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J. Ometáková P. Rajec V. Csiba M. Leporis M. ?tefe?ka P. Vlk M. Galambo? O. Rosskopfová 《Journal of Radioanalytical and Nuclear Chemistry》2012,293(1):217-222
64Cu (T1/2?=?12,7?h, ??? 37,1?%, ??+ 17,9?%, EC 41?%) is a useful radioisotopes for positron emission tomography radiopharmaceutical. We used the reaction route 64Ni(p,n)64Cu for the 64Cu preparation. A basic disadvantage of this route, a high price of the enriched target material, was eliminated by using very simple recycling procedure. Compact solid target irradiation system was installed at the end of the external beam line of the IBA Cyclone 18/9 cyclotron. In this paper, the irradiation of 64Ni target and separation of 64Cu from a target material is described. The separation was achieved by anion exchange chromatography with HCl as a elution solution. The distribution ratio for different HCl concentrations on Bio-Rad AG1-X8 and elution profile of 64Cu were investigated. 64Cu production rate for 100?mg 64Ni of 99.09?% purity (ISOFLEX) on gold target was 104?MBq/??Ah. The activity of the product was checked by ionisation chamber (Curiementor), gamma spectrometry using a HPGe detector and liquid scintillation counting using the triple-to-double coincidence ratio method. The separation process of 64Cu was made in a home-made separation module. 相似文献
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Elodie Boisselier Dr. Liyuan Liang Maria Dalko‐Csiba Dr. Jaime Ruiz Dr. Didier Astruc Prof. 《Chemistry (Weinheim an der Bergstrasse, Germany)》2010,16(20):6056-6068
Titrations of commercial diaminobutane (DAB) and polyamidoamine (PAMAM) dendrimers by vitamins C (ascorbic acid, AA), B3 (nicotinic acid), and B6 (pyridoxine) were monitored by 1H NMR spectroscopy using the chemical shifts of both dendrimer and vitamin protons and analyzed by comparison with the titration of propylamine. Quaternarizations of the terminal primary amino groups and intradendritic tertiary amino groups, which are nearly quantitative with vitamin C, were characterized by more or less sharp variations (Δδ) of the 1H chemical shift (δ) at the equivalence points. The peripheral primary amino groups of the DAB dendrimers were quaternarized first, but not selectively, whereas a sharp chemical‐shift variation was recorded for the inner methylene protons near the tertiary amines, thereby indicating encapsulation, when all the dendritic amines were quaternarized. With DAB‐G5‐64‐NH2, some excess acid is required to protonate the inner amino groups, presumably because of basicity decrease due to excess charge repulsion. On the other hand, this selectivity was not observed with PAMAM dendrimers. The special case of the titration of the dendrimers by vitamin B6 indicates only dominant supramolecular hydrogen‐bonding interactions and no quaternarization, with core amino groups being privileged, which indicates the strong tendency to encapsulate vitamins. With vitamin B3, a carboxylic acid, titration of DAB‐G3‐16‐NH2 shows that only six peripheral amino groups are protonated on average, even with excess vitamin B3, because protonation is all the more difficult due to increased charge repulsion, as positive charges accumulate around the dendrimer. Inner amino groups interact with this vitamin, however, thus indicating encapsulation presumably with supramolecular hydrogen bonding without much charge transfer. 相似文献
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P. Rajec V. Csiba M. Leporis M. Štefečka E. Losonczi Pataky M. Reich J. Ometáková 《Journal of Radioanalytical and Nuclear Chemistry》2010,286(3):665-670
The reaction route 64Ni(p,n)64Cu is very popular for the preparation of 64Cu because its entrance channel is accessible at low energies and yield of reaction is quite high. However, a high price of
the enriched 64Ni is a disadvantage of this reaction path; hence, preparation of a chemically pure nickel targets for the production of 64Cu using COSTIS (Compact Solid Target Irradiation System) is of a great research interest. In this paper, effects of boric
acid, composition of electrolytic bath and electrochemical process conditions on the quality of nickel films deposited on
2 mm thick gold or platinum disc targets were investigated. Chemical purity of the electrodeposited nickel was measured by
the Auger electron spectroscopy and the surface quality of targets was studied microscopically (SEM). A SRIM program was used
for a thickness target calculation. COSTIS target station was installed at the end of the external beam line of the IBA Cyclone
18/9 cyclotron, and the irradiation surface of target was optimized. The target station has been equipped with Al or Nb window
foil in the front of the target to degrade the beam energy to an optimal value. 相似文献
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Using new characteristics of an infinite subset of positive integers we give some estimations of the dispersion of the related
block sequence.
Supported by VEGA Grant no. 1/4006/07. 相似文献
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