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1.
Peptidosulfonamides are an emerging group of peptidomimetics with a variety of applications in medicinal chemistry. We present a novel approach to the synthesis of peptidosulfonamides, and apply it to a series of new potential inhibitors of the bacterial peptidoglycan biosynthesis enzymes MurD and MurE. The synthesis was conducted via N-phthalimido β-aminoethanesulfonyl chlorides, which are new building blocks for the synthesis of peptidosulfonamides. In the most crucial step, sulfonic acids or their sodium salts were converted into the corresponding sulfonyl chlorides using an excess of either SOCl2 or SOCl2/DMF, and then coupled to the C-protected amino acid. None of the compounds significantly inhibited MurD, however, some inhibited MurE; one had an IC50 below 200 μM, which constitutes a promising starting point for further development. Molecular modelling simulations were performed on two analogues to investigate the absence of inhibitory activity of the sulfonamide compounds on MurD. 相似文献
2.
Tomazela DM Gozzo FC Mayer I Engelmann FM Araki K Toma HE Eberlin MN 《Journal of mass spectrometry : JMS》2004,39(10):1161-1167
Ten homologous or isomeric singly, doubly, triply and quadruply charged cationic macrocyclic complexes I-Va, bn+ (n = 1-4) formed by the coordination of [Ru(bipy)2Cl]+ to the pyridyl N-atoms of a series of meso-(phenyl)m-(meta or para-pyridyl)n-porphyrins (m + n = 4) were transferred to the gas phase and structurally characterized by electrospray ionization (ESI) mass (MS) and tandem mass (MS/MS) spectrometry. Previously known to be stable in solution and in the solid state, I-Va, bn+ are found to constitute also a new class of stable, long-lived multiply charged gas-phase ions with spatially separated charge sites. Increasing intramolecular electrostatic repulsion from Ia, b+ to IVa, b3+ facilitates in-source and tandem collision-induced dissociation (CID). However, for the quadruply charged ions Va, b4+, electrostatic repulsion is alleviated mainly by ion pairing with the CF3SO3- counterion forming the salt clusters [Va,b/CF3SO3]3+ and [Va,b/(CF3SO3)2]2+ with reduced charge states. Ion-pairing that yields [IVa,b/CF3SO3]2+ is also observed as a minor ESI process for the triply charged ions IVa, b3+. The gaseous ions I-Va, bn+ (n = 2, 3 or 4) dissociate by sequential 'charge partitioning' with the formation of two cationic fragments by the release of [Ru(bipy)2Cl]+. The meta (a) and para (b) isomers and the positional isomers II2+ and III2+ display nearly identical ESI-MS and ESI-MS/MS spectra. ESI-MS/MS of I-Va, bn+ shows that the Ru-py(P) is, intrinsically, the weakest bond since this bond breaks preferentially upon CID. 相似文献
3.
Izilda A. Bagatin Alexandre T. Cruz Henrique E. Toma Mário J. Politi Grégoire J. -F. Demets 《Journal of inclusion phenomena and macrocyclic chemistry》2005,52(3):189-193
This article reports the synthesis and the properties of 5,11,17,23-tetra(t-butyl)-25,27-bis-(ethoxy-1,8-naphthalimide)-26,28-hidroxy-calix[4]arene and the formation of an inclusion compound in organic medium. This functionalized calix[4]arene was conceived as the association of a potential host species with a good fluorophore for optical sensoring purposes. Calix[4]-NI as we will call it, maintains its ‘cone-pinched’ configuration and exhibits typical naphthalimide fluorescence bands in non-polar solvents. Its ability to interact with guest species via hydrogen bonding in its endo-hydrophilic cavity to form inclusion compounds was verified with absorption and fluorescence measurements using N-ethanol-1,8-naphthalimide as guest species, which was projected to fit exactly the host cavity and to interact with its naphthalimide π electrons. For this reason, it was possible to follow the formation of the inclusion compound with electronic spectroscopy. 相似文献
4.
