Omega- and Omega+ production in central Pb + Pb collisions at 40 and 158A GeV

Results are presented on Omega production in central Pb+Pb collisions at 40 and 158A GeV beam energy. For the first time in heavy ion reactions, rapidity distributions and total yields were measured for the sum Omega(-) + Omega(+) at 40A GeV and for Omega(-) and Omega(+) separately at 158A GeV. The yields are strongly underpredicted by the string-hadronic UrQMD model but agree better with predictions from hadron gas models.     

An inconsistency in the simulation of Bose-Einstein correlations

We show that the formalism commonly used to implement Bose-Einstein correlations in Monte-Carlo simulations can lead to values of the two-particle correlator significantly smaller than unity, in the case of sources with strong position-momentum correlations. This is more pronounced when the phase space of the emitted particles is strongly reduced by experimental acceptance or kinematic analysis selections. It is inconsistent with general principles from the coherent state formalism according to which the Bose-Einstein correlator is larger than unity. This inconsistency seems to be rooted in the fact that quantum mechanical localization properties are not taken into account properly. Received: 11 April 1997 / Revised version: 9 June 1997     

System-size dependence of strangeness production in nucleus-nucleus collisions at squareroot[sNN]=17.3 GeV

Emission of pi+/-, K+/-, phi, and Lambda was measured in near-central C+C and Si+Si collisions at 158 AGeV beam energy. Together with earlier data for p+p, S+S, and Pb+Pb, the system-size dependence of relative strangeness production in nucleus-nucleus collisions is obtained. Its fast rise and the saturation observed at about 60 participating nucleons can be understood as the onset of the formation of coherent systems of increasing size.     

Event-by-event fluctuations of the Kaon-to-Pion ratio in central Pb+Pb collisions at 158 GeV per nucleon

We present the first measurement of fluctuations from event to event in the production of strange particles in collisions of heavy nuclei. The ratio of charged kaons to charged pions is determined for individual central Pb+Pb collisions. After accounting for the fluctuations due to detector resolution and finite number statistics we derive an upper limit on genuine nonstatistical fluctuations, which could be related to a first- or second-order QCD phase transition. Such fluctuations are shown to be very small.     

Inclusive production of protons, anti-protons and neutrons in p+p collisions at 158 GeV/c beam momentum

New data on the production of protons, anti-protons and neutrons in p+p interactions are presented. The data come from a sample of 4.8 million inelastic events obtained with the NA49 detector at the CERN SPS at 158 GeV/c beam momentum. The charged baryons are identified by energy loss measurement in a large TPC tracking system. Neutrons are detected in a forward hadronic calorimeter. Inclusive invariant cross sections are obtained in intervals from 0 to 1.9 GeV/c (0 to 1.5 GeV/c) in transverse momentum and from ?0.05 to 0.95 (?0.05 to 0.4) in Feynman x for protons (anti-protons), respectively. p _T integrated neutron cross sections are given in the interval from 0.1 to 0.9 in Feynman x. The data are compared to a wide sample of existing results in the SPS and ISR energy ranges as well as to proton and neutron measurements from HERA and RHIC.     

Synthesis and endosomolytic properties of poly(amidoamine) block copolymers

The poly(amidoamine)s (PAAs) ISA 1 and ISA 23 display pH-dependent conformational change and pH-dependent membrane perturbation. These properties confer potential for use as endosomolytic polymers for intracytoplasmic delivery of toxins and genes. Both polymers are relatively non-toxic, and moreover ISA 23 has the beneficial property in vivo, of being non hepatotropic when administered intravenously. Although ISA 23 and ISA 1 demonstrate ability to transfect cells, ISA 1 is also able to promote intracellular delivery of non-permeant toxins. The aim of this study was to synthesise random and block copolymers of ISA 1 and ISA 23 and investigate whether these second generation hybrids would allow optimisation of PAA biological characteristics. Random and block copolymers of ISA 1 and ISA 23 were synthesised by hydrogen transfer polyaddition to generate a library of PAAs with an ISA 23:ISA 1 molar ratios of 2:1 to 4:1. The resultant polymers have a pI slightly below 7.4 and a M(w) of 19,900-49,000 g/mol and a M(n) of 13,100-24,100 g/mol. Whereas none of the random or block copolymers were haemolytic at pH 7.4 all demonstrated pH-dependent membrane activity. At pH 5.5 they caused 50-60% haemoglobin (Hb) release over 1 h. This was slightly less than that seen for ISA 23 (80% Hb release). None of the copolymers were cytotoxic against B16F10 cells during a 72 h incubation (IC(50) > 2 mg/ml; MTT assay). The ability of the random and block copolymer PAAs to deliver the toxin gelonin was also examined, but only ISA 1 and the block copolymer B2 (ISA 23:ISA 1 at a 2:1 molar ratio) were able to promote intracellular delivery, as measured by cytotoxic activity. It would be interesting to study the body distribution of B2 and determine whether this toxin-delivering PAA is able to escape liver capture.     

Evidence for an exotic S= -2, Q= -2 baryon resonance in proton-proton collisions at the CERN SPS

Results of resonance searches in the Xi(-)pi(-), Xi(-)pi(+), Xi;(+)pi(-), and Xi;(+)pi(+) invariant mass spectra in proton-proton collisions at sqrt[s]=17.2 GeV are presented. Evidence is shown for the existence of a narrow Xi(-)pi(-) baryon resonance with mass of 1.862+/-0.002 GeV/c(2) and width below the detector resolution of about 0.018 GeV/c(2). The significance is estimated to be above 4.2sigma. This state is a candidate for the hypothetical exotic Xi(--)(3/2) baryon with S=-2, I=3 / 2, and a quark content of (dsdsū). At the same mass, a peak is observed in the Xi(-)pi(+) spectrum which is a candidate for the Xi(0)(3/2) member of this isospin quartet with a quark content of (dsus[-]d). The corresponding antibaryon spectra also show enhancements at the same invariant mass.