Steroids and sexual hormones. Synthetic experiments in the limonin series lV. A new Westphalen-Lettré rearrangement in the 4,4-dimethyl-steroid series]

Applying the HgCl₂/ClCH₂SCH₃-reaction 1. to 4,4-dimethyl-Δ⁵-7-oxo-19-hydroxy-androstene (9) one observes an intramolecular rearrangement of the «Westphalen-Lettré»-type (→11). A related rearrangement is observed by treating 3-oxo-4,4-dimethyl-17β-acetoxy-Δ⁵-androstene (12) with HgCl₂/ClCH₂SCH₃-reagent (→13). Reaction of 3β, 17β-diacetoxy-4,4-dimethyl-19-(methoxymethyl)-Δ⁵-androstene (7) with hydrogenfluoride/urea-reagent gives rise to a similar rearranged product (→15).     

Zur Biosynthese des Strychnins. 135. Mitteilung über Alkaloide

From the feeding of young plants of Strychnos nux-vomica with [¹⁴C]-1-and [¹⁴C]-2-acetate it could be deduced that the C-atoms 22 and 23 were derived from acetate. [¹⁴C]-2-mevalonate, [¹⁴C]-2-geraniol and [¹⁴C]-2-geranyl pyrophosphate were also incorporated into strychnine. The distribution of radioactivity in the «mevalonate-strychnine» was in agreement with the monoterpenoid hypothesis. Feeding experiments especially with [¹⁴C]-tryptophane showed that the main production centre of the alkaloid lay in the roots and that only a small part of it was carried to the leaves. Tritium labelled WIELAND GUMLICH aldehyde as well as N_(a)-[¹⁴C]-1-acetyl WIELAND GUMLICH aldehyde were not converted into strychnine by S. nux-vomica.     

Limit on right handed weak coupling parameters from inelastic neutrino interactions

Right handed weak quark currents coupled to the usual left handed weak lepton current would be seen in inclusive antineutrino scattering on nuclei as a contribution at largey with the quark (not antiquark) structure function. We do not see such a term, and can therefore put an upper limit on the relative strengths of such right handed currents: \(\varrho ^2 = \frac{{\sigma _R }}{{\sigma _L }}< 0.009\) , 90% confidence. This measurement puts limits on the mixing angle of left-right symmetric models. In distinction to similar limits derived from muon decay or β decay, our limits are also valid if the right handed neutrino is heavy.     

Investigation of like-sign dimuon production in neutrino and antineutrino reactions

290 events of the type νFe→μ^?μ^?X and 53 events from the reaction $\text{ν}\text{Fe→μ}{}^{\mathrm{+}}\text{μ}{}^{\mathrm{+}}\text{X with}\text{E}{}_{\mathrm{\nu }}\text{>30}\text{GeV}$ and muon momenta p_μ>6.5GeV/c have been observed in the CDHS detector. After subtracting the background from charged-current processes with one π or K meson of the hadronic shower decaying into $\text{μ}{}^{\mathrm{?}}\text{ν}\text{(or μ}{}^{\mathrm{+}}\text{μ)}$, we obtain for neutrinos a rate of prompt like- sign dimuon production of (3.4±1.8)×10^?5 relative to the rate of charged-current events with the same cuts, or (4.1 ± 2.2)% relative to the prompt μ^?μ⁺ rate, and for antineutrinos the corresponding relative rates (4.3±2.3)×10^?5 and (4.2 ± 2.3)%. A possible explanation for the events is charm pair production at a level of 10^?3 relative to all charged-current reactions.     

Drag reduction in spatially developing turbulent boundary layers by spatially intermittent blowing at constant mass-flux

A series of large-eddy simulations of spatially developing turbulent boundary layers with uniform blowing at moderate Reynolds numbers (based on free-stream velocity, U_∞, and momentum thickness, θ) up to Re_θ ≈ 2500 were performed with the special focus on the effect of intermittent (separated in streamwise direction) blowing sections. The number of blowing sections, N, investigated is set to be 3, 6, 20, 30 and compared to N = 1, which constitutes the reference case, while the total wall-mass flux is constrained to be the same for all considered cases, corresponding to a blowing amplitude of 0.1% of U_∞ for the reference case. Results indicate that the reference case provides a net-energy saving rate of around 18%, which initially decreases at most 2% points for N = 3 but recovers with increasing N, where the initial reduction of the drag reduction is found to be related to the shorter streamwise length of the intermittent blowing sections. The physical decomposition of the skin friction drag through the Fukagata-Iwamoto-Kasagi (FIK) identity shows that the distribution of all components over each blowing section has similar trends, resulting in similar averaged values over the whole control region.     

A vorticity stretching diagnostic for turbulent and transitional flows

Vorticity stretching in wall-bounded turbulent and transitional flows has been investigated by means of a new diagnostic measure, denoted by Γ, designed to pick up regions with large amounts of vorticity stretching. It is based on the maximum vorticity stretching component in every spatial point, thus yielding a three-dimensional scalar field. The measure was applied in four different flows with increasing complexity: (a) the near-wall cycle in an asymptotic suction boundary layer (ASBL), (b) K-type transition in a plane channel flow, (c) fully turbulent channel flow at Re _τ = 180 and (d) a complex turbulent three-dimensional separated flow. Instantaneous data show that the coherent structures associated with intense vorticity stretching in all four cases have the shape of flat ‘pancake’ structures in the vicinity of high-speed streaks, here denoted ‘h-type’ events. The other event found is of ‘l-type’, present on top of an unstable low-speed streak. These events (l-type) are further thought to be associated with the exponential growth of streamwise vorticity in the turbulent near-wall cycle. It was found that the largest occurrence of vorticity stretching in the fully turbulent wall-bounded flows is present at a wall-normal distance of y ⁺?=?6.5, i.e. in the transition between the viscous sublayer and buffer layer. The associated structures have a streamwise length of ~200–300 wall units. In K-type transition, the Γ-measure accurately locates the regions of interest, in particular the formation of high-speed streaks near the wall (h-type) and the appearance of the hairpin vortex (l-type). In the turbulent separated flow, the structures containing large amounts of vorticity stretching increase in size and magnitude in the shear layer upstream of the separation bubble but vanish in the backflow region itself. Overall, the measure proved to be useful in showing growing instabilities before they develop into structures, highlighting the mechanisms creating high shear region on a wall and showing turbulence creation associated with instantaneous separations.     

On the incorporation of geraniol and farnesol into cantharidin (author's transl)

On the incorporation of geraniol and farnesol into cantharidin Earlier investigations [1] have shown that cantharidin (1) is biosynthesized by the male Lytta vesicatoria L. (Meloidae, Coleoptera) from the common terpenoid precursors mevalonate and farnesol (3) . To prove if geraniol (2) is incorporated via farnesol (3) into cantharidin (1) the following geraniols have been synthesized and injected into either larvae or male adult Lytta vesicatoria, partly in a mixture with synthetic 11′, 12-[³H]-farnesol as an internal standard: 2-[¹⁴C]-, 7-[¹⁴C]-, 7′, 8-[¹⁴C]-, 7′, 8-[³H]-geraniol. Unexpectedly, geraniol (2) was not specifically incorporated into cantharidin (1) perhaps due to its higher toxicity or its faster degradation relative to the other precursors before incorporation. The incorporation of U-[¹⁴C]-leucine, U-[¹⁴C]-isoleucine and 1-[¹⁴C]-glucose into cantharidin (1) via their metabolites is evident by degradation studies, whereas 1-[¹⁴C]- and 2-[¹⁴C]-glycine do not serve as precursors for cantharidin (1) .