Protonation studies on the oximes of some 7-acetyl-1,2-benzisothiazoles

Three 7-acetyl-1,2-benzisothiazoles have been made by cyclisation of the monooximes of 2-methylthio-1,3-diacetylbenzenes. The oximes of these ketones dissolved in acidic media give only protonated forms, and no indication of the formation of stable bridged sulfonium ions.     

The synthesis of two benzo[c:d′]diisothiazoles

Two benzo[c:d']diisothiazoles, 8-methylbenzo[1,2-c:5,6-d']diisothiazole and 3-methylbenzo[1,2-c:6,5-d']diisothiazole, have been made by reaction of appropriate aminomethyl-1,2-benzisothiazoles with N-sulfinylmeth-anesulfonamide.     

The 27Al(t,p)29Al reaction at Et = 15 MeV

The ²⁷Al(t, p)²⁹Al reaction was studied at an incident energy of E_t = 15 MeV. Proton angular distributions were measured for the first 23 low-lying states. Comparisons of the data to DWBA calculations based on cluster-model and pure-configuration form factors were made which provided decompositions of the angular distributions into contributing L-values. Comparisons were also made to DWBA predictions based on microscopic amplitudes from a complete, sd-basis shell-model calculation.     

Critical Exponents from the Resummed Effective Potential of the ({\frac{g}{4}}\phi^{4}-J\phi)_{1+1} Scalar Field Theory

We establish a unified way for the calculation of the critical exponents, without the use of epsilon expansion, through the improvement of the perturbative effective potential of the 1+1 dimensional $({\frac{g}{4}}\phi^{4}-J\phi)$ scalar field theory. First, we obtain the perturbation series for the effective potential up to g ³. We improved the perturbative effective potential by establishing a parameter-free resummation algorithm, originally due to Kleinert, Thoms and Janke, which has the privilege of using the strong coupling as well as the large coupling behaviors rather than the conventional resummation techniques which use only the large order behavior. Accordingly, although the perturbation series available is up to g ³ order, we found a complete agreement between our resummed effective potential and the well known features from constructive field theory. We prove that the 1-PI correlation functions and the effective potential ought to have the same large order as well as strong coupling behaviors. We computed the critical exponents and our results show a good agreement with the exact Ising model values.     

Search for the standard model Higgs boson in the diphoton decay channel with 4.9 fb(-1) of pp collision data at √s=7 TeV with ATLAS

A search for the standard model Higgs boson is performed in the diphoton decay channel. The data used correspond to an integrated luminosity of 4.9 fb(-1) collected with the ATLAS detector at the Large Hadron Collider in proton-proton collisions at a center-of-mass energy of √s=7 TeV. In the diphoton mass range 110-150 GeV, the largest excess with respect to the background-only hypothesis is observed at 126.5 GeV, with a local significance of 2.8 standard deviations. Taking the look-elsewhere effect into account in the range 110-150 GeV, this significance becomes 1.5 standard deviations. The standard model Higgs boson is excluded at 95% confidence level in the mass ranges of 113-115 GeV and 134.5-136 GeV.     

The synthesis of some benzo[d,d']diisothiazoles

Four examples of benzo[d,d']diisothiazoles have been made by cyclisation of appropriate o-alkylthioaryl-ketoximes by simultaneous or consecutive ring formation.     

Mineralized Polyvinyl Alcohol/Sodium Alginate Hydrogels Incorporating Cellulose Nanofibrils for Bone and Wound Healing

