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1.
Sunil B. Jadhav 《Tetrahedron letters》2007,48(14):2485-2487
A rapid, mild and high yielding method for the synthesis of methylthiomethyl esters is reported from the corresponding aliphatic, aromatic and unsaturated carboxylic acids under Swern oxidation conditions using dimethylsulfoxide, oxalyl chloride and triethylamine at low temperature. 相似文献
2.
A rapid reversed-phase high-performance liquid chromatographic procedure is developed and validated for the resolution of
the cis-isomer of 1-[[p-[2-(3-ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido) ethyl] phenyl] sulfonyl]-3-(trans-4-methylcyclohexyl) urea, a dopamine agonist in bulk drugs. The cis-isomer and glimepiride were baseline resolved on a Waters Symmetry column (50 × 4.6 mm, 3.5 μm) using a mobile phase system
containing water: tetrahydrofuran (75:25; v/v. The chromatographic resolutions between cis-isomer and glimepiride were found to be greater than two. The developed method was extensively validated and proved to be
robust. The limit of detection and the limit of quantification of cis-isomer were 500 and 1,500 ng mL−1, respectively, for 10 μL injection volume. The percentage recovery of the cis-isomer ranged from 97.3 to 102.0 in bulk drug samples of glimepiride. Glimepiride sample solution and mobile phase were found
to be stable for at least 48 h. The proposed method was found to be suitable and accurate for the quantitative determination
of the cis-isomer in bulk drugs. 相似文献
3.
Chromium has been determined in environmental samples. The method described here involves the irradiation of environmental samples and a g quantity of standard with thermal neutrons at the self-serve position in the CIRUS reactor, followed by dissolution of the sample and standard in the presence of a milligram amount of carrier. Both the sample and the standard are subjected to substoichiometric extraction under controlled experimental conditions with alizarin into cyclohexane. An aliquot of the organic phase was counted on a gamma-ray spectrometer. The concentration of Cr in water samples from Bombay and Karad City, and the accuracy, precision and sensitivity of the method are discussed. 相似文献
4.
Asymmetric hydroboration of appropriate alkenes with diisopinocampheylborane (Ipc2BH) or monoisopinocampheylborane (IpcBH2) produces intermediates that readily eliminate α-pinene on treat- ment with acetaldehyde, providing a direct, convenient route to chiral boronic esters of high enantiomeric purities. Mixed chiral trialkylboranes, readily prepared by stepwise hydroboration of appropriate alkenes with IpcBH2, eliminate α-pinene on treatment with acetaldehyde under very mild conditions. The procedure makes readily available chiral borinic esters of high enantiomeric purities. The synthetic utility of chiral borinic esters is demonstrated by converting them into acyclic ketones including an alarm pheromone of the ant Monica mutica. 相似文献
5.
Kossen K Vaish NK Jadhav VR Pasko C Wang H Jenison R McSwiggen JA Polisky B Seiwert SD 《Chemistry & biology》2004,11(6):807-815
Many reports have suggested that target-activated ribozymes hold potential value as detection reagents. We show that a "half"-ribozyme ligase is activated similarly by three unstructured oligoribonucleotides representing the major sequence variants of a hepatitis C virus 5'-untranslated region (5'-UTR) target and by a structured RNA corresponding to the entire 5'-UTR. Half-ribozyme ligation product was detected both in an ELISA-like assay and in an optical immunoassay through the use of hapten-carrying substrate RNAs. Both assay formats afford a limit of detection of approximately 1 x 10(6) HCV molecules (1.6 attomol, 330 fM), a sensitivity which compares favorably to that provided by standard immunoassays. These data suggest that target-activated ribozyme systems are a viable approach for the sensitive detection of viral nucleic acids using high-throughput platforms. 相似文献
6.
K. V. Lohitakshan P. D. Mithapara P. S. Nair S. A. Pai K. Raghuraman A. V. Jadhav H. C. Jain 《Journal of Radioanalytical and Nuclear Chemistry》1994,183(2):359-370
Extraction of trivalent (Pu3+, Am3+, actinides and Eu3+, a representative of lanthanides) and tetravalent (Np4+ and Pu4+) actinides has been studied with dihexyl N,N-di-ethylcarbamoylmethyl phosphonate (DHDECMP) in combination with TBP in benzene from 2M nitric acid. The stoichiometries of the species extracted were found to be M(NO3)3·(3–n) TBP·n DHDECMP (for trivalent ions) and M(NO3)4·(2–n) TBP·n DHDECMP (for tetravalent ions) by the slope ratio method. The extraction constants evaluated (from the distribution data) indicate that for tetravalent ions (with solvation number two) the extraction constant increases when TBP (Kh=0.17) molecules are successively replaced by more basic DHDECMP (Kh=0.34) molecules. However, for trivalent ions (with solvation number three) when TBP molecules are totally replaced by DHDECMP molecules stereochemical factors appear and instead of increase, a substantial decrease in extraction constants is observed for Eu3+ and Am3+, a lesser decrease being observed for Pu3+ (larger ion). 相似文献
7.
