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Sonnenschein RN Farias JJ Tenney K Mooberry SL Lobkovsky E Clardy J Crews P 《Organic letters》2004,6(5):779-782
A reinvestigation of Auletta sp. yielded the novel compound milnamide C (3) plus the known compounds milnamide A (1), milnamide B (hemiasterlin) (2), jasplakinolide (5), and geodiamolides A (6), D (7), E (8), and G (9). The isolation work was guided by cytoskeletal bioactivity data. Compounds 2 and 3 were shown to cause microtubule depolymerization, and 6-9 were shown to cause microfilament disruption. This biological activity and the structural elucidation of 3, including X-ray analysis, are reported here. [structure: see text] 相似文献
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Thale Z Johnson T Tenney K Wenzel PJ Lobkovsky E Clardy J Media J Pietraszkiewicz H Valeriote FA Crews P 《The Journal of organic chemistry》2002,67(26):9384-9391
A reinvestigation of sponge natural products from additional Indo-Pacific collections of Xestospongiacf. carbonaria and X. cf. exigua has provided further insights on the structures, biological activities, and biosynthetic origin of bisannulated acridines. These alkaloids include one known pyridoacridine, neoamphimedine (2), and three new analogues, 5-methoxyneoamphimedine (4), neoamphimedine Y (5), and neoamphimedine Z (6). A completely new acridine, alpkinidine (7), was also isolated. A disk diffusion soft agar assay, using a panel of five cancer cell lines (solid tumors and leukemias) and two normal cells, was used to evaluate the differential cytotoxicity (solid tumor selectivity) of the sponge semipure extracts and selected compounds including amphimedine (1), 2, 4, and 7. While all four compounds were solid tumor selective, 1 and 2 were the most potent and 4 was the most selective. The rationale used to characterize the new structures is outlined along with the related biosynthetic pathways envisioned to generate 2 and 7. 相似文献
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Techniques were developed for high-sensitivity moiré interferometry by reflection, using a real reference grating of 1200 lines/mm (30,000 /in.). Coefficients of thermal expansion of selected graphite-epoxy laminates were determined in the temperature range of 297 K (75°F) to 422 K (300°F). Very good precision was achieved for a wide range of thermal-expansion coefficients, from approximately zero to 27 /K.D.E. Bowles was a Graduate Student at Virginia Polytechnic Institute and State University when this research was conducted; is currently Materials Engineer at NASA-Langley Research Center, Hampton, VA 23665Paper was presented at 1981 SESA Spring Meeting held in Dearborn, MI on May 31–June 4. 相似文献
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Tenney F. H. 《IEEE transactions on plasma science. IEEE Nuclear and Plasma Sciences Society》1976,4(3):157-161
The physics of two-energy-component toroidal plasmas (TCT) is reviewed. Energy "breakeven" using the TCT mode (deuteron beams on a triton-target plasma) can be attained at much smaller n? and temperature than in thermal plasma operation. This result reflects the fact that the fusion power density in a TCT can be much larger than in a thermal DT plasma of the same pressure. The large fusion power density (i. e., large neutron flux) of a TCT may find practical use in a number of applications. 相似文献
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White KN Amagata T Oliver AG Tenney K Wenzel PJ Crews P 《The Journal of organic chemistry》2008,73(22):8719-8722
Our 2004 disclosure of the amino hemiketal-containing spiroleucettadine was met with keen interest by the natural products and synthetic communities. As repeated efforts to synthesize spiroleucettadine failed and questions regarding the original structure elucidation process arose, evidence mounted against the validity of the proposed structure. The low ratio of H/C in the core of spiroleucattadine complicated the original structure elucidation process. Speculation prompted a reisolation of spiroleucettadine from an untouched portion of the original Luecetta collection and a thorough analysis of analytical data. In addition, a systematic analysis of candidate structures was performed via density functional theory (DFT) calculations; a favored high scoring structure 1b was ultimately confirmed to be spiroleucettadine via X-ray analysis of crystalline spiroleucettadine and reinforced the validity of DFT calculations in structure elucidation. We present the revised structure of spiroleucettadine, a bicyclic sponge alkaloid with a scarcity of H-atoms in its core. 相似文献
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Huawei Zhang Steven T. Loveridge Karen Tenney Phillip Crews 《Natural product research》2016,30(11):1262-1265
A new alkaloid, 3-dodecyl pyridine containing a terminal cyano group (1), was isolated from the methanol extract of an Indonesia marine sponge Haliclona sp. Its chemical structure was determined by a combination of spectroscopic methods, including 1D and 2D NMR. Bioassay results indicated that compound 1 had moderate cytotoxity against tumour cell lines A549, MCF-7 and Hela with IC50 values of 41.8, 48.4 and 33.2 μM, respectively. 相似文献
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Amagata T Amagata A Tenney K Valeriote FA Lobkovsky E Clardy J Crews P 《Organic letters》2003,5(23):4393-4396
[structure: see text] Structurally unique steroids, isocyclocitrinol A (1) and 22-acetylisocyclocitrinol A (2), were isolated from the extract of a saltwater culture of sponge-derived Penicilliun citrinum. The structures were established by analysis of 1D and 2D NMR data. The absolute structures were determined on the basis of X-ray structure analysis and application of modified Mosher's method. Furthermore, the structure of cyclocitrinol (3a) previously isolated from a terrestrial P. citrinum was revised as 3b. Compounds 1 and 2 showed weak antibacterial activity against Staphylococcus epidermidis and Enterococcus durans. 相似文献
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