带电粒子致细胞失活的理论模型(英文)

介绍了经辐射损伤后细胞失活或存活的理论模型及相关问题的一些研究工作。重点考虑了径迹结构和能量沉积特点的新的细胞失活模型。在径迹结构模拟的基础上, 计算并分析了DNA损伤谱, 同时把径迹结构得到的损伤谱与细胞存活联系起来, 初步在分子水平上理解了细胞失活或存活的机制。The several theoretical models of cell inactivation or cell survival fraction are introduced. Emphasis is placed on a new model——Ionization Ionization Clustering Cluster model. In order to understand some of the mechanisms of DNA damage related to cell killing and their dependence on radiation quality, the yields of single track lethal events are compared with the estimated yields of different classes of complex DNA lesions calculated by a fast Monte Carlo methods.     

低能电子在水介质中的输运过程

考虑到低能电子(能量下限为1eV)在水中输运时的电离,激发,俘获以及超激发引起的自电离等非弹性散射机制,并且考虑到OH⁺,H⁺等自由基的产生和分布,运用Monte Carlo方法模拟了电子在水中输运的径迹结构,揭示了电子在低能情况下输运时单条轨道的空间分布结构特点(云团,团点和短径迹等空间分布实体)和包含在大量轨道中的径迹结构的统计性质,并通过对比截止能量取30和1eV两种情况,分析了30eV以下的低能电子的作用.     

辐射致DNA损伤及相关生物-化学-物理问题(英文)

介绍了在DNA辐射损伤以及相关生物、物理、化学问题的一些研究工作。重点是径迹结构、DNA双链断裂和细胞学终点的关系。P53-Mdm2负反馈回路在DNA损伤的细胞响应方面起重要作用,用一个简单的模型研究了P53-Mdm2负反馈回路相互作用的动力学行为。Some of recent works are presented on radiation induced DNA damage being carried out at China Institute of Atomic Energy （CIAE） and related bio-chemi-physical problems. Emphasis is placed on track structure and its relation to the cell end-point, and a simple model proposed to study the dynamical behavior of P53-Mdm2 interaction which plays pivotal role in cellular response to DNA damage.