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Abstract Gastrodigenin, also known as 4-hydroxybenzyl alcohol (HBA), is one of the main components of Gastrodia elata, which is a perfect lead compound of natural products. In order to get new active compounds, we modified the structure of HBA through esterification with carboxylic acid, and got a series of derivatives in which 4-hydroxybenzyl alcohol 2-naphthoate (NHBA) showed stronger antidepressant activity than HBA. In this paper, we firstly evaluated the antidepressant activity of NHBA by tail suspension test (TST) and forced swimming test (FST). Then, we carried out the biochemical assay and western blot to determine its mechanism. The results displayed that NHBA could increase the content of serotonin, dopamine, norepinephrine, γ-aminobutyric acid, brain-derived neurotrophic factor (BDNF) and tropomyosin receptor kinase B (TrkB) in mice brain. It suggested that NHBA exhibited an antidepressant-like effect through monoaminergic system, GABAergic system and BDNF/TrkB signaling pathways. 相似文献
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Shaobo Cheng Vidushi Sharma Altug S. Poyraz Lijun Wu Xing Li Amy C. Marschilok Esther S. Takeuchi Kenneth J. Takeuchi Marivi Fernndez-Serra Yimei Zhu 《Chemical science》2020,11(19):4991
Tunneled metal oxides such as α-Mn8O16 (hollandite) have proven to be compelling candidates for charge-storage materials in high-density batteries. In particular, the tunnels can support one-dimensional chains of K+ ions (which act as structure-stabilizing dopants) and H2O molecules, as these chains are favored by strong H-bonds and electrostatic interactions. In this work, we examine the role of water molecules in enhancing the stability of K+-doped α-Mn8O16 (cryptomelane). The combined experimental and theoretical analyses show that for high enough concentrations of water and tunnel-ions, H2O displaces K+ ions from their natural binding sites. This displacement becomes energetically favorable due to the formation of K2+ dimers, thereby modifying the stoichiometric charge of the system. These findings have potentially significant technological implications for the consideration of cryptomelane as a Li+/Na+ battery electrode. Our work establishes the functional role of water in altering the energetics and structural properties of cryptomelane, an observation that has frequently been overlooked in previous studies.Water displaces potassium ions and initiates the formation of a homonuclear dimer ion (K2+) in the tunnels of hollandite. 相似文献
5.
Uplink scheduling in wireless systems is gaining importance due to arising uplink intensive data services (ftp, image uploads
etc.), which could be hampered by the currently in-built asymmetry in favor of the downlink. In this work, we propose and
study algorithms for efficient uplink packet-data scheduling in a CDMA cell. The algorithms attempt to maximize system throughput
under transmit power limitations on the mobiles assuming instantaneous knowledge of user queues and channels. However no channel
statistics or traffic characterization is necessary. Apart from increasing throughput, the algorithms also improve fairness
of service among users, hence reducing chances of buffer overflows for poorly located users.
The major observation arising from our analysis is that it is advantageous on the uplink to schedule “strong” users one-at-a-time,
and “weak” users in larger groups. This contrasts with the downlink where one-at-a-time transmission for all users has shown
to be the preferred mode in much previous work. Based on the optimal schedules, we propose less complex and more practical
approximate methods, both of which offer significant performance improvement compared to one-at-a-time transmission, and the
widely acclaimed Proportional Fair (PF) algorithm, in simulations. When queue content cannot be fed back, we propose a simple modification of PF, Uplink PF (UPF), that offers similar improvement.
Hereafter, we refer to users with low recieved power at the base even when transmitting at peak transmit power as “weak” users,
and the strongly recieved users at the base as “strong” users.
Krishnan Kumaran is currently a member of the Complex Systems Modeling section in the Corporate Strategic Research of ExxonMobil Corp., Clinton,
NJ. Formerly, he was a Member of Technical Staff in the Mathematics of Networks and Systems Research Department at Bell Labs
in Murray Hill, NJ, where his research interests were in modeling, analysis and simulation of design, resource management
and scheduling issues in telecommunication networks.
Lijun Qian is an assistant professor in the Department of Electrical Engineering at Prairie View A&M University. He received his B.S.
from Tsinghua University in Beijing, M.S. from Technion-Israel Institute of Technology, and Ph.D. from WINLAB, Rutgers University,
all in electrical engineering. Before joining PVAMU, he was a researcher at Networks and Systems Research Department of Bell
Labs in Murray Hill, NJ. His major research interests are in wireless communications and networking technologies, especially
in radio resource management, protocol design, TCP/RLP optimization and MPLS traffic engineering. 相似文献
6.
随着各高校校园网络规模的不断扩大和各种应用的急剧增加,各种新的网络问题也在不断出现。Sniffer是网络管理员进行网络管理的有效工具,可以有效地对网络进行实时监控,及时发现网络中存在的各种问题。本文首先介绍了Sniffer的工作原理,其次给出了实现Sniffer功能的编程流程图,并用C语言给出了编程所需的关键代码。 相似文献
7.
本文对采用区内C/I平衡的多区蜂窝CDMA系统下行链路的性能进行分析,给出两种区内C/I平衡算法并比较它们的性能,考虑呈对数正态分布的阴影和R^-4规律的路径损失的综合影响,采用与传统不同的小区平均中断概率来评价系统的性能。 相似文献
8.
In-time motion adjustment in laser cladding manufacturing process for improving dimensional accuracy and surface finish of the formed part 总被引:2,自引:0,他引:2
This paper presents in-time motion adjustment in laser cladding manufacturing process as a means to improve dimensional accuracy and surface finish of the built part. Defects occurring during laser cladding degrade the part quality such as dimensional accuracy and surface finish. In this paper, in-time motion adjustment strategy was presented to remedy and eliminate defects occurring during laser cladding to improve the dimensional accuracy and surface finish. Based on the relationship between the motion of laser head relative to the growing part and other parameters in effects on clad profile, the laser traverse speed, stand-off distance and laser approach orientation to the existing clad layer were adjusted by instructions from a close-loop control system in real time to remedy and eliminate defects. The results of the experiments verified the effects of in-time motion adjustment on dimensional accuracy and surface finish. 相似文献
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脂肪乳剂Intralipid代谢产物的高效液相色谱测定 总被引:2,自引:0,他引:2
本文介绍了利用HPLC色谱柱前衍生化技术简便,正确和灵敏地测定血清中游离脂肪酸的方法。在最佳条件下,一些脂肪酸的最低检知量为0.04μg。方法已用于脂肪乳剂Intralipid在诱发急性坏死性胰腺炎动物体内代谢产物测定。 相似文献