An enantioselective high-performance liquid chromatographic method, with precolumn derivatization with Marfey’s chiral reagent,
sodium 2,4-dinitro-5-fluorophenyl-l-alanine amide, has been developed for resolution of the enantiomers of a new antiepileptic drug, pregabalin, in the bulk
drug. The diastereomers of the pregabalin enantiomers were resolved to baseline on a reversed-phase ODS column with a 60:40
(v/v) mixture of aqueous 0.2% triethylamine (pH adjusted to 3.5 with dilute orthophosphoric acid) and acetonitrile as mobile phase.
Resolution between the diastereomers was not less than five. The method was extensively validated and proved to be robust.
The calibration plot was indicative of an excellent linear relationship between response and concentration over the range
750 (LOQ) to 7,500 ng L−1 for the R enantiomer. The limits of detection and quantification of the R enantiomer were 250 and 750 ng L−1, respectively, for an injection volume of 10 μL. Recovery of the R enantiomer from bulk drug samples of pregabalin ranged from 97.5 to 101.76%. Solutions of pregabalin in water and in the
mobile phase were found to be stable for at least 48 h. The method was found to be suitable and accurate for quantitative
determination of the R enantiomer in the bulk drug. It can be also used to test the stability of samples of pregabalin. 相似文献
8.
J. Y. Jadhav J. Preston W. R. Krigbaum 《Journal of polymer science. Part A, Polymer chemistry》1989,27(4):1175-1195
Four 2,5-biphenylene based difunctional condensation monomers, such as 2,5-diphenyldicar-boxylic acid or phenylterephthalic acid (PTA), 2,5-bis(carbonylimino-4-benzoic acid)biphenyl (2,5-BCIBABP), 2,5-diaminobiphenyl hydrochloride (2,5-DABP.HCl) and 2,5-bis(iminocarbonyl-4-benzoic acid)biphenyl (2,5-BICBABP), have been synthesized and characterized. These monomers were polymerized in combination with terephthalic acid (TA) and p-phenylenediamine (PPD) via the phosphorylation reaction to prepare a series of phenyl-substituted random copolyamides having all amide groups attached to para-positions of the benzene rings. All the copolyamides have been characterized by solubility, solution viscosity, and by differential scanning calorimetry (DSC). Some of these copolyamides have unusual solubility in organic solvents such as N,N-dimethylacetamide (DMAc) and N-methyl-2-pyrrolidinone (NMP) containing dissolved lithium chloride. A few copolyamides were tested for lyotropic behavior and found to form anisotropic solutions at critical concentrations in organic solvents. A randomly distributed unsymmetrical phenyl substituent on the benzene ring of para-oriented wholly aromatic polyamides dramatically changes the solubility and melting point. The phenyl substituent on a terephthalic acid unit is more efficient in decreasing melting point and increasing solubility in organic solvents of aromatic polyamides than the one on a p-phenylenediamine unit. However, the former also introduces a more flexible link in the extended polyamide chain. 相似文献
9.
Trushant Lohar Sanjay Jadhav Arjun Kumbhar Ananda Mane Rajashri Salunkhe 《Research on Chemical Intermediates》2016,42(6):5329-5338
An environmentally benign, multicomponent integrated chemical process has been developed for the synthesis of 3,5-dispirosubstituted piperidines by cyclo-condensation reaction of amines, formaldehyde, and dimedone using iron(III) trifluroacetate [Fe(F3CCO2)3] Lewis acid in aqueous micellar medium at ambient temperature (25–30 °C). The heterogeneous solid acid catalyst conveniently promotes this double amino methylation reaction in which six molecules condense in one pot to form six new covalent bonds. The synthesized 3,5-dispirosubstituted piperidines have been screened for their in vitro antibacterial activity using agar well method. Many of these compounds showed satisfactory antibacterial activity as compared to standard drugs against all the bacteria tested. 相似文献
10.
Jagannath Jadhav Sharanabasappa Khanapure Rajashri Salunkhe Gajanan Rashinkar 《应用有机金属化学》2013,27(8):486-488
Zirconocene dichloride (Cp2ZrCl2) in the presence of DMF was found to be a highly efficient catalyst for the synthesis of structurally diverse 2‐substituted quinozolin‐4(3H)‐ones by reaction of anthranilimide with a wide range of aryl aldehydes. Copyright © 2013 John Wiley & Sons, Ltd. 相似文献