Creation of a monopole in a spinor condensate

We propose a method to create a monopole structure in a multicomponent condensate by applying the basic methods used to create vortices and solitons experimentally in single-component condensates. We also show that by using a two-component structure for a monopole, we can avoid many problems related to the previously suggested three-component monopole. We discuss the observation and dynamics of such a monopole structure, and note that the dynamics of the two-component monopole differs from the dynamics of the three-component monopole.     

Shortcut to a Fermi-degenerate gas of molecules via cooperative association

We theoretically examine the creation of a Fermi-degenerate gas of molecules by considering a photoassociation or Feshbach resonance applied to a degenerate Bose-Fermi mixture of atoms. This problem raises interest because, unlike bosons, fermions in general do not behave cooperatively, so that the collective conversion of a degenerate gas atoms into a macroscopic number of diatomic molecules is not to be expected. Nevertheless, we find that the coupled Fermi system displays collective Rabi-like oscillations and a rapid adiabatic passage between atoms and molecules, thereby mimicking Bose-Einstein statistics. Cooperative association of a degenerate mixture of Bose and Fermi gases could therefore serve as a shortcut to a degenerate gas of Fermi molecules.     

Inert States of spin-S systems

We present a simple but efficient geometrical method for determining the inert states of spin-S systems. It can be used if the system is described by a spin vector of a spin-S particle and its energy is invariant in spin rotations and phase changes. Our method is applicable to an arbitrary S and it is based on the representation of a pure spin state of a spin-S particle in terms of 2S points on the surface of a sphere. We use this method to find candidates for some of the ground states of spinor Bose-Einstein condensates.     

Atypical perceptual narrowing in prematurely born infants is associated with compromised language acquisition at 2 years of age

Background

Protein aggregation plays important roles in several neurodegenerative disorders. For instance, insoluble aggregates of phosphorylated tau and of Aβ peptides are cornerstones in the pathology of Alzheimer's disease. Soluble protein aggregates are therefore potential diagnostic and prognostic biomarkers for their cognate disorders. Detection of the aggregated species requires sensitive tools that efficiently discriminate them from monomers of the same proteins. Here we have established a proximity ligation assay (PLA) for specific and sensitive detection of Aβ protofibrils via simultaneous recognition of three identical determinants present in the aggregates. PLA is a versatile technology in which the requirement for multiple target recognitions is combined with the ability to translate signals from detected target molecules to amplifiable DNA strands, providing very high specificity and sensitivity.

Results

For specific detection of Aβ protofibrils we have used a monoclonal antibody, mAb158, selective for Aβ protofibrils in a modified PLA, where the same monoclonal antibody was used for the three classes of affinity reagents required in the assay. These reagents were used for detection of soluble Aβ aggregates in solid-phase reactions, allowing detection of just 0.1 pg/ml Aβ protofibrils, and with a dynamic range greater than six orders of magnitude. Compared to a sandwich ELISA setup of the same antibody the PLA increases the sensitivity of the Aβ protofibril detection by up to 25-fold. The assay was used to measure soluble Aβ aggregates in brain homogenates from mice transgenic for a human allele predisposing to Aβ aggregation.

Conclusions

The proximity ligation assay is a versatile analytical technology for proteins, which can provide highly sensitive and specific detection of Aβ aggregates - and by implication other protein aggregates of relevance in Alzheimer's disease and other neurodegenerative disorders.     

Zeno and anti-Zeno effects for quantum Brownian motion

In this Letter, we investigate the occurrence of the Zeno and anti-Zeno effects for quantum Brownian motion. We single out the parameters of both the system and the reservoir governing the crossover between Zeno and anti-Zeno dynamics. We demonstrate that, for high reservoir temperatures, the short time behavior of environment induced decoherence is ultimately responsible for the occurrence of either the Zeno or the anti-Zeno effect. Finally, we suggest a way to manipulate the decay rate of the system and to observe a controlled continuous passage from decay suppression to decay acceleration using engineered reservoirs in the trapped ion context.     

Non-Markovian quantum jumps

Open quantum systems that interact with structured reservoirs exhibit non-Markovian dynamics. We present a quantum jump method for treating the dynamics of such systems. This approach is a generalization of the standard Monte Carlo wave function (MCWF) method for Markovian dynamics. The MCWF method identifies decay rates with jump probabilities and fails for non-Markovian systems where the time-dependent rates become temporarily negative. Our non-Markovian quantum jump approach circumvents this problem and provides an efficient unraveling of the ensemble dynamics.     

A bibliometric analysis of the development of next generation active nanotechnologies

Delineating the emergence of nanotechnologies that offer new functionalities is an important element in an anticipatory approach to the governance of nanotechnology and its potential impacts. This paper examines the transition to next generation active nanotechnologies which incorporate functions that respond to the environment or systems concepts that combine devices and structures that are dynamic and which may change their states in use. We develop an approach to identifying these active nanotechnologies and then use bibliometric analysis to examine the extent of research papers and patents involving these concepts. We also examine references to environmental, health, and safety concepts in these papers, given that these next generation nanotechnologies are likely to have risk profiles that are different from those of first-generation passive nanomaterials. Our results show a steady growth overall in focus on active nanotechnologies in the research literature and in patents over the study period of 1990–2010. We also find an increase in consideration given to environmental, health, and safety topics. While gaps are highlighted in our understanding of research and innovation in active nanotechnologies, the results suggest that there is beginning to be a shift to active nanotechnologies, with the implication that governance processes need to be conscious of this shift and to prepare for it.     

Cold collisions in strong laser fields: partial wave analysis of magnesium collisions

We have developed Monte Carlo wave function simulation schemes to study cold collisions between magnesium atoms in a strong red-detuned laser field. In order to address the strong-field problem, we extend the Monte Carlo wave function framework to include the partial wave structure of the three-dimensional system. The average heating rate due to radiative collisions is calculated with two different simulation schemes which are described in detail. We show that the results of the two methods agree and give estimates for the radiative collision heating rate for ²⁴Mg atoms in a magneto-optical trap based on the ¹S₀–¹P₁ atomic laser cooling transition.