Distribution of recombination currents in the space charge regionof heterostructure bipolar devices

This paper addresses the problem of the space charge region Shockley-Read-Hall (SRH) recombination currents in heterojunctions with one noncrystalline side. A formulation which generalizes previous works is discussed. The approach is based on the drift-diffusion model with a thermionic-field emission boundary condition. The main physical parameters which determine the relative contribution of each zone of the space charge region (SCR) to the total recombination current are identified. The general analysis is applied for the first time to amorphous/crystalline heterojunctions and design criteria are established to minimize the total recombination current     

<Emphasis Type="Italic">parkin</Emphasis> counteracts symptoms in a <Emphasis Type="Italic">Drosophila</Emphasis> model of Parkinson's disease

Background

Parkinson's disease, a prevalent neurodegenerative disease, is characterized by the reduction of dopaminergic neurons resulting in the loss of motor control, resting tremor, the formation of neuronal inclusions and ultimately premature death. Two inherited forms of PD have been linked to mutations in the α-synuclein and parkin genes. The parkin protein functions as an ubiquitin ligase targeting specific proteins for degradation. Expression of human α-synuclein in Drosophila neurons recapitulates the loss of motor control, the development of neuronal inclusions, degeneration of dopaminergic neurons and the ommatidial array to provide an excellent genetic model of PD.

Results

To investigate the role of parkin, we have generated transgenic Drosophila that conditionally express parkin under the control of the yeast UAS enhancer. While expression of parkin has little consequence, co-expression of parkin with α-synuclein in the dopaminergic neurons suppresses the α-synuclein-induced premature loss of climbing ability. In addition directed expression of parkin in the eye counteracts the α-synuclein-induced degeneration of the ommatidial array. These results show that parkin suppresses the PD-like symptoms observed in the α-synuclein-dependent Drosophila model of PD.

Conclusion

The highly conserved parkin E3 ubiquitin ligase can suppress the damaging effects of human α-synuclein. These results are consistent with a role for parkin in targeting α-synuclein to the proteasome. If this relationship is conserved in humans, this suggests that up-regulation of parkin should suppress α-synucleinopathic PD. The development of therapies that regulate parkin activity may be crucial in the treatment of PD.

     

Liquid-crystalline phase behavior of a colloidal rod-plate mixture

The phase behavior of rod-plate mixtures was investigated using model systems containing unambiguously rod- and plate-shaped colloids. We find that the theoretically disputed biaxial nematic phase is unstable with respect to demixing into an isotropic and two uniaxial nematic phases. The phase behavior at very high densities is exceptionally rich and includes the coexistence of up to four different liquid crystalline phases, which stem from the coupling between the employed particle shapes and polydispersity.     

A continuous-time /spl Sigma//spl Delta/ ADC with increased immunity to interferers

Receivers are being digitized in a quest for flexibility. Analog filters and programmable gain stages are being exchanged for digital processing at the price of a very challenging ADC. This paper presents an alternative solution where the filter and programmable gain functionality is integrated into a /spl Sigma//spl Delta/ ADC. The novel filtering ADC is realized by adding a high-pass feedback path to a conventional /spl Sigma//spl Delta/ ADC while a compensating low-pass filter in the forward path maintains stability. As such, the ADC becomes highly immune to interferers even if they exceed the maximum allowable input level for the wanted channel. As a consequence, the ADC input range can be programmed dynamically to the level of the wanted signal only. This results in an input-referred dynamic range of 89 dB in 1-MHz bandwidth and an intentionally moderate output signal-to-noise-and-distortion ratio of 46-59 dB (depending on the programmed gain). The merged functionality enables a better overall power/performance balance for the receiver baseband. The design consumes less than 2 mW and active area is 0.14 mm/sup 2/ in a 0.18-/spl mu/m digital CMOS technology.     

Transient natural convection cooling of a high Prandtl number fluid in a cubical cavity

This work presents a numerical analysis of the effects of thermal boundary conditions, fluid variable viscosity and wall conduction on transient laminar natural convection of a high Prandtl number (Pr=4×10⁴) fluid (Golden Syrup) in a cubical cavity. The simulations consider physical situations realizable at laboratory scale using a cavity with Plexiglas walls of 1 cm of thickness, and inside dimension of L=20 cm. The initial Rayleigh (Ra) number is 10⁶. The cavity is initially full of fluid at rest and at constant temperature (T _i =45°C) higher than the temperature of the walls (T _w =25°C). The time evolution of the flow patterns, the temperature contours, the mean temperature of the fluid and the Nusselt number (Nu) of eight different cases of cooling are presented and analyzed.     

DC SPICE model for nanocrystalline and microcrystalline silicon TFTs

In this paper, we present a physically-based analytical model for n-channel nanocrystalline and microcrystalline thin-film transistors suitable for implementation in circuit simulators such as SPICE. The model is based on existing models for amorphous silicon thin film transistors, which have been extended to account for observed physical phenomena in nanocrystalline and microcrystalline thin film transistors. The proposed model has been verified for the most important regions of operation of the devices and has shown good agreement with experimental data.     

Cross-sections for deuteron photo-disintegration from 139 to 832 MeV

The cross-sections for deuteron photo-disintegration have been measured at nine c.m. angles from 37 to 143 degrees. The minimum and maximum photon energies have been 139 and 832 MeV respectively. The results are in agreement with earlier data above 300 MeV, but are significantly larger below 200 MeV, the discrepancies being up to 50% at the lowest energies measured.     

Design and implementation of a lightweight online certificate validation service

A PKI (public key infrastructure) provides for a digital certificate that can identify an individual or an organization. However, the existence of a certificate is a necessary but not sufficient evidence for its validity. The PKI needs to provide applications that use certificates with the ability to validate, at the time of usage, that a certificate is still valid (not revoked). One of the two standard protocols to check the revocation status of certificates is the Online Certificate Status Protocol (OCSP). In this article, we propose an OCSP-based implementation that enhances the performance of standard OCSP. In particular, we put special emphasis on those issues that affect security and performance when the validation service is deployed in a real scenario. Finally, we provide experimental results that show that our implementation outperforms standard OCSP.