太赫兹金属器件电铸工艺中电流密度研究

微电铸工艺是太赫兹全金属光栅器件成型的关键工序。金属光栅质量取决于电铸工艺中金属离子沉积的均匀性, 而电铸槽阴极附近电流密度的分布直接影响金属离子沉积的均匀性。在阳极与阴极间添加开孔的绝缘玻璃挡板可以改善阴极电流密度分布的均匀性, 研究了挡板与阴极的距离以及挡板开孔大小对阴极电流密度分布的影响, 仿真结果表明: 添加开孔绝缘挡板有助于改善阴极处的电流密度分布; 当添加的玻璃挡板开孔大小与阴极尺寸一致时, 挡板距离阴极越近, 阴极的电流密度分布越均匀。根据仿真结果设计了相应的挡板, 电铸工艺获得了较好质量的均匀金属层, 从而验证了上述仿真分析的有效性。     

Cascaded strand displacement for non-enzymatic target recycling amplification electrochemical detection of SARS-CoV-2EI北大核心CSCD

An electrochemical biosensor for low cost and highly sensitive and selective detection of SARS-CoV-2 target nucleic acid was developed based on two cascaded toehold-mediated strand displacement reactions (TSDRs). Driven by thermodynamic entropy, the target nucleic acid bound to the first toehold region of the probes, leading to the first TSDR and the second toehold region exposed. Subsequently, the methylene blue (MB)-modified signal probe triggered the second TSDR and led to cyclic reuse of the target nucleic acid. Based on cascaded TSDRs, a large number of signal probes were combined on the sensor surface to produce significantly enhanced square wave voltammetry (SWV)electrochemical signals. The results showed that the SWV signal intensity was proportional to the logarithm of the target nucleic acid concentration, and had a good linear relationship in the range of 5×10-14-5×10-10 mol/L with a detection limit of 1.8×10-14 mol/L. Moreover, the sensor could be employed to monitor SARS-CoV-2 nucleic acid in 10% serum samples. © 2023, Youke Publishing Co.,Ltd. All rights reserved.