Nonlinear evolution of the lower-hybrid drift instability in a current sheet

The lower-hybrid drift instability is simulated in an ion-scale current sheet using a fully kinetic approach with values of the ion to electron mass ratio up to m(i)/m(e)=1836. Although the instability is localized on the edge of the layer, the nonlinear development increases the electron flow velocity in the central region resulting in a strong bifurcation of the current density and significant anisotropic heating of the electrons. This dramatically enhances the collisionless tearing mode and may lead to the rapid onset of magnetic reconnection for current sheets near the critical scale.     

The energy conserving particle-in-cell method

A new particle-in-cell (PIC) method, that conserves energy exactly, is presented. The particle equations of motion and the Maxwell’s equations are differenced implicitly in time by the midpoint rule and solved concurrently by a Jacobian-free Newton Krylov (JFNK) solver. Several tests show that the finite grid instability is eliminated in energy conserving PIC simulations, and the method correctly describes the two-stream and Weibel instabilities, conserving exactly the total energy. The computational time of the energy conserving PIC method increases linearly with the number of particles, and it is rather insensitive to the number of grid points and time step. The kinetic enslavement technique can be effectively used to reduce the problem matrix size and the number of JFNK solver iterations.     

Transition of MHD kink-stability properties between line-tied and non-line-tied boundary conditions

Magnetic flux tubes or flux ropes in plasmas are important in nature and the laboratory. Axial boundary conditions strongly affect flux rope behavior, but this has never been systematically investigated. We experimentally demonstrate for the first time axial boundary conditions that are continuously varied between ideal magnetohydrodynamic (MHD) line-tied (fixed) and non-line-tied (free). In contrast with the usual interpretation that mechanical plasma motion is MHD line-tied to a conducting boundary, we constrain boundary plasma motion to cause the line-tied condition.     

Micro-macro coupling in plasma self-organization processes during island coalescence

The collisionless island coalescence process is studied with particle-in-cell simulations, as an internal-driven magnetic self-organization scenario. The macroscopic relaxation time, corresponding to the total time required for the coalescence to complete, is found to depend crucially on the scale of the system. For small-scale systems, where the macroscopic scales and the dissipation scales are more tightly coupled, the relaxation time is independent of the strength of the internal driving force: the small-scale processes of magnetic reconnection adjust to the amount of the initial magnetic flux to be reconnected, indicating that at the microscopic scales reconnection is enslaved by the macroscopic drive. However, for large-scale systems, where the micro-macro scale separation is larger, the relaxation time becomes dependent on the driving force.     

Antiparkinson prodrugs

Parkinson's disease (PD) is a progressive, neurodegenerative disorder which involves the loss of dopaminergic neurons of the substantia nigra pars compacta. Current therapy is essentially symptomatic, and L-Dopa (LD), the direct precursor of dopamine(DA), is the treatment of choice in more advanced stages of the disease. Substitution therapy with LD is, however, associated with a number of acute problems. The peripheral conversion of LD by amino acid decarboxylase (AADC) to DA is responsible for the typical gastrointestinal (nausea, emesis) and cardiovascular (arrhythmia, hypotension) side effects. To minimize the conversion to DA outside the central nervous system (CNS) LD is usually given in combination with peripheral inhibitors of AADC (carbidopa and benserazide). In spite of that, other central nervous side effects such as dyskinesia, on-off phenomenon and end-of-dose deterioration still remain. The main factors responsible for the poor bioavailability and the wide range of inter- and intra-patient variations of plasma levels are the drug's physical-chemical properties: low water and lipid solubility, resulting in unfavourable partition, and the high susceptibility to chemical and enzymatic degradation. In order to improve the bioavailability, the prodrug approach appeared to be the most promising and some LD prodrugs have been prepared in an effort to solve these problems. We report here a review of progress in antiparkinson prodrugs, focusing on chemical structures mainly related to LD, DA and dopaminergic agonists.     

Analysis of non-Maxwellian fusion reaction rates with electron screening

The resonantT(d, n)⁴He and non-resonant³He(³He, 2p)⁴He fusion reactions are analysed. Their thermal reactivities are calculated, assuming that the distribution function of the reacting nuclei could be non-Maxwellian. This analysis can be performed by means of the Abramowitz's functions, their generalization, and asymptotic expansions at lowT, which are derived here. Analytical expressions of reactivities are given and the effects of deviations from Maxwellian distribution and of the electron screening are discussed.     

Electron self-reinforcing process of magnetic reconnection

The growth of collisionless magnetic reconnection is discovered to be a nonlinear electron self-reinforcing process. Accelerated by the reconnection electric field, the small portion of energetic electrons in the vicinity of the X point are found to be the cause of the fast reconnection rate. This new mechanism explains that recent simulation results of different reconnection evolutions (i.e., steady state, quasisteady state, or nonsteady state) are essentially determined by the availability of feeding plasma inflows. Simulations are carried out with open boundary conditions.     

Current-driven rotating-kink mode in a plasma column with a non-line-tied free end

First experimental measurements are presented for the kink instability in a linear plasma column which is insulated from an axial boundary by finite sheath resistivity. An instability threshold below the classical Kruskal-Shafranov threshold, axially asymmetric mode structure, and rotation are observed. These are accurately reproduced by a recent kink theory, which includes axial plasma flow and one end of the plasma column that is free to move due to a non-line-tied boundary condition.