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Nathan A. Lacher Rachel K. Roberts Yan He Holly Cargill Katrina M. Kearns Heidi Holovics Margaret N. Ruesch 《Journal of separation science》2010,33(2):218-227
Capillary gel electrophoresis (CGE) methods with UV detection were developed for reduced and non‐reduced mAb analysis. These methods can be used to evaluate mAb purity, offering more reproducible quantitation compared with that of traditional SDS‐PAGE methods. These CGE methods have been utilized as platform technology for bioprocess development, formulation development, mAb characterization, drug substance/drug product release testing as well as a required methodology for stability testing. We have found these CGE methods to be applicable across a platform of mAbs in preclinical and clinical development, with the majority of mAbs requiring no modification to the method conditions. This methodology has been ICH validated and transferred to several supporting organizations. The data presented herein describes the development of CGE methodology, platform application to mAb purity analysis, ICH validation, reliability metrics, and considerations on technology enhancement for improved performance and throughput. 相似文献
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We demonstrate that soliton perturbation theory, though widely used, predicts an incorrect phase distribution for solitons of stochastically driven nonlinear Schr?dinger equations in physically relevant parameter regimes. We propose a simple variational model that accounts for the effect of radiation on phase evolution and correctly predicts its distribution. 相似文献
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Matthew R. Cargill David J. Tomlinson Frank Pleis Pinar Kilickiran 《Journal of fluorine chemistry》2011,132(10):829-833
The effects on response times of representative commercially available dielectrically negative (−LC) and positive (+LC) type liquid crystal mixtures doped with small quantities of various tetrafluorinated cycloalkoxyphenyl ether derivatives were investigated. The synthesis of various polyfluoroaryl systems by nucleophilic aromatic substitution processes is described and electro-optical measurements concerning the rise and decay times and voltage holding ratios of each doped LC formulation are reported. The response time of the dielectrically negative LC host was improved upon doping with each of the tetrafluorinated cycloalkoxyphenyl ether derivatives, although no improvement in the performance of the dielectrically positive LC host was achieved. 相似文献
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Partial coordination numbers for a chemically disordered binary amorphous alloy AXABXB are obtained in terms of total coordination numbers Zi and average coordination numbers 〈Z〉 . Departures from complete chemical disorder are characterized by a short-range order coefficient with ηABmax=xBZB/xAZA for XBZB<xAZA and ηABmax=xAZA/xBZB for xBZB>xAZA.For complete chemical disorder νAB0 = 0; for complete chemical order, i.e. with chemical preference for AB nearest neighbor pairs, νAB0 = 1. For departures from chemical disorder associated with clustering, i.e. chemical preference against AB nearest neighbor pairs, νAB0 < 0. Experimental results for several amorphous alloys are used to demonstrate the usefulness of these results. A more precise calculation of ηABmax is necessary to compare the degree of ordering in the metal-metalloid and metal-metal alloys. 相似文献
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Extended X-ray absorption fine structure measurements were used to determine nearest neighbor coordination numbers and distances for As in amorphous Si prepared by 100 keV As ion-implantation of single crystal Si. In the limit of low As concentration, the average As---Si coordination number was 3.2±0.1 and the As-to-Si distance was 2.37±0.02 Å, compared with 4 and 2.41±0.02 Å, respectively, for As in crystalline Si. It is concluded that 20% of the As atoms are fourfold coordinated and 80% are threefold coordinated in the amorphous Si, and that the lack of electrical doping by the fourfold coordinated As results from electron trapping by dangling bonds or other structural defects. 相似文献
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