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排序方式: 共有160条查询结果,搜索用时 62 毫秒
1.
Kevin Phelps 《Designs, Codes and Cryptography》2015,77(2-3):357-363
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Phelps T. J. Siegrist R. L. Korte N. E. Pickering D. A. Strong-Gunderson J. M. Palumbo A. V. Walker J. F. Morrissey C. M. Mackowski R. 《Applied biochemistry and biotechnology》1994,45(1):835-845
Applied Biochemistry and Biotechnology - Soil column studies were used to evaluate petroleum hydrocarbon (PHC) remediation in soils from Kwajalein Atoll. Treatments included controls, and... 相似文献
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Palumbo A. V. Scarborough S. P. Pfiffner S. M. Phelps T. J. 《Applied biochemistry and biotechnology》1995,51(1):635-647
Applied Biochemistry and Biotechnology - The US Department of Energy, Office of Technology Development, has supported a field-scalein situ demonstration of trichloroethylene (TCE) bioremediation at... 相似文献
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Blinov BB Chu CM Courant ED Crandell DA Kaufman WA Krisch A Nurushev TS Phelps RA Raczkowski DB Ratner LG Wong VK Caussyn DD Derbenev YS Ellison TJ Lee SY Rinckel T Schwandt P Sperisen F Stephenson EJ von Przewoski B Baiod R Minty MG Ohmori C Wienands U 《Physical review letters》1994,73(12):1621-1623
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Rosenstein BS Phelps RG Weinstock MA Bernstein JL Gordon ML Rudikoff D Kantor I Shelton R Lebwohl MG 《Photochemistry and photobiology》1999,70(5):798-806
Sun exposure histories were obtained from a series of patients age 35 or younger following diagnosis and removal of a basal cell carcinoma (BCC). The DNA was extracted from tumor biopsy samples derived from BCC of 10 patients who reported that they did not use sunscreens during youth (age 18 or younger) and 10 patients who routinely employed sunscreens during this age period. Exons 5-9 of the p53 gene were then amplified in three fragments from these samples using a nested polymerase chain reaction (PCR) approach and screened for mutations using an RNA heteroduplex assay. All PCR products displaying evidence of a mutation were sequenced. It was found that 6 of the 10 patients who were not routine sunscreen users displayed mutations in these p53 exons. All of the mutations were located at dipyrimidine sites, five of the six were C-->T transitions and one mutation was a tandem double mutation, consistent with a role for solar UVB in BCC formation. In contrast, only one p53 mutation was detected in the group of 10 patients who routinely employed sunscreens during childhood and adolescence. Hence, a significantly (P = 0.029) lower level of p53 mutations was detected in the BCC obtained from sunscreen users compared with tumors derived from nonusers. These findings suggest that the mechanisms involved in the etiology of skin carcinogenesis differ in sunscreen users compared with people who did not routinely employ sunscreens. These data are also indicative of a protective effect associated with sunscreen use against the formation of p53 mutations. It is possible that the patients who were diagnosed with BCC despite their use of sunscreens possessed a genetic susceptibility for skin cancer formation and developed BCC through a p53-independent pathway. Alternatively, solar UVA wavelengths, that were generally not blocked by the suncare products employed by the sunscreen users, may have played a significant role in BCC development through induction of a mutation(s) in an oncogene and/or a tumor suppressor gene, other than p53, for these patients. 相似文献
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Charles J. Colbourn Dean G. Hoffman Kevin T. Phelps Vojtěch Rödl Peter M. Winkler 《Combinatorica》1991,11(3):207-218
We prove that the number oft-wise balanced designs of ordern is asymptotically
, provided that blocks of sizet are permitted. In the process, we prove that the number oft-profiles (multisets of block sizes) is bounded below by
and above by
for constants c2>c1>0. 相似文献
8.
Alicia M. Phelps Nicholas S. Dolan Nathan T. Connell Jennifer M. Schomaker 《Tetrahedron》2013,69(27-28):5614-5621
A versatile intramolecular reaction of allene-containing diazomalonates that exhibits excellent chemoselectivity for either allenic C–H insertion or cyclopropanation is demonstrated. The identity of the product depends on the transition metal catalyst that is employed for the reaction. Rh catalysts promote exclusive C–H insertion with good diastereoselectivity for the trans product, while Cu catalysis enables intramolecular cyclopropanation to yield methylenecyclopropanes with moderate to good E:Z ratios. 相似文献
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