Polyurea microcapsules from isocyanatoethyl methacrylate copolymers

The synthesis of two types of isocyanate side chain containing copolymers, poly(methyl methacrylate‐co‐isocyanatoethyl methacrylate) (P(MMA‐co‐IEM)) and poly(benzyl methacrylate‐co‐isocyanatoethyl methacrylate) (P(BnMA‐co‐IEM)), which were synthesized by Cu(0)‐mediated radical polymerization, is reported. Polymerization proceeded to high conversion giving polymers of relatively narrow molar mass distributions. The incorporation of the bulky aromatic groups in the latter copolymer rendered it sufficiently stable toward hydrolysis and enabled the isolation of the product and its characterization by ¹H and ¹³C NMR, and FTIR spectroscopy and SEC. Both P(MMA‐co‐IEM) and P(BnMA‐co‐IEM) were functionalized with dibutylamine, octylamine, and (R)‐(+)‐α‐methylbenzyl‐amine, which further proved the successful incorporation of the isocyanate groups. Furthermore, P(BnMA‐co‐IEM) was used for the fabrication of liquid core microcapsules via oil‐in‐water interfacial polymerization with diethylenetriamine as crosslinker. The particles obtained were in the size range of 10–90 µm in diameter independent of the composition of copolymer. © 2016 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2016 , 54, 2698–2705     

Convergence analysis of modified iterative approaches in geodesic spaces with curvature bounded above

The objective of this article is to establish a new modified iteration process for nonexpansive mappings in complete CAT(κ) spaces. We prove strong and Δ‐convergence theorems of the proposed method in such spaces under some standard conditions. Furthermore, numerical experiments of non‐trivial examples are also provided to show performance and comparison speed of convergence with many previously known methods. Our main result extended and improved the corresponding recent results announced by many researchers.     

Proximal point algorithms for solving convex minimization problem and common fixed points problem of asymptotically quasi-nonexpansive mappings in CAT(0) spaces with convergence analysis

In this paper, we introduce the modified proximal point algorithm for common fixed points of asymptotically quasi-nonexpansive mappings in CAT(0) spaces and also prove some convergence theorems of the proposed algorithm to a common fixed point of asymptotically quasi-nonexpansive mappings and a minimizer of a convex function. The main results in this paper improve and generalize the corresponding results given by some authors. Moreover, we then give numerical examples to illustrate and show efficiency of the proposed algorithm for supporting our main results.     

Preparation of anti-CD4 monoclonal antibody-conjugated magnetic poly(glycidyl methacrylate) particles and their application on CD4+ lymphocyte separation

Novel immunomagnetic particles have been prepared for separation of CD4⁺ lymphocytes. The magnetic nanoparticles with a diameter of approximately 5-6 nm were first synthesized by co-precipitation from ferrous and ferric iron solutions and subsequently encapsulated with poly(glycidyl methacrylate) (PGMA) by precipitation polymerization. Monoclonal antibody specific to CD4 molecules expressed on CD4⁺ lymphocytes was conjugated to the surface of magnetic PGMA particles through covalent bonding between epoxide functional groups on the particle surface and primary amine groups of the antibodies. The generated immunomagnetic particles have successfully separated CD4⁺ lymphocytes from whole blood with over 95% purity. The results indicated that these particles can be employed for cell separation and provide a strong potential to be applied in various biomedical applications including diagnosis, and monitoring of human diseases.