自组装过程制备了溶液状态下的丝素纳米纤维（silk fibroin nanofibers,SFFs）,与硫酸钙、万古霉素（vancomycin,VCM）复合,制备了VCM/CS/SFFs抗菌骨材料。通过SEM、XRD、紫外分光光度计、万能力学试验机、抑菌圈、MTT等手段分别研究了复合材料的微观形貌与结构、药物释放、力学、抑菌及细胞相容性等性能。结果显示,与水作为固化液相比,随着SFFs溶液（0.017 5~2.1 mg·mL^-1）的加入,复合材料凝固时间可控,降解率逐渐降低,抗水性增强,韧性提高;同时随丝素纳米纤维含量的增加骨材料抗压强度表现为先增加后减小的趋势,一周内药物释放速率降低;材料同时具有抑菌作用;MTT实验结果显示,加入丝素纳米纤维后与纯的硫酸钙相比MC3T3细胞增殖明显。     

Promoted Cytocompatibility of Silk Fibroin Fiber Vascular Graft through Chemical Grafting with Bioactive Molecules

Natural silk from Bombyx mori has been used as medical sutures for several decades,and regenerated silk fibroin( RSF)based biomaterials have been increasingly studied in the past thirty years. However,vascular graft derived from silk fibroin fiber has been explored in recent several years with development of textile science and engineering. Moreover,endothelialization of vascular graft has been seen as an ideal strategy for preventing thrombosis and getting higher patency in a long term. Therefore,in the present work silk fibroin fiber vascular graft( SF) was chemically grafted with bioactive molecules such as heparin and RSF to improve the cytocompatibility. 3-aminopropyl-triethoxysilane(APTES),1-ethyl-3-(3-dimethylaminopropyl) carbodiie hydrochlide( EDC · HCl),and N-hydroxysuccinimide( NHS) have been employed as coupling agent and crosslinking agents,respectively. Microscopy and ATRFTIR were used to characterize the surface changes and the structure of the grafts after treatment,respectively. Cell culture in vitro and MTT assay were conducted to determine the improvement of cell affinity to the graft. Furthermore,mechanical properties of the grafts before and after treatment were compared. The results showed that the chemical grafting was an effective method for improving the cytocompatibility of SF without significant loss of mechanical properties.     

纺织基人工血管的水渗透性

选用丝素和涤纶(PET)材料,分别制备了平纹和斜纹人工血管,测试并分析了在16kPa条件下,材料性质、组织结构、水浸润时间对人工血管水渗透性的影响.结果表明,在16kPa压强下,连续测量60min,无浸润丝素平纹人工血管的水渗透性呈现先快速下降而后平稳的变化趋势,而无浸润涤纶平纹人工血管的水渗透性变化不明显;两种斜纹人工血管的水渗透性远远高于平纹组织;随着浸润时间的延长,丝素平纹人工血管首分钟水渗透量显著降低,而涤纶平纹人工血管变化不明显.     

鸡源致病性大肠杆菌的分离鉴定及药敏试验

为了解鸡源致病性大肠杆菌的生物学特性和耐药性,试验通过采集病料、细菌分离培养、16S rRNA基因鉴定、致病性试验、药敏试验等方法。结果表明:分离出的20株细菌的培养特征、镜检特征均符合大肠杆菌特征;16S rRNA基因序列经BLAST比对与大肠杆菌同源性达99.9%～100%,确定20株分离菌为鸡源大肠杆菌;20株大肠杆菌的致病力为40%～100%;10株鸡源致病性大肠杆菌对15种抗菌药物均呈现多重耐药,耐药率为33.3%～93.3%,耐药情况较严重和复杂。     

A Sufficient Condition for Graphs to have 2-connected[2,4]-factors

ＡＳｕｆｉｃｉｅｎｔＣｏｎｄｉｔｉｏｎｆｏｒＧｒａｐｈｓｔｏｈａｖｅ２ｃｏｎｎｅｃｔｅｄ［２，４］ｆａｃｔｏｒｓＸｕＲｕｉ（徐睿）（ＳｃｈｏｏｌｏｆＭａｔｈｅｍａｔｉｃｓ＆ＳｙｓｔｅｍＳｃｉｅｎｃｅｓａｔＳｈａｎｄｏｎｇＵｎｉｖｅｒｓｉｔｙ，Ｊｉ...     

基于知识管理的知识服务探析

探讨了知识管理与图书馆知识服务的内在联系,提出了图书馆开展基于知识管理的知识服务的对策。     

基于TDLAS的近红外甲烷高灵敏检测技术

为增强甲烷气体检测技术的气体吸收率,提高检测灵敏度,利用可调谐二极管激光吸收光谱技术,采用中心波长为1 653.7 nm的分布反馈激光器作为光源,研制了有效光程为14.5 m的Herriott型气体吸收池,并采用波长调制光谱法进行甲烷气体浓度检测。结果表明,二次谐波峰值信号与甲烷气体浓度成较强的线性关系,线性度为0.998 52,检测下限为4.82 ppm;初始积分时间为1 s时的Allan方差为6.37 ppm;积分时间到112 s时,Allan方差为427 ppb,检测灵敏度为4.27×10^-7。     

A stereoselective synthesis of the C(3)-C(13) and C(14)-C(24) fragments of macrolactin A

Synthetic studies towards(he C(3)-C(13)and C(14)-C(24)segments(3,4)of the potent antiviral and antitumor compound macrolactin A(1)are presented.Compound 3 was constructed via a convergent and facile approach,exploiting Wittig olefination to generate the sensitive E,Z-diene moiety.Compound 4 was synthesized from the chiral-pod derived sul-fone 39a via an o-alkylation-desulfonation reaction sequence.Cu(Ⅱ)-catalyzed coupling of a Grignard reagent with an al-lylic bromide and Julia olefination were also investigated for the preparation of compound 4.