Summary of the CMS potential for the Higgs boson discovery

The European Physical Journal C - This work summarizes the studies for the Higgs boson searches in CMS at the LHC collider. The main discovery channels are presented and the potential is given for...     

Search for heavy neutral MSSM Higgs bosons with CMS: reach and Higgs mass precision

The search for MSSM Higgs bosons will be an important goal at the LHC. We analyze the search reach of the CMS experiment for the heavy neutral MSSM Higgs bosons with an integrated luminosity of 30 or 60 fb^-1. This is done by combining the latest results for the CMS experimental sensitivities based on full simulation studies with state-of-the-art theoretical predictions of the MSSM Higgs-boson properties. The results are interpreted in MSSM benchmark scenarios in terms of the parameters tan β and the Higgs-boson mass scale, M_A. We study the dependence of the 5σ discovery contours in the M_A–tan β plane on variations of the other supersymmetric parameters. The largest effects arise from a change in the higgsino mass parameter μ, which enters both via higher-order radiative corrections and via the kinematics of Higgs decays into supersymmetric particles. While the variation of μ can shift the prospective discovery reach (and correspondingly the ”LHC wedge” region) by about Δtan β=10, we find that the discovery reach is rather stable with respect to the impact of other supersymmetric parameters. Within the discovery region we analyze the accuracy with which the masses of the heavy neutral Higgs bosons can be determined. We find that an accuracy of 1–4% should be achievable, which could make it possible in favorable regions of the MSSM parameter space to experimentally resolve the signals of the two heavy MSSM Higgs bosons at the LHC.     

Evaluation of 3- and 4-Phenoxybenzamides as Selective Inhibitors of the Mono-ADP-Ribosyltransferase PARP10

Intracellular ADP-ribosyltransferases catalyze mono- and poly-ADP-ribosylation and affect a broad range of biological processes. The mono-ADP-ribosyltransferase PARP10 is involved in signaling and DNA repair. Previous studies identified OUL35 as a selective, cell permeable inhibitor of PARP10. We have further explored the chemical space of OUL35 by synthesizing and investigating structurally related analogs. Key synthetic steps were metal-catalyzed cross-couplings and functional group modifications. We identified 4-(4-cyanophenoxy)benzamide and 3-(4-carbamoylphenoxy)benzamide as PARP10 inhibitors with distinct selectivities. Both compounds were cell permeable and interfered with PARP10 toxicity. Moreover, both revealed some inhibition of PARP2 but not PARP1, unlike clinically used PARP inhibitors, which typically inhibit both enzymes. Using crystallography and molecular modeling the binding of the compounds to different ADP-ribosyltransferases was explored regarding selectivity. Together, these studies define additional compounds that interfere with PARP10 function and thus expand our repertoire of inhibitors to further optimize selectivity and potency.     

Search for Higgs bosons in SUSY cascades in CMS and dark matter with non-universal gaugino masses

In grand-unified theories (GUT), non-universal boundary conditions for the gaugino masses may arise at the unification scale and may affect the observability of the neutral MSSM Higgs bosons (h/H/A) at the LHC. The implications of such non-universal gaugino masses are investigated for Higgs boson production in the SUSY cascade decay chain , , , produced in pp interactions. In the singlet representation with universal gaugino masses only the light Higgs boson can be produced in this cascade with the parameter region of interest for us, while with non-universal gaugino masses heavy neutral MSSM Higgs boson production may dominate. The allowed parameter space in the light of the WMAP constraints on the cold dark-matter relic density is investigated in the above scenarios for gaugino mass parameters. We also demonstrate that combination of representations can give the required amount of dark matter in any point of the parameter space. In the non-universal case we show that heavy Higgs bosons can be detected in the cascade studied in parameter regions with the WMAP preferred neutralino relic density.     

Safety aspects of gadofosveset in clinical practice – analysis of acute and long-term complications

Purpose

The purpose of this retrospective study was to systematically search for acute adverse reactions and long-term complications in all patients that had been administered gadofosveset at our hospital.

Materials and methods

We identified 67 gadofosveset administrations during 2006–2009 in 62 patients from 8 to 84 years of age. Radiological information system (RIS) and clinical patient records were analyzed for suspected acute adverse reactions and long-term complications including nephrogenic systemic fibrosis (NSF).The gadofosveset doses ranged between 0.024 and 0.060 mmol/kg bodyweight with a mean dose of 0.031-mmol/kg bodyweight. Follow-up time of the patients ranged from less than 1 year up to 4 years with a mean follow-up time of 2.1 years.

Results

No acute adverse events or technical failures related to the contrast medium were recorded in the RIS. No dermatological and nephrological diseases related to the gadofosveset administration were found in the clinical patient records. Four patients died during follow-up without any apparent relation to the gadofosveset exposure.

Conclusions

Based on our clinical material we conclude that gadofosveset is safe for a mixed patient population with no acute adverse events or any indications of long-term complications during the follow-up time up to four years.     

Low temperature plasma assisted atomic layer deposition in nitrogen carrier gas studied by optical emission spectroscopy

A low temperature plasma assisted atomic layer deposition process from tetrakis (dimethylamino)-titanium (TDMAT) and oxygen plasma was investigated using optical emission spectroscopy in a commercial TFS-500 atomic layer deposition reactor in industrial-like conditions with different plasma powers to optimize the plasma-assisted deposition process and to develop a tool for process control. The major emitting species recognized were the nitrogen first followed by the second positive system, carbon monoxide, nitrogen monoxide (γ)-system, atomic carbon and atomic nitrogen. The process measurements were compared to background measurements to see the process induced differences. CH _x appearance in the plasma lowered the intensities of CO, NO and N₂ 1st⁺ system peaks. Also, the nitrogen atom content varied in the process measurements. By monitoring the affected species and vibrational temperature, the effect of TDMAT oxidation on the surface could be seen through the resulting changes in the plasma emission.