Vanadium(III) chloride catalyzed Biginelli condensation: solution phase library generation of dihydropyrimidin-(2H)-ones

The three component condensation of an aldehyde, a β-keto ester and urea (thiourea) in the presence of a catalytic amount of VCl₃ is disclosed for the solution phase synthesis of dihydropyrimidinones. The ease of synthesis and work-up allowed the parallel synthesis of a 48-membered library of dihydropyrimidinones quickly and efficiently in good yields.     

Working group report: Flavor physics and model building

This is the report of flavor physics and model building working group at WHEPP-9. While activites in flavor physics have been mainly focused on B-physics, those in model building have been primarily devoted to neutrino physics. We present summary of working group discussions carried out during the workshop in the above fields, and also briefly review the progress made in some projects subsequently.     

Bi-large neutrino mixings by radiative magnification

Starting with the unification hypothesis of mixings of quarks and leptons and small quark-like mixings at the see-saw scale, we find that two large mixings for ν_e —νx03BC; andv _μ—v _τ at the weak scale are obtained as a result of renormalization group evolution and radiative magnification if the three neutrinos are quasi degenerate in masses and possess the same CP parity. We also find thatU _e3 remains small and well within the CHOOZ-Palo Verde bound since the correspondingV _ub for CKM mixing is very small. Several testable pedictions are pointed out.     

Sulfated nanozirconia: an investigation on acid-base properties and n-butane isomerization activity

Hydrated zirconia was synthesized by an organo-inorganic route employing surfactant and was sulfated using aqueous ammonium persulfate, followed by drying at 110 degrees C. The sample thus obtained was calcined at 600 degrees C to obtain sulfated zirconia and was characterized by several physicochemical methods. Crystallite sizes of sulfated zirconia were calculated from X-ray line broadening using the Debye-Scherer equation and were found to be in the range of 25 nm. When pretreated in air, the catalyst was found to exhibit butane isomerization activity at a temperature as low as 35 degrees C under atmospheric pressure. It showed conversion as high as 37% at 100 degrees C under normal pressure when pretreated in air, whereas nitrogen-pretreated catalyst showed zero activity under similar conditions. NH(3) and CO(2) temperature-programmed desorption studies on air- and helium-pretreated samples indicated that the catalyst surface changes appreciably during air pretreatment. Results on butane isomerization in conjunction with TPD studies suggest that zirconium-oxy sites play an important role in butane activation during the reaction.     

2‐Pyrazolines from 1,3 ‐ dipolar cycloaddition of diazomethane to arylsulfonylethenes

Novel 2‐pyrazolines were obtained by the cycloaddition of diazomethane to bis(arylsulfonylethenyl)‐sulfones ( 3 ) and 1‐arylsulfonyl‐2‐styrylsulfonylethenes (7). Dehydrogenation of 2‐pyrazolines with chloranil gave pyrazoles.     

An efficient synthesis of (+)-prelactone B

An enantioselective synthesis of (+)-prelactone B 1 has been achieved on a multigram scale starting from a known bicyclic precursor 2. The key feature of the strategy is the generation of 3-stereogenic centres from a single bicyclic precursor, which has been utilized as a chiral building block for the synthesis of various natural products.     

Two new 5-deoxyflavones from Albizia odoratissima

Two new 5-deoxyflavones, 7,8-dimethoxy-3',4'-methylenedioxyflavone (1) and 7,2',4'-trimethoxyflavone (2) together with a known flavone, 7,4'-dimethoxy-3'-hydroxyflavone (3) were isolated from the rootbark of Albizia odoratissima. The structures of these new compounds were elucidated by electrospray ionization mass spectrometry (ESI-MS) and 1D and 2D-NMR spectral studies including (1)H-(1)H correlation spectroscopy (COSY), heteronuclear single quantum coherence (HSQC), heteronuclear multiple bond connectivity (HMBC) and nuclear Overhauser enhancement spectroscopy (NOESY).