Voice changes in women treated for endometriosis and related conditions: The need for comprehensive vocal assessment

Hormonal treatments which have an androgenic effect have the potential to cause vocal changes. The changes in vocal fold structure and voice quality are considered to be irreversible. To date, studies have documented subjective vocal changes or documented single cases without detailed, baseline voice assessments. The impact on laryngeal function of women taking these androgenic treatments requires further detailed, objective assessment. The need for increased awareness of the actions of androgenic hormones on womns' voices, and the benefits of a thorough voice assessment are discussed.     

Pharmaceutical applications of variable-angle synchronous scanning fluorescence spectroscopy

The development of variable-angle synchronous scanning (v.a.s.s.) in fluorescence spectrometry is reported, based on a computer-aided spectrofluorimeter. The technique permits a linear path to be scanned at any preselected angle through the emission-excitation matrix defined by (I_em, λ_em, λ_ex), by effectively scanning the emission and the excitation monochromators at different speeds under computer control. When applied to pharmaceutical dosage forms, v.a.s.s. gave good selectivity for chlorpromazine in the presence of its principal degradation product, chlorpromazine sulphoxide, and for oxytetracycline in the presence of the additives vitamin C, thiamine, nicotinamide and riboflavin. Good calibration linearity, precision and recovery were observed for both principal drug components. The angle of the scan trajectory can also be varied continuously through the emission-excitation matrix, to describe any desired path under computer control. This novel technique of non-linear v.a.s.s. can provide an improved method for generating diagnostic profiles of drugs, degradation products and metabolites.     

Determination of the axial-vector weak coupling constant with ultracold neutrons

A precise measurement of the neutron decay β asymmetry A? has been carried out using polarized ultracold neutrons from the pulsed spallation ultracold neutron source at the Los Alamos Neutron Science Center. Combining data obtained in 2008 and 2009, we report A? = -0.119?66±0.000?89{-0.001?40}{+0.001?23}, from which we determine the ratio of the axial-vector to vector weak coupling of the nucleon g{A}/g{V}=-1.275?90{-0.004?45}{+0.004?09}.     

Fast handheld two-photon fluorescence microendoscope with a 475 microm x 475 microm field of view for in vivo imaging

A fast handheld two-photon fiber-optic fluorescence endoscope for three-dimensional (3D) in vivo cellular imaging is developed. The compact handheld probe of the two-photon endoscope can simply be placed into contact with the target tissue to reveal clear 3D surface and subsurface histological images without biopsy. The new system has, to the best of our knowledge, the largest field of view (FOV) of 475 microm x 475 microm and a 3D imaging volume larger than 475 microm x 475 microm x 250 microm. A real-time two-photon fluorescence image is displayed at 0.4 mm(2)/s. The lateral and axial resolutions of the two-photon fluorescence endoscope are better than 1 and 14.5 microm, respectively.     

Domination critical graphs

A set of vertices S is said to dominate the graph G if for each v ? S, there is a vertex u ∈ S with u adjacent to v. The smallest cardinality of any such dominating set is called the domination number of G and is denoted by γ(G). The purpose of this paper is to initiate an investigation of those graphs which are critical in the following sense: For each v, u ∈ V(G) with v not adjacent to u, γ(G + vu) < γ(G). Thus G is k-y-critical if γ(G) = k and for each edge e ? E(G), γ(G + e) = k ?1. The 2-domination critical graphs are characterized the properties of the k-critical graphs with k ≥ 3 are studied. In particular, the connected 3-critical graphs of even order are shown to have a 1-factor and some stringent restrictions on their degree sequences and diameters are obtained.