Studies on metabolism of total glucosides of paeony from Paeoniae Radix Alba in rats by UPLC‐Q‐TOF‐MS/MS

Total glucosides of paeony are the active constituents of Paeoniae Radix Alba. In this study, a novel strategy was proposed to find more metabolites and the differences between paeoniflorin, albiflorin and total glucosides of paeony (TGP). This strategy was characterized as follows: firstly, the animals were divided into three groups (paeoniflorin, albiflorin and TGP) to identify the source of TGP metabolites from paeoniflorin or albiflorin; secondly, a generic information‐dependent acquisition scan for the low‐level metabolites was triggered by the multiple mass defect filter and dynamic background subtraction; thirdly, the metabolites were identified with a combination of data‐processing methods including mass defect filtering, neutral loss filtering and product ion filtering; finally, a comparative study was used in the metabolism of paeoniflorin, albiflorin and TGP. Based on the strategy, 18 metabolites of TGP, 10 metabolites of paeoniflorin and 13 metabolites of albiflorin were identified respectively. The results indicated that the hydrolysis, conjugation reaction and oxidization were the major metabolic pathways, and the metabolic sites were the glycosidic linkage, the ester bond and the benzene ring. This study is first to explore the metabolism of TGP, and these findings enhance our understanding of the metabolism and the interactions of paeoniflrin and albiflorin in TGP. Copyright © 2015 John Wiley & Sons, Ltd.     

A model study for the steady state error of numerical approximations of inviscid flow equations on Cartesian grid

The widely used locally adaptive Cartesian grid methods involve a series of abruptly refined interfaces. In this paper we consider the influence of the refined interfaces on the steady state errors for second‐order three‐point difference approximations of flow equations. Since the various characteristic components of the Euler equations should behave similarly on such grids with regard to refinement‐induced errors, it is sufficient enough to conduct the analysis on a scalar model problem. The error we consider is a global error, different to local truncation error, and reflects the interaction between multiple interfaces. The steady state error will be compared to the errors on smooth refinement grids and on uniform grids. The conclusion seems to support the numerical findings of Yamaleev and Carpenter (J. Comput. Phys. 2002; 181: 280–316) that refinement does not necessarily reduce the numerical error. Copyright © 2005 John Wiley & Sons, Ltd.     

Target Location Estimation in Sensor Networks With Quantized Data

A signal intensity based maximum-likelihood (ML) target location estimator that uses quantized data is proposed for wireless sensor networks (WSNs). The signal intensity received at local sensors is assumed to be inversely proportional to the square of the distance from the target. The ML estimator and its corresponding Crameacuter-Rao lower bound (CRLB) are derived. Simulation results show that this estimator is much more accurate than the heuristic weighted average methods, and it can reach the CRLB even with a relatively small amount of data. In addition, the optimal design method for quantization thresholds, as well as two heuristic design methods, are presented. The heuristic design methods, which require minimum prior information about the system, prove to be very robust under various situations     

PVC敏感膜组分比对K~＋─ISFET响应特性的影响

本文研究了以二苯并—３０—冠—１０作为敏感物质的ＰＶＣ膜Ｋ~＋—ＩＳＦＥＴ传感器，以及改变膜中的敏感物质和增塑剂的组分比对Ｋ~＋—ＩＳＦＥＴ响应特性的影响．同时，对Ｋ~＋敏感膜的响应机理进行了讨论。实验结果与理论分析相符。     

方位伺服系统扭转振动固有频率的分析

本文阐述了伺服系统结构设计中估算系统固有频率的必要性,介绍了一种分析和计算经纬仪方位伺服系统扭转振动固有频率的方法。     

激光对望远系统损伤的研究

本文对激光光束通过望远系统后光束的变化进行了分析，并对６倍望远镜进行了激光损伤和破坏的实验研究，实验结果表明，激光对望远系统的损伤破坏主要是热效应所致，损伤破坏的情况与激光的能量，波长，脉冲宽度和望远系统的结构有关。     

DIELS-ALDER REACTIONS OF FURAN WITH DIENOPHILES CATALYZED BY YbCl3

The yield and stereoselectivity of the Diels-Alder reactions between furan(or 2-methylfuran)and different dienophiles are markedly enhanced by the catalysis of anhydrous YbCl₃.     

Representing workloads in GI/G/1 queues through the preemptive-resume LIFO queue discipline

We give in this paper a detailed sample-average analysis of GI/G/1 queues with the preemptive-resume LIFO (last-in-first-out) queue discipline: we study the long-run state behavior of the system by averaging over arrival epochs, departure epochs, as well as time, and obtain relations that express the resulting averages in terms of basic characteristics within busy cycles. These relations, together with the fact that the preemptive-resume LIFO queue discipline is work-conserving, imply new representations for both actual and virtual delays in standard GI/G/1 queues with the FIFO (first-in-first-out) queue discipline. The arguments by which our results are obtained unveil the underlying structural explanations for many classical and somewhat mysterious results relating to queue lengths and/or delays in standard GI/G/1 queues, including the well-known Bene's formula for the delay distribution in M/G/l. We also discuss how to extend our results to settings more general than GI/G/1.