Novel dual inhibitors against FP-2 and PfDHFR as potential antimalarial agents: Design,synthesis and biological evaluation

A series of novel 2,4-diaminopyrimidine-modified compounds was designed and synthesized. Compound 14 showed micromolar dual inhibitory effect on both FP-2 and PfDHFR, and potential inhibition to the proliferation of P. falciparum 3D7 strain and chloroquine-resistant P. falciparum Dd2 strain.     

食品中邻苯二甲酸酯类塑化剂的测定及迁移研究进展

综述了2009年以来食品中邻苯二甲酸酯类(PAEs)塑化剂在来源、分析测定方法及迁移方面的研究进展。提出了目前国内邻苯二甲酸酯检验时遇到的主要问题,以及面对食品危机应采取的态度。     

Helical supramolecular nanorods via sequential meticulous tailoring of noncovalent interaction and light irradiation

Science China Chemistry - Polymers are widely recognized to entail random conformations in good solvent governed by the need for achieving the highest entropy to reach thermodynamic equilibrium. In...     

A Non-Conjugated Polymer Acceptor for Efficient and Thermally Stable All-Polymer Solar Cells

A non-conjugated polymer acceptor PF1-TS4 was firstly synthesized by embedding a thioalkyl segment in the mainchain, which shows excellent photophysical properties on par with a fully conjugated polymer, with a low optical band gap of 1.58 eV and a high absorption coefficient >10⁵ cm⁻¹, a high LUMO level of −3.89 eV, and suitable crystallinity. Matched with the polymer donor PM6, the PF1-TS4-based all-PSC achieved a power conversion efficiency (PCE) of 8.63 %, which is ≈45 % higher than that of a device based on the small molecule acceptor counterpart IDIC16. Moreover, the PF1-TS4-based all-PSC has good thermal stability with ≈70 % of its initial PCE retained after being stored at 85 °C for 180 h, while the IDIC16-based device only retained ≈50 % of its initial PCE when stored at 85 °C for only 18 h. Our work provides a new strategy to develop efficient polymer acceptor materials by linkage of conjugated units with non-conjugated thioalkyl segments.     

1.3 GHz超导腔磁通排出效应研究

设计并搭建了一套高精度的磁场测量和补偿系统,并结合中国科学院高能物理研究所(IHEP)的2K超导腔垂直测试平台对1.3 GHz单加速间隙超导腔的磁通排出效应开展了实验研究:利用研制的磁场测量和补偿系统能够精密地测量超导腔赤道位置磁场,并能够将磁场补偿至小于5.0×10-8 T;并对超导腔不同表面温度梯度下的磁通排出效应进行了测量分析;对钉扎了磁场的超导腔进行了射频性能测试,研究了超导腔电阻对磁通钉扎的敏感度,以及在不同电场梯度下超导腔的表面电阻变化情况。结果表明,研制的高精度磁场测量和补偿系统能够满足超导腔磁通排出研究的需求;高的超导腔表面温度梯度有利于磁通的排出;磁通钉扎电阻的敏感度随着加速电场梯度的增加而增大,导致超导腔的性能下降。此实验研究也为后续超导腔的研制奠定了一定基础。     

非定常的热传导-对流问题的非线性Galerkin混合元法(Ⅲ):时间二阶精度的全离散格式

In this paper, a fully discrete format of nonlinear Galerkin mixed element method with two-step discretization of time for the non stationary conduction-convection problems is presented. The existence and the convergence of the fully discrete mixed element solution are shown. On the basis of [9] and [10], we have proved that the schemes have second-order convergence accuracy for the time discretization.     

A reduced finite volume element formulation and numerical simulations based on POD for parabolic problems

A proper orthogonal decomposition (POD) method is applied to a usual finite volume element (FVE) formulation for parabolic equations such that it is reduced to a POD FVE formulation with lower dimensions and high enough accuracy. The error estimates between the reduced POD FVE solution and the usual FVE solution are analyzed. It is shown by numerical examples that the results of numerical computation are consistent with theoretical conclusions. Moreover, it is also shown that the reduced POD FVE formulation based on POD method is both feasible and highly efficient.     

使用CCD测量玻璃管内液体界面位置的灵巧测量头

本文介绍一种使用线阵ＣＣＤ进行玻璃管内液位测量的光电测量头。与其他ＣＣＤ尺寸测量的光学系统不同，本文依据不同的液体具有不同的折射率，提出利用柱形容器中液体的聚光特性，得到两种不同液体的分界面在线阵ＣＣＤ上清晰的像。     

使用多个线阵CCD-计算机系统实时监控多界面位置

本文提出一套多界面位置实时监控系统。该系统采用八个线阵ＣＣＤ像感器分别接收每个界面的光学图像。按照控制程序的设定，适时点亮界面的照明光源，同时驱动ＣＣＤ开始工作，并在采集完界面位置信息后，关掉照明光源及ＣＣＤ，以延长系统的寿命，实现长期连续工作。为了同时分别监控多个界面，设计了专用微机接口电路，通过硬件电路实现各界面数据的同时锁存，然后将每个ＣＣＤ的光电信号采入计算机，解决了目视读数无法保证多处数据在时间上一致性的困扰。运用该系统监控多处油水界面，每处均可在１００ｍＬ体积的检测管内测量到０．１ｍＬ的界面变化。