排序方式: 共有48条查询结果,搜索用时 453 毫秒
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Locke Davenport Huyer Serena Mandla Yufeng Wang Scott B. Campbell Bess Yee Christian Euler Benjamin F. Lai A. Dawn Bannerman Dawn S. Y. Lin Miles Montgomery Kayla Nemr Timothy Bender Slava Epelman Radhakrishnan Mahadevan Milica Radisic 《Advanced functional materials》2021,31(6):2003341
Itaconate (ITA) is an emerging powerhouse of innate immunity with therapeutic potential that is limited in its ability to be administered in a soluble form. A library of polyester materials that incorporate ITA into polymer backbones resulting in materials with inherent immunoregulatory behavior is developed. Harnessing hydrolytic degradation release from polyester backbones, ITA polymers result in the mechanism specific immunoregulatory properties on macrophage polarization in vitro. In a functional assay, the polymer-released ITA inhibits bacterial growth on acetate. Translation to an in vivo model of biomaterial associated inflammation, intraperitoneal injection of ITA polymers demonstrate a rapid resolution of inflammation in comparison to a control polymer silicone, demonstrating the value of sustained biomimetic presentation of ITA. 相似文献
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M. Sc. Vincent Eschenbrenner‐Lux Dipl.‐Biol. Philipp Küchler Dr. Slava Ziegler Dr. Kamal Kumar Prof. Herbert Waldmann 《Angewandte Chemie (International ed. in English)》2014,53(8):2134-2137
The imino Diels–Alder reaction is an efficient method for the synthesis of aza‐heterocycles. While different stereo‐ and enantioselective inverse‐electron‐demand imino Diels–Alder (IEDIDA) reactions have been reported before, IEDIDA reactions including electron‐deficient dienes are unprecedented. The first enantioselective IEDIDA reaction between electron‐poor chromone dienes and cyclic imines, catalyzed by zinc/binol complexes is described. The novel reaction provides a facile entry to a natural product inspired collection of ring‐fused quinolizines including a potent modulator of mitosis. 相似文献
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Lyapunov exponents as a criterion for the dynamic pull-in instability of electrostatically actuated microstructures 总被引:1,自引:0,他引:1
Slava Krylov 《International Journal of Non》2007,42(4):626-642
The dynamic pull-in instability of double clamped microscale beams actuated by a suddenly applied distributed electrostatic force and subjected to non-linear squeeze film damping is investigated. A reduced order model is built using the Galerkin decomposition with undamped linear modes as base functions and verified through comparison with numerical finite differences solution. The stability analysis of a beam actuated by one and two electrodes symmetrically located at two sides of the beam and operated by a step-input voltage is performed by evaluating the largest Lyapunov exponent, the sign of which defines the character of the response. It is shown that this approach provides an efficient quantitative criterion for the evaluation of dynamic pull-in instability, especially when combined with compact reduced order models. Based on the Lyapunov exponent criterion, the influence of various parameters on the beam dynamic stability is investigated. 相似文献
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Biology‐Oriented Synthesis of a Withanolide‐Inspired Compound Collection Reveals Novel Modulators of Hedgehog Signaling
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Dr. Jakub Švenda Dipl.‐Biochem. Michael Sheremet M. Sc. Lea Kremer Lukáš Maier Dr. Jonathan O. Bauer Prof. Dr. Carsten Strohmann Dr. Slava Ziegler Dr. Kamal Kumar Prof. Dr. Herbert Waldmann 《Angewandte Chemie (International ed. in English)》2015,54(19):5596-5602
Biology‐oriented synthesis employs the structural information encoded in complex natural products to guide the synthesis of compound collections enriched in bioactivity. The trans‐hydrindane dehydro‐δ‐lactone motif defines the characteristic scaffold of the steroid‐like withanolides, a plant‐derived natural product class with a diverse pattern of bioactivity. A withanolide‐inspired compound collection was synthesized by making use of three key intermediates that contain this characteristic framework derivatized with different reactive functional groups. Biological evaluation of the compound collection in cell‐based assays that monitored biological signal‐transduction processes revealed a novel class of Hedgehog signaling inhibitors that target the protein Smoothened. 相似文献
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M. Sc. Yasemin Akbulut Hannah J. Gaunt Prof. Katsuhiko Muraki Dr. Melanie J. Ludlow Dr. Mohamed S. Amer Dr. Alexander Bruns Dr. Naveen S. Vasudev Dr. Lea Radtke Dr. Matthieu Willot M. Sc. Sven Hahn M. Sc. Tobias Seitz Dr. Slava Ziegler Prof. Dr. Mathias Christmann Prof. Dr. David J. Beech Prof. Dr. Herbert Waldmann 《Angewandte Chemie (International ed. in English)》2015,54(12):3787-3791
Current therapies for common types of cancer such as renal cell cancer are often ineffective and unspecific, and novel pharmacological targets and approaches are in high demand. Here we show the unexpected possibility for the rapid and selective killing of renal cancer cells through activation of calcium‐permeable nonselective transient receptor potential canonical (TRPC) calcium channels by the sesquiterpene (?)‐englerin A. This compound was found to be a highly efficient, fast‐acting, potent, selective, and direct stimulator of TRPC4 and TRPC5 channels. TRPC4/5 activation through a high‐affinity extracellular (?)‐englerin A binding site may open up novel opportunities for drug discovery aimed at renal cancer. 相似文献
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Lea Kremer Elisabeth Hennes Alexandra Brause Andrei Ursu Lucas Robke Hideaki T. Matsubayashi Yuta Nihongaki Jana Flegel Ivana Mejdrov Jan Eickhoff Matthias Baumann Radim Nencka Petra Janning Susanne Kordes Hans R. Schler Jared Sterneckert Takanari Inoue Slava Ziegler Herbert Waldmann 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2019,131(46):16770-16781