A phase I, randomized study of combined IL-2 and therapeutic immunisation with antiretroviral therapy

Background  

Fully functional HIV-1-specific CD8 and CD4 effector T-cell responses are vital to the containment of viral activity and disease progression. These responses are lacking in HIV-1-infected patients with progressive disease. We attempted to augment fully functional HIV-1-specific CD8 and CD4 effector T-cell responses in patients with advanced chronic HIV-1 infection.     

Numerical Simulation of Magnetoresonance Absorption for Multilayered Co/Cu Nanostructures in the Millimeter Waveband

The numerical simulation of the Ferromagnetic Resonance (FMR) absorption in the millimeter waveband has been performed for magnetic multilayered nanostructures. The model taking into account a random bilinear exchange interaction between layers was applied for the theoretical approach elaboration. Results of the simulation are in good agreement with experimental data registered for samples of nanostructure Co/Cu with buffer layer Fe in the frequency band 20-37 GHz. The explanation of the origin of unexpectedly broad magnetoresonance peaks formed in specimen under study is suggested.     

Generalized Ginzburg-Landau functional calculations of the structure and energy of the coherent interphase boundaries between austenite and martensite in iron

The earlier-developed methods and experimental data on the phonon spectra and thermodynamics of fcc and bcc iron are used to construct a generalized Ginzburg-Landau functional for microscopic investigations of the austenite-martensite phase transformations in iron. This functional is used to calculate the structure and properties of a plane austenite-martensite interface for arbitrary orientations of this interface at various temperatures. The transformation parameter profiles in the interface region are calculated. The interface width is found to substantially exceed the interatomic distances. The interfacial surface energy is 500?C800 erg/cm², depends strongly on the orientation, and has a sharp maximum when the interface is parallel to a close-packed plane.     

Statistical calculations of tracer and intrinsic diffusion coefficients in concentrated alloys and estimates of microscopic parameters of diffusion from experimental data

The earlier-developed statistical theory of diffusion in concentrated alloys based on the master equation approach is generalized to treat tracer diffusion in binary alloys. The theory developed is used to describe concentration dependencies of both tracer and intrinsic diffusion coefficients and to estimate microscopic parameters of diffusion in alloys CuNi, CuZn and AgCd for which necessary experimental data are available. We show that all main features of strong and peculiar concentration dependencies of diffusion coefficients observed in these alloys are naturally explained by the theory. Signs and scales of interatomic interactions important for diffusion in these alloys are found to strongly depend on the ratio of atomic sizes of alloy components, and types of these dependencies agree with simple physical considerations. We also discuss physical reasons for sharp concentration dependencies of diffusion coefficients characteristic of real alloys.     

Femtosecond vibrational dynamics of self-trapping in a quasi-one-dimensional system

We have directly time resolved the lattice motions associated with the formation of the self-trapped exciton in the quasi-one-dimensional system [Pt(en)(2)] [Pt(en)2Br2];(PF6)(4) ( en = ethylene-diamine, C2H8N2), using femtosecond impulsive excitation techniques. A strongly damped, low-frequency wave packet modulation at approximately 110 cm(-1) accompanies the formation of the self-trapped exciton on a approximately 200 fs time scale following excitation of the intervalence charge-transfer transition. Coherent oscillations at the ground state vibrational frequency and its harmonics are also detected.