MM. J. Duflos D. Letouz G. Queguiner P. Pastour 《Journal of heterocyclic chemistry》1973,10(6):1083-1084
This communication describes the synthesis of l-methyl-2,3-diformylpyrrole. This new compound is used to prepare a new heterocycle, l-methylcyclohepta[b]pyrrol-6-one and thus allows a new synthesis of l-methylpyrrolo[2,3-d]pyridazine. 相似文献
5.
A trinuclear bis(cyclohexanedioximate)(chloro)(nitrosyl)ruthenium(II) complex containing two (2,2-bipyridine)-copper(II) groups has been synthesized and its electronic and electrochemical properties investigated. According to ZINDO/S calculations, the electronic structure of the ruthenium(dioximate)(nitrosyl) moiety is strongly delocalized. The electrochemical behavior has been interpreted with the aid of spectroelectrochemical measurements. In the trinuclear complex, it has been shown that the copper(II) ions can promote the oxidation of the NO species generated electrochemically, and also mediate the redox reactions of the complex, under a dioxygen atmosphere. 相似文献
6.
José Roberto Caetano da RochaLúcio Angnes Mauro Bertotti Koiti ArakiHenrique Eisi Toma 《Analytica chimica acta》2002,452(1):23-28
The modification of a glassy carbon surface by coating with an electrostatically assembled film of tetraruthenated cobalt porphyrin/(meso-tetra(4-sulphonatephenyl)porphyrinate zinc(II) yields an indicator electrode that allows the determination of nitrite to be performed with a limit of detection of 0.1 μM in a flow injection configuration. The dynamic range extends up to 1000 μM and the repeatability of the measurements was evaluated to be 1.5% with a throughput of 50 samples per hour. The efficiency of the bilayered film to mediate the electron transfer allows the determinations to be performed at a less positive potential (+0.75 V) with enhanced sensitivity. The coating also prevents the surface poisoning and its stability is maintained over several weeks. The same detector was used for determination of nitrate after reduction to nitrite in a reductor column containing copperised cadmium. This method was used for the determination of nitrate and nitrite in mineral water, saliva and cured meats, the results being in agreement with certified values and those obtained by using recommended procedures. 相似文献
7.
Zusammenfassung Eine Reihe von Metallkomplexen des 2,5-Dibenzoyl-3,4-dihydroxy-selenophens wurden spektroskopisch untersucht. Das Verhalten des Wismutkomplexes und die Möglichkeiten einer spektrophotometrischen Wismutbestimmung auf diesem Wege wurden eingehend studiert.
Herrn Univ.-Prof. Dr.Hans Lieb zum 80. Geburtstag gewidmet. 相似文献
Summary A spectroscopic examination was made of a series of metal complexes of 2,5-dibenzoyl-3,4-dihydroxyselenophen. The behavior of the bismuth complex and the possibilities of a spectrophotometric method of determining bismuth in this manner were studied thoroughly.
Herrn Univ.-Prof. Dr.Hans Lieb zum 80. Geburtstag gewidmet. 相似文献
8.
Vera R. L. Constantino Luiz F. C. de Oliveira Paulo S. Santos Henrique E. Toma 《Transition Metal Chemistry》1994,19(1):103-107
Summary The synthesis, spectra and electrochemistry of [Ru(bipy)2-(picOH)]+ and -picO-[Ru(bipy)2]2
2+ (bipy = 2,2-bipyridine and picOH = 3-hydroxypicolinate ion) are described. The spectroscopic properties in the visible region are dominated by the intense Ru bipy chargetransfer transitions. In the binuclear complex, the two [Ru(bipy)2L]2+ moieties are nonequivalent, exhibiting E
1/2 = 0.69 and 1.20 V versus s.h.e. The partially oxidized species exhibits a weak intervalence transfer band at 1085 nm, and is consistent with a Robin-Day class II mixed valence complex. 相似文献
9.
Simple catalytic systems for cross-coupling reactions of acyl chlorides with arylboronic acids under microwave conditions were tested. Microwave irradiation facilitated the reaction course. Mild reaction conditions afford the symmetrical and unsymmetrical aryl ketones in reasonable to high yields within a short time. A wide range of substrates bearing an electron-donating or an electron-withdrawing substituent on aryl ring of acid chloride as well as on boronic acid were examined and high yields of ketones were produced. 相似文献
10.