α—h—ANF及其类似物的固相合成及活性研究

由计算机辅助设计.以Fmoc-AA-Pfp为单体,用固相法合成了a-h-ANF及其两种类似物,产率较高.兔心血管收缩试验表明,两种类似物的血管舒张活性均高于a-h-ANF.     

Rotational viscosity of a liquid crystal mixture: a fully atomistic molecular dynamics study

Fully atomistic molecular dynamics (MD) simulations at 293, 303 and 313~K have been performed for the four-component liquid crystal mixture, E7, using the software package Material Studio. Order parameters and orientational time correlation functions (TCFs) were calculated from MD trajectories. The rotational viscosity coefficients (RVCs) of the mixture were calculated using the Nemtsov--Zakharov and Fialkowski methods based on statistical-mechanical approaches. Temperature dependences of RVC and density were discussed in detail. Reasonable agreement between the simulated and experimental values was found.     

Determining the resistance of X-pinch plasma

The current and the voltage of an X-pinch were measured. The inductance of the X-pinch was assumed to be a constant and estimated by the calculation of the magnetic field based on the well-known Biot-Savart's Law. The voltage of the inductance was calculated with L · di/dt and subtracted from the measured voltage of the X-pinch. Then, the resistance of the X-pinch was determined and the following results were obtained. At the start of the current flow the resistance of the exploding wires is several tens of Ohms, one order of magnitude, higher than the metallic resistance of the wires at room temperature, and then it falls quickly to about 1 , which reflects the physical processes occurring in the electrically exploding wires, i.e., a current transition from the highly resistive wire core to the highly conductive plasma. It was shown that the inductive contribution to the voltage of the X-pinch is less than the resistive contribution. For the wires we used, the wires' material and diameter have no strong influence on the resistance of the X-pinch, which may be explained by the fact that the current flows through the plasma rather than through the metallic wire itself. As a result, the current is almost equally divided between two parallel X-pinches even though the diameter and material of the wires used for these two X-pinches are significantly different.     

声学反问题的整体唯一性

It is proved that a sound-soft scatterer in R^N （N = 2, 3） is uniquely determined by a finite number of acoustic far-field measurements. The admissible scatterer possibly consists of finitely many solid obstacles and subsets of （N - 1）- dimensional hyperplanes.     

美式回望期权定价问题的有限体积法

随着金融市场的不断发展, 期权作为一种能够规避风险的金融衍生产品越来越引起投资者的青睐, 成交量呈逐年上升的趋势, 期权定价问题已经成为金融数学领域中一个重要的研究课题. 本文主要研究Black-Scholes模型下美式回望期权定价问题的数值解法. 美式回望期权定价问题是一个二维非线性抛物问题, 难以直接应用数值方法进行求解. 通过分析该问题的求解难点, 本文给出解决该困难的有效方法. 首先利用计价单位变换将定价问题转换为一维自由边值问题, 并采用Landau's变换将求解区域规范化; 而后针对问题的非线性特点,利用有限体积法和Newton法交替迭代求解期权价格和最佳实施边界, 并对数值解的非负性进行了分析. 最后, 通过与二叉树方法进行比较, 验证了本文方法的正确性和有效性, 为实际应用提供了理论基础.     

荧光法和液相色谱-质谱联用法测定司莫司汀导致λDNA交联率的比较研究

司莫司汀是重要的抗癌烷化剂,其抗癌机制与导致DNA股间交联有关.使用荧光法和高效液相色谱-电喷雾串联质谱联用(HPLC-ESI-MS/MS)法对司莫司汀导致的λDNA交联率进行了测定.结果表明:药物浓度为2,4,8和16mmol/L时,荧光方法测得的最大交联率分别为8.81%,11.17%,17.61%,和23.39%...     

箍缩背光照相

 利用PPG-Ⅰ脉冲功率装置（500 kV,400 kA,100 ns）驱动X箍缩负载,得到了μm量级的亚纳秒脉冲X射线辐射点源。在阴阳极轴线和回流柱上同时安装X箍缩负载,前者可作为背光照相的X射线点源;后者可作为被拍照的目标X箍缩。获得了X箍缩发展过程不同时刻的时间序列图像,在背光照相的图像中可以清晰观察到X箍缩交叉点处等离子体的外爆、箍缩以及最终的崩溃阶段。将阴阳极轴线上的X箍缩负载用Z箍缩丝阵负载代替,实现了对丝阵负载Z箍缩放电起始阶段的X射线背光照相,观察到了最初的各单丝电爆炸、等离子体膨胀及融合过程,同时观察到了双丝Z箍缩发展过程中的等离子体不稳定性。实验结果有助于深入理解Z箍缩发展的物理过程,同时可为有效的模拟建模分析提供基本的实验数据。     

连续氙灯发光光谱的设计与应用研究

对太阳实际光谱与连续氙灯的光谱进行了测试,结果显示氙灯发光光谱的红外部分占全部光谱的55.6%,与实际太阳光谱的28.4%有较大差别。依据这种差别进行光谱曲线拟合,得到925 nm最低点的透过率曲线。采用滤光片对氙灯发光光谱的红外部分光强进行适当过滤,测得过滤后的光谱达到标准匹配度。通过测试滤光后6个不同位置点的光谱发现,光谱最大偏差仅为12.5%,表明过滤后的氙灯光谱均匀性较好。利用电致发光检测有缺陷的硅电池进行电池的电性能测试,发现经过采用滤光片和未采用滤光片的连续氙灯光照测试的Ⅰ-Ⅴ电性能值不同,功率相差0.22 W,表明氙灯光谱匹配度直接影响电池电性能测试的准确度。     

电镀铜实验中镀层性质及其影响因素的探究*

电镀实验是电解原理应用的重要案例,通过实验不仅要获得定性的感性认知,还应该获得定量的理性数据。针对电镀铜实验,通过改变铜离子浓度、pH、电解时间、电解电压和电解温度等因素,探究其对镀层厚度、均匀性和致密性等性质的影响,在电解原理的基础上分析其形成机制,从而确定了电镀铜较适宜的操作条件,以此为学生开展电镀实验提供参考案例与研究思路。