全文获取类型
收费全文 | 140637篇 |
免费 | 34508篇 |
国内免费 | 28782篇 |
专业分类
化学 | 74493篇 |
晶体学 | 1399篇 |
力学 | 7604篇 |
综合类 | 271篇 |
数学 | 14207篇 |
物理学 | 64219篇 |
无线电 | 41734篇 |
出版年
2024年 | 807篇 |
2023年 | 2547篇 |
2022年 | 2698篇 |
2021年 | 3165篇 |
2020年 | 3542篇 |
2019年 | 4648篇 |
2018年 | 4198篇 |
2017年 | 4864篇 |
2016年 | 6114篇 |
2015年 | 6839篇 |
2014年 | 7058篇 |
2013年 | 9424篇 |
2012年 | 10683篇 |
2011年 | 11440篇 |
2010年 | 13085篇 |
2009年 | 12831篇 |
2008年 | 7079篇 |
2007年 | 6262篇 |
2006年 | 5915篇 |
2005年 | 5588篇 |
2004年 | 5870篇 |
2003年 | 4828篇 |
2002年 | 4603篇 |
2001年 | 4487篇 |
2000年 | 3646篇 |
1999年 | 3794篇 |
1998年 | 3257篇 |
1997年 | 3002篇 |
1996年 | 3392篇 |
1995年 | 3568篇 |
1994年 | 3486篇 |
1993年 | 3469篇 |
1992年 | 3069篇 |
1991年 | 2690篇 |
1990年 | 2183篇 |
1989年 | 2230篇 |
1988年 | 2057篇 |
1987年 | 1310篇 |
1986年 | 1362篇 |
1985年 | 998篇 |
1984年 | 1081篇 |
1982年 | 953篇 |
1981年 | 784篇 |
1980年 | 814篇 |
1979年 | 554篇 |
1978年 | 560篇 |
1977年 | 660篇 |
1976年 | 1072篇 |
1973年 | 464篇 |
1972年 | 555篇 |
排序方式: 共有10000条查询结果,搜索用时 531 毫秒
1.
2.
3.
Experimental Mechanics - Temperature gradients significantly affect the material fatigue process. A reliable and robust test procedure is needed for quantifying the effects of temperature gradients... 相似文献
4.
5.
Jia Dai Xiang Cheng Xiaofeng Li Zhisheng Wang Yufeng Wang Jing Zheng Jun Liu Jiawei Chen Changjin Wu Jinyao Tang 《Advanced functional materials》2021,31(48):2106204
Synthetic active matters are perfect model systems for non-equilibrium thermodynamics and of great potential for novel biomedical and environmental applications. However, most applications are limited by the complicated and low-yield preparation, while a scalable synthesis for highly functional microswimmers is highly desired. In this paper, an all-solution synthesis method is developed where the gold-loaded titania-silica nanotree can be produced as a multi-functional self-propulsion microswimmer. By applying light, heat, and electric field, the Janus nanotree demonstrated multi-mode self-propulsion, including photochemical self-electrophoresis by UV and visible light radiation, thermophoresis by near-infrared light radiation, and induced-charge electrophoresis under AC electric field. Due to the scalable synthesis, the Janus nanotree is further demonstrated as a high-efficiency, low-cost, active adsorbent for water decontamination, where the toxic mercury ions can be reclaimed with enhanced efficiency. 相似文献
6.
Kobayashi M. Zhang Y. Ishikawa H. Sun J. Oddershede J. Juul Jensen D. Miura H. 《Experimental Mechanics》2021,61(5):817-828
Experimental Mechanics - The internal strain distribution developing during plastic deformation is important for understanding the mechanical properties of polycrystalline materials. Such... 相似文献
7.
Journal of Signal Processing Systems - With the latest development of automation technology, object detection technology has received more and more research attention. Automated object detection... 相似文献
8.
Ping Xiao Jue Wang Lei Fang Zitong Zhao Xiangshi Sun Xiaochen Liu Haiqiang Cao Pengcheng Zhang Dangge Wang Yaping Li 《Advanced functional materials》2021,31(36):2104068
Neoantigen vaccines and adoptive dendritic cell (DC) transfer are major clinical approaches to initiate personalized immunity in cancer patients. However, the immunization efficacy is largely limited by the in vivo trajectory including neoantigens’ access to resident DCs and DCs’ access to lymph nodes (LNs). Herein, an innovative strategy is proposed to improve personalized immunization through neoantigen-loaded nanovaccines synergized with adoptive DC transfer. It is found that it enables selective delivery of neoantigens to resident DCs and macrophages by coating cancer cell membranes onto neoantigen-loaded nanoparticles. In addition, the nanovaccines promote the secretion of chemokine C-C motif ligand 2 (CCL2), CCL3, and C-X-C motif ligand 10 from macrophages, thus potentiating the access of transferred DCs to LNs. This immunization strategy enables coordinated delivery of identified neoantigens and autologous tumor lysate-derived undefined antigens, leading to initiation of antitumor T cell immunity in a personalized manner. It significantly inhibits tumor growth in prophylactic and established mouse tumor models. The findings provide a new vision for potentiating adoptive cell transfer by nanovaccines, which may open the door to a transformative possibility for improving personalized immunization. 相似文献
9.
Li Quanxin Li Zheng He Cheng Sun Huilin Tan Shengheng Zhang Hua 《Journal of Radioanalytical and Nuclear Chemistry》2022,331(5):2105-2115
Journal of Radioanalytical and Nuclear Chemistry - The simplified 8-oxide system (SiO2-B2O3-Na2O-Al2O3-CaO-TiO2-MoO3-La2O3) has been prepared under two types of cooling methods, and analyzed with... 相似文献
10.
Hongjin Wang Tengfei Long Hao Zhang Meng Li Qi Sun Xin Zhai Lixin Sun 《Biomedical chromatography : BMC》2022,36(4):e5301
3,4-Difluorobenzyl(1-ethyl-5-(4-((4-hydroxypiperidin-1-yl)-methyl)thiazol-2-yl)-1H-indol-3-yl)carbamate (NAI59), a small molecule with outstanding therapeutic effectiveness to anti-pulmonary fibrosis, was developed as an autotaxin inhibitor candidate compound. To evaluate the pharmacokinetics and plasma protein binding of NAI59, a UPLC–MS/MS method was developed to quantify NAI59 in plasma and phosphate-buffered saline. The calibration curve linearity ranged from 9.95 to 1990.00 ng/mL in plasma. The accuracy was −6.8 to 5.9%, and the intra- and inter-day precision was within 15%. The matrix effect and recovery, as well as dilution integrity, were within the criteria. The chromatographic and mass spectrometric conditions were also feasible to determine phosphate-buffered saline samples, and it has been proved that this method exhibits good precision and accuracy in the range of 9.95–497.50 ng/mL in phosphate-buffered saline. This study is the first to determine the pharmacokinetics, absolute bioavailability, and plasma protein binding of NAI59 in rats using this established method. Therefore, the pharmacokinetic profiles of NAI59 showed a dose-dependent relationship after oral administration, and the absolute bioavailability in rats was 6.3%. In addition, the results of protein binding showed that the combining capacity of NAI59 with plasma protein attained 90% and increased with the increase in drug concentration. 相似文献