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排序方式: 共有3519条查询结果,搜索用时 615 毫秒
1.
Hongjin Wang Tengfei Long Hao Zhang Meng Li Qi Sun Xin Zhai Lixin Sun 《Biomedical chromatography : BMC》2022,36(4):e5301
3,4-Difluorobenzyl(1-ethyl-5-(4-((4-hydroxypiperidin-1-yl)-methyl)thiazol-2-yl)-1H-indol-3-yl)carbamate (NAI59), a small molecule with outstanding therapeutic effectiveness to anti-pulmonary fibrosis, was developed as an autotaxin inhibitor candidate compound. To evaluate the pharmacokinetics and plasma protein binding of NAI59, a UPLC–MS/MS method was developed to quantify NAI59 in plasma and phosphate-buffered saline. The calibration curve linearity ranged from 9.95 to 1990.00 ng/mL in plasma. The accuracy was −6.8 to 5.9%, and the intra- and inter-day precision was within 15%. The matrix effect and recovery, as well as dilution integrity, were within the criteria. The chromatographic and mass spectrometric conditions were also feasible to determine phosphate-buffered saline samples, and it has been proved that this method exhibits good precision and accuracy in the range of 9.95–497.50 ng/mL in phosphate-buffered saline. This study is the first to determine the pharmacokinetics, absolute bioavailability, and plasma protein binding of NAI59 in rats using this established method. Therefore, the pharmacokinetic profiles of NAI59 showed a dose-dependent relationship after oral administration, and the absolute bioavailability in rats was 6.3%. In addition, the results of protein binding showed that the combining capacity of NAI59 with plasma protein attained 90% and increased with the increase in drug concentration. 相似文献
2.
Xinghua Li Yuqin Yang Junjie Miao Zhendong Yin Yijing Zhai Hongmei Shi Zengning Li 《Electrophoresis》2020,41(18-19):1584-1591
In the present research, field-amplified sample injection–CZE (FASI–CZE) coupled with a diode array detector was established to determine trace level sulfa antibiotic. Sulfathiazole, sulfadiazine, sulfamethazine, sulfadimethoxine, sulfamethoxazole, and sulfisoxazole were selected as analytes for the experiments. The background electrolyte solution consisted of 70.0 mmol/L borax and 60.0 mmol/L boric acid (including 10% methanol, pH 9.1). The plug was 2.5 mmol/L borax, which was injected into the capillary at a pressure of 0.5 psi for 5 s. Then the sample was injected into the capillary at an injection voltage of –10 kV for 20 s. The electrophoretic separation was carried out under a voltage of +19 kV. The capillary temperature was maintained at 20˚C throughout the analysis, and six sulfonamides were completely separated within 35 min. Compared with pressure injection-CZE, the sensitivity of FASI-CZE was increased by 6.25–10.0 times, and the LODs were reduced from 0.2–0.5 to 0.02–0.05 μg/mL. The method was applied to the determination of sulfonamides in river water and particulate matter samples. The recoveries were 78.59–106.59%. The intraday and interday precisions were 2.89–7.35% and 2.77–7.09%, respectively. This provides a simpler and faster method for the analysis of sulfa antibiotic residues in environmental samples. 相似文献
3.
Analysis and pharmacokinetic study of polyphyllin H in beagle dog plasma after oral administration of Rhizoma Paridis Extracts by LC‐MS/MS
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4.
A new spectral problem is proposed, and nonlinear differential equations of the corresponding hierarchy are obtained. With the help of the nonlinearization appr... 相似文献
5.
6.
Quality of service (QoS) support for multimedia services in the IEEE 802.11 wireless LAN is an important issue for such WLANs
to become a viable wireless access to the Internet. In this paper, we endeavor to propose a practical scheme to achieve this
goal without changing the channel access mechanism. To this end, a novel call admission and rate control (CARC) scheme is
proposed. The key idea of this scheme is to regulate the arriving traffic of the WLAN such that the network can work at an
optimal point. We first show that the channel busyness ratio is a good indicator of the network status in the sense that it
is easy to obtain and can accurately and timely represent channel utilization. Then we propose two algorithms based on the
channel busyness ratio. The call admission control algorithm is used to regulate the admission of real-time or streaming traffic
and the rate control algorithm to control the transmission rate of best effort traffic. As a result, the real-time or streaming
traffic is supported with statistical QoS guarantees and the best effort traffic can fully utilize the residual channel capacity
left by the real-time and streaming traffic. In addition, the rate control algorithm itself provides a solution that could
be used above the media access mechanism to approach the maximal theoretical channel utilization. A comprehensive simulation
study in ns-2 has verified the performance of our proposed CARC scheme, showing that the original 802.11 DCF protocol can
statically support strict QoS requirements, such as those required by voice over IP or streaming video, and at the same time,
achieve a high channel utilization.
