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cis-10-Chloro-N-methyl-decahydro-isoquinoline ( 5 ) and its trans-isomer 6 undergo heterolytic fragmentation in 80% ethanol by different mechanisms. As predictable on stereo-chemical grounds the cis-isomer 5 reacts by the accelerated synchronous mechanism, the trans-isomer 6 , however, by the two-step carbonium ion mechanism. Synchronous fragmentation therefore dominates over the two-step process even when the latter would lead to a relatively stable tertiary carbonium ion. In both cases the more highly substituted and thermochemically more stable olefinic fragment 8 is formed. 相似文献
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Daniel Cardenas Anna Turyanskaya Mirjam Rauwolf Arash Panahifar David Cooper Gregory R. Wohl Christina Streli Peter Wobrauschek Ana Pejović-Milić 《X射线光谱测定》2020,49(3):424-433
Strontium-based medications, such as strontium ranelate, have been suggested to have therapeutic effects in patients with osteoporosis. Strontium salts available off-shelf in stores across North America are assumed to provide similar effects as strontium ranelate and thus should lead to similar distributions of elemental strontium incorporated in bone. The objective of this study was to compare the spatial distribution of strontium in animal bones following the administration of strontium ranelate and strontium citrate. Seventeen-week-old Sprague–Dawley rats were split into three groups over 10 weeks and given 625 mg/kg/day of strontium ranelate and 676 mg/kg/day of strontium citrate; the control group received no additional supplementary strontium. The humeri were collected from all animals, and strontium distribution was mapped using 2D micro-XRF and 3D dual energy K-edge subtraction (KES) imaging. 2D and 3D elemental mapping methods demonstrated that strontium delivered during treatment by both salts had the same spatial distribution. 3D elemental strontium maps of treated animal bones showed that strontium was largely observed in the trabecular regions under the epiphyseal (growth) plate. The thickness of the strontium layers in both the strontium ranelate and strontium citrate sample was not significantly different (p = .9201). 2D micro-XRF and 3D dual-energy KES images effectively elucidated the spatial distribution of elemental strontium in calcified tissue. These methods provide a novel approach to evaluating the potential efficacy of strontium supplements in the treatment of osteoporosis. 相似文献
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Christopher J. Wohl Marcus A. Belcher John W. Connell 《Applied Surface Science》2009,255(18):8135-8144
Topographically rich surfaces were generated by spray-coating organic solutions of a polyhedral oligomeric silsesquioxane, octakis(dimethylsilyloxy)silsesquioxane (POSS), on Kapton® HN films and exposing them to radio frequency generated oxygen plasma. Changes in both surface chemistry and topography were observed. High-resolution scanning electron microscopy indicated substantial modification of the POSS-coated polyimide surface topographies as a result of oxygen plasma exposure. Water contact angles varied from 104° for unexposed POSS-coated surfaces to ∼5° for samples exposed for 5 h. Modulation of the dispersive and polar contributions to the surface energy was determined using van Oss Good Chaudhury theory. Changes in surface energy are related to potential adhesive interactions with lunar dust simulant particles. 相似文献
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C. G. Wohl 《The European Physical Journal C - Particles and Fields》2000,15(1-4):799-800
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Wislicenus H. Förster F. Matthiessen Neumann B. Biernacki Wohl V. Richards P. A. E. 《Analytical and bioanalytical chemistry》1897,36(1):497-500
Analytical and Bioanalytical Chemistry - 相似文献
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J. Formanék J. E. Politis R. Geduldt Sidersky E. Wein A. Herzfeld Burkhard Bodenbender Scheller E. Parcus Striegler Pellet Delville Preuss Gerken Bruhns Volpert F. G. Wiechmann Dammüller Gantenberg R. Creydt Wohl Strohmer Cech Herles Lindet Courtonne Wolf 《Analytical and bioanalytical chemistry》1891,30(1):63-89
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