Bio sustainable hydrogels including tunable morphological and/or chemical cues currently offer a valid strategy of designing innovative systems to enhance healing/regeneration processes of damaged tissue areas. In this work, TEMPO-oxidized cellulose nanofibrils (T-CNFs) were embedded in alginate (Alg) and polyvinyl alcohol (PVA) solution to form a stable mineralized hydrogel. A calcium chloride reaction was optimized to trigger a crosslinking reaction of polymer chains and mutually promote in situ mineralization of calcium phosphates. FTIR, XRD, SEM/EDAX, and TEM were assessed to investigate the morphological, chemical, and physical properties of different mineralized hybrid hydrogels, confirming differences in the deposited crystalline nanostructures, i.e., dicalcium phosphate dehydrate (DCPDH) and hydroxyapatite, respectively, as a function of applied pH conditions (i.e., pH 4 or 8). Moreover, in vitro tests, in the presence of HFB-4 and HSF skin cells, confirmed a low cytotoxicity of the mineralized hybrid hydrogels, and also highlighted a significant increase in cell viability via MTT tests, preferentially, for the low concentration, crosslinked Alg/PVA/calcium phosphate hybrid materials (<1 mg/mL) in the presence of hydroxyapatite. These preliminary results suggest a promising use of mineralized hybrid hydrogels based on Alg/PVA/T-CNFs for bone and wound healing applications.     

Sorption of Cadmium from Aqueous Solutions at Different Temperatures by Mexican HEU-type Zeolite Rich Tuff

Many factors may affect the heavy metals sorption on natural zeolites among them the temperature, for this reason in this paper the cadmium retention behavior on Mexican zeolitic rich tuff as a function of temperature is considered. The kinetic and the isotherms were determined at 303, 318, and 333 K, the remaining cadmium in the solution samples was analyzed by atomic absorption spectrometry. The pseudo-second order rate constant, k, as well as the apparent diffusion coefficients were calculated from the cadmium uptake by the zeolitic rock as a function of the contact time and temperature, the highest amounts were found for the experiments done at 333 K. The maximum cadmium adsorption capacity by the zeolitic material was 12.2 mg Cd²⁺/g at 318 K corresponding to 20% of the effective ion exchange capacity of the Chihuahua zeolitic rock. In order to explain the cadmium sorption behavior different kinetics and isotherm models were considered.     

Full-Energy peak efficiency of an NaI(Tl) detector with coincidence summing correction showing the effect of the source-to-detector distance

The coincidence summing effect is considered to be one of the most important problems in γ-ray spectrometry. It has played an important role in the detector calibration process, especially at low source-to-detector distances, which are the typical conditions when the environmental samples have to be measured. In this work, the γ–γ coincidence summing correction factors (CSCF) for a 3″×?3″ NaI(Tl) γ-ray detector have been calculated at different distances from the detector end cap. These factors with NaI(Tl) γ-ray detectors have rarely been discussed in the previous literature, due to the lack of the separation process of the close gamma energy lines in the scintillation detector spectrum. The γ–γ CSCF were calculated for ⁶⁰Co, ¹³³Ba and ¹⁵²Eu radioactive point sources, which show the simple and the complex decay scheme of several radionuclides. In order to obtain the CSCF, the following parameters must be estimated by the numerical simulation method (NSM): the total efficiency (ε_T), the full-energy peak efficiency (ε_P) and the effective solid angle (Ω_eff). These parameters were calculated numerically depending on the direct mathematical method and efficiency transfer method. The obtained CSCF was used to correct the measured efficiency curves, which were measured at different distances, then compared to the ETNA and EFFTRAN programs, as well as the CSCF. The results show a good agreement, especially at large source-to-detector distances.     

Synthesis and Computational Analysis of New Antioxidant and Antimicrobial Angular Chromenopyrimidines

A convenient synthetic protocol for the synthesis of novel chromenopyrimidine derivatives based on angular scaffold has been developed from the readily available enaminonitrile precursor 1 . The skeleton of chromenopyrimidines has been decorated with different moieties in order to approach compounds with improved antioxidant and antimicrobial activities. Compound 1 was reacted with Ac₂O to yield benzochromenopyrimidine 6 that gave chloropyrimidine 7 via chlorination reaction. The reaction of chloropyrimidine 7 with different amines afforded a series of benzochromenopyrimidines 9 – 12 . The hydrazine 11 and hydrazide 13 derivatives showed excellent antioxidant activity in addition to the potent antimicrobial activity revealed by aminopyrimidines 10 and 16 . Computational docking studies indicated the potential recognition of compound 13 towards antioxidant binding site. Dual evaluations of the antimicrobial affinity of compound 16 indicated its promising activity as antimicrobial lead.