Hongqiang Zhai received the B.E. and M.E. degrees in electrical engineering from Tsinghua University, Beijing, China, in July 1999 and January
2002 respectively. He worked as a research intern in Bell Labs Research China from June 2001 to December 2001, and in Microsoft
Research Asia from January 2002 to July 2002. Currently he is pursuing the PhD degree in the Department of Electrical and
Computer Engineering, University of Florida. He is a student member of IEEE.
Xiang Chen received the B.E. and M.E. degrees in electrical engineering from Shanghai Jiao Tong University, Shanghai, China, in 1997
and 2000, respectively, and the Ph.D. degree in electrical and computer engineering from the University of Florida, Gainesville,
in 2005. He is currently a Senior Research Engineer at Motorola Labs, Arlington Heights, IL. His research interests include
resource management, medium access control, and quality of service (QoS) in wireless networks. He is a Member of Tau Beta
Pi and a student member of IEEE.
Yuguang Fang received a Ph.D degree in Systems and Control Engineering from Case Western Reserve University in January 1994, and a Ph.D
degree in Electrical Engineering from Boston University in May 1997.
From June 1997 to July 1998, he was a Visiting Assistant Professor in Department of Electrical Engineering at the University
of Texas at Dallas. From July 1998 to May 2000, he was an Assistant Professor in the Department of Electrical and Computer
Engineering at New Jersey Institute of Technology. In May 2000, he joined the Department of Electrical and Computer Engineering
at University of Florida where he got the early promotion with tenure in August 2003 and has been an Associate Professor since
then. He has published over one hundred (100) papers in refereed professional journals and conferences. He received the National
Science Foundation Faculty Early Career Award in 2001 and the Office of Naval Research Young Investigator Award in 2002.
He is currently serving as an Editor for many journals including IEEE Transactions on Communications, IEEE Transactions on
Wireless Communications, IEEE Transactions on Mobile Computing, and ACM Wireless Networks. He is also actively participating
in conference organization such as the Program Vice-Chair for IEEE INFOCOM’2005, Program Co-Chair for the Global Internet
and Next Generation Networks Symposium in IEEE Globecom’2004 and the Program Vice Chair for 2000 IEEE Wireless Communications
and Networking Conference (WCNC’2000). 相似文献
7.
AT89C51单片机在电话远程控制器中的应用 总被引:6,自引:0,他引:6
设计以AT89C51单片机作为控制核心的电话远程控制器,重点介绍该控制器的各模块组成、原理及具体实现的电路,该控制器采用现有的电话线路进行通信,无需重新布线且通信距离不受限制,经实际运行表明,该控制器具有运行可靠、成本低、操作方便,适用性强的特点、可以广泛应用于城市社区,具有较大的推广价值。 相似文献
8.
基于校园网的实验管理系统的设计 总被引:2,自引:1,他引:1
主要讨论了应用实验室管理系统的必要性,并从用户需求分析、系统总体设计、功能模块的设计等方面对B/S实验室管理系统的开发进行了详细的阐述。 相似文献
9.
Software failures have become the major factor that brings the system down or causes a degradation in the quality of service. For many applications, estimating the software failure rate from a user's perspective helps the development team evaluate the reliability of the software and determine the release time properly. Traditionally, software reliability growth models are applied to system test data with the hope of estimating the software failure rate in the field. Given the aggressive nature by which the software is exercised during system test, as well as unavoidable differences between the test environment and the field environment, the resulting estimate of the failure rate will not typically reflect the user‐perceived failure rate in the field. The goal of this work is to quantify the mismatch between the system test environment and the field environment. A calibration factor is proposed to map the failure rate estimated from the system test data to the failure rate that will be observed in the field. Non‐homogeneous Poisson process models are utilized to estimate the software failure rate in both the system test phase and the field. For projects that have only system test data, use of the calibration factor provides an estimate of the field failure rate that would otherwise be unavailable. For projects that have both system test data and previous field data, the calibration factor can be explicitly evaluated and used to estimate the field failure rate of future releases as their system test data becomes available. Copyright © 2002 John Wiley & Sons, Ltd. 相似文献
10.
Herein we report a new method to collect a qualified infrared spectrum of a solute in solution by two solvent cells with different thickness during background single-beam spectrum scanning. By collecting the background spectrum with two cells (two stages), we successfully achieved accurate solvent compensation between a sample and a reference, namely, the solvent amounts in the sample and background measurements could become congruent. Therefore, the solvent bands were thoroughly suppressed in the infrared spectrum and a qualified spectrum of the solute was obtained. 相似文献