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Cytotoxicity and Antiproliferative Effect of Hypericin and Derivatives after Photosensitization 总被引:3,自引:1,他引:3
Ann L. Vandenbogaerde Els M. Delaey Annelies M. Vantieghem Bernard E. Himpens Wilfried J. Merlevede Peter A. de Witte 《Photochemistry and photobiology》1998,67(1):119-125
The toxicity on three human tumor cell lines (A431, HeLa and MCF7) of five phenanthroperylenequinones (hypericin and derivatives) and two perylenequinones (cercosporin and calphostin C) was investigated after photosensitization (4 J/cm2 ). Furthermore, the antiproliferative effect on HeLa cells was studied for the phenanthroperylenequinones. Hypericin, 2,5-dibromohypericin, 2,5,9,12-tetrabromohypericin and perylenequinones displayed a potent cytotoxic and antiproliferative effect in the nanomolar range. Hypericin dicarboxylic acid exhibited no photoactivity. In general, the antiproliferative activity correlated well with the photocytotoxicity. However, the nonphotocytotoxic compound hexamethylhypericin showed potent antiproliferative activity in the nanomolar range, probably exerting its action by protein kinase C inhibition. Without light irradiation, no cytotoxic and antiproliferative effect was observed for any photocytotoxic phenanthroperylenequinone compound. Furthermore, confocal laser microscopy revealed that the subcellular localization in A431 cells was similar for the photoactive compounds; the photosensitizers were mainly concentrated in the perinuclear region, probably corresponding with the Golgi apparatus and the endoplasmic reticulum. In addition, the accumulation of the photosensitizers in HeLa cells was investigated. All compounds except hypericin dicarboxylic acid were found to concentrate to a large extent in the cells. The compound 2,5,9,12-tetrabromohypericin seemed intrinsically more effective than hypericin since the intracellular concentration of the bromoderivative was a magnitude of order lower than that of hypericin although both compounds showed similar photobiological activity. 相似文献
4.
Vallée RA Marsal P Braeken E Habuchi S De Schryver FC Van der Auweraer M Beljonne D Hofkens J 《Journal of the American Chemical Society》2005,127(34):12011-12020
Experimental (Single Molecule Spectroscopy) and theoretical (quantum-chemical calculations and Monte Carlo and molecular dynamics simulations) techniques are combined to investigate the behavior and dynamics of a polymer-dye molecule system. It is shown that the dye molecule of interest (1,1'-dioctadecyl-3,3,3',3'-tetramethylindo-dicarbocyanine) adopts two classes of conformations, namely planar and nonplanar ones, when embedded in a poly(styrene) matrix. From an in-depth analysis of the fluorescence lifetime trajectories, the planar conformers can be further classified according to the way their alkyl side chains interact with the surrounding poly(styrene) chains. 相似文献
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Competition between languages or cultural traits diffusing in the same geographical area is studied combining the model of Abrams and Strogatz with a model of human dispersal on an inhomogeneous substrate. Also, the effect of population growth is discussed. It is shown through numerical simulations that the final configuration of the languages can be strongly affected by geographical and historical factors. These factors are not related to the dynamics of culture transmission, but rather to initial population distributions as well as geographical boundaries and inhomogeneities, which modulate the diffusion process. 相似文献
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The interaction between two paramagnetic metal centers, a [3Fe-4S](+) cluster and a [NiFe] center, is investigated in the hydrogenase from Desulfovibrio vulgaris Miyazaki F by pulsed ELDOR (electron-electron double resonance). The distance between the metal centers is known from X-ray crystallography. The experimental dipolar spin-spin interaction deviates from the value expected for two point-dipoles located at the centers of the metal clusters. An extended spin-coupling model accounting for the spin coupling in the [3Fe-4S](+) cluster yields the observed interaction under the assumption of a particular magnetic coupling scheme for the three Fe ions. These results demonstrate that pulsed ELDOR can be used to gain insight into the inner structure of a multinuclear metal cluster. 相似文献
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We demonstrate the influence of vectorial coupling on the synchronization behavior of complex systems. We study two semiconductor lasers subject to delayed optical feedback which are unidirectionally coherently coupled via their optical fields. Our experimental and numerical results demonstrate a characteristic synchronization scenario in dependence on the relative feedback phase leading cyclically from chaos synchronization to almost uncorrelated states, and back to chaos synchronization. Finally, we reveal the influence of the feedback phase on the dynamics of the solitary delay system. 相似文献
8.
R.H.?BirknerEmail author J.?Kaiser W.?Els?sser C.?Jung 《Applied physics. B, Lasers and optics》2004,79(8):963-967
We demonstrate the interplay between the intensity noise and the spatial emission characteristics of resonant-cavity light-emitting diodes. First, we find that the total aperture intensity noise exhibits a sub-shot noise behavior in a quite large pumping regime. Second, we investigate the angular, spectral, and spatial emission characteristics of the devices by controlling the shape and width of the angular intensity distribution via temperature detuning of the quantum well wavelength and the cavity resonance wavelength. Finally, the angular and aperture resolved intensity noise exhibit a super-shot noise behavior in contrast to that of the total emission. We explain this difference with anticorrelations between various radial components which increase with the temperature-tuned extension of the spatial emission. PACS 85.60.Jb; 42.50.L; 23.20.En 相似文献
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We demonstrate a novel optical dipole trap that is based on enhancement of the optical power density of a Nd:YAG laser beam in a resonator. The trap is particularly suited for experiments with ultracold gases, as it combines a potential depth of the order of 1 mK with storage times of several tens of seconds. We study the interactions in a gas of fermionic lithium atoms in our trap and observe the influence of spin-changing collisions and off-resonant photon scattering. A key element in reaching long storage times is the use of an ultralow-noise laser. The dependence of storage time on laser noise is investigated. 相似文献
10.
Yves Van Ingelgem Els Tourwé Orlin Blajiev Rik Pintelon Annick Hubin 《Electroanalysis》2009,21(6):730-739
Electrochemical impedance spectroscopy (EIS) is a powerful technique to study electrochemical processes and to perform screening tasks. Recently an integrated measuring and modeling methodology for EIS based on a multisine excitation signal was developed. A key issue in this methodology is the data analysis, allowing us to rapidly quantify the reliability of the measured data. In this paper, a comparison is made between classical single‐sine and the proposed multisine measurements on the same system. The fitting of the impedance data obtained by single‐or multisine excitation and using different weighting factors is also discussed. In addition to the advantages reported in earlier work, it is concluded that, of all investigated frequencies, the odd random phase multisine excitation yields the highest quality data in the shortest measurement time. 相似文献