全文获取类型
收费全文 | 93篇 |
免费 | 7篇 |
专业分类
化学 | 62篇 |
力学 | 3篇 |
数学 | 25篇 |
物理学 | 10篇 |
出版年
2022年 | 4篇 |
2021年 | 2篇 |
2020年 | 4篇 |
2019年 | 4篇 |
2018年 | 1篇 |
2017年 | 3篇 |
2016年 | 4篇 |
2015年 | 4篇 |
2014年 | 3篇 |
2013年 | 14篇 |
2012年 | 10篇 |
2011年 | 5篇 |
2010年 | 11篇 |
2009年 | 4篇 |
2008年 | 4篇 |
2007年 | 4篇 |
2006年 | 3篇 |
2005年 | 3篇 |
2004年 | 1篇 |
2003年 | 1篇 |
2002年 | 1篇 |
2000年 | 1篇 |
1999年 | 1篇 |
1998年 | 1篇 |
1996年 | 1篇 |
1994年 | 1篇 |
1987年 | 1篇 |
1983年 | 1篇 |
1979年 | 1篇 |
1977年 | 1篇 |
1974年 | 1篇 |
排序方式: 共有100条查询结果,搜索用时 30 毫秒
1.
Hybrid Laplace transform-finite element method to a generalized electromagneto-thermoelastic problem
A finite element method based on the Laplace transform technique is developed for a two-dimensional problem in electromagneto-thermoelasticity. The problem is in the context of the following generalized thermoelasticity theories: Lord–Shulman’s, Green–Lindsay’s, the Chandrasekharaiah–Tzou, as well as the dynamic coupled theory. The Laplace transform method is applied to the time domain and the resulting equations are discretized using the finite element method. The inversion process is carried out using a numerical method based on a Fourier series expansions. Numerical results compared with those given in literature prove the good performance of the used method. It is demonstrated that the Chandrasekharaiah–Tzou theory can be considered as an extension of Lord–Shulman’s, and the generalized heat conduction mechanism is completely different from the classical Fourier’s in essence. 相似文献
2.
HIV infection leads to progressive alterations of humoral immune functions, including B-cell hyperplasia, hypergammaglobulinemia,
elevated autoantibody titers, a poor response to neoantigens and mitogens, polyclonal B-cell activation, monoclonal gammopathies,
and a significant deterioration of the antigen-specific humoral response. There is also an important isotypic imbalance of
the antibody (Ab) response in the systemic compartment and a profound modification of mucosal immune functions. These abnormalities
may contribute to disease progression and development of opportunistic infections, despite the presence of serum-neutralizing
anti-HIV Abs. Equally important are the abnormal selection mechanisms of the Ab repertoire that seem to be responsible for
B-cell clonal deletions. The VH3 gene family, which encodes for approx 50% of immunoglobulins expressed by peripheral B-cells from normal adults, is underrepresented
in human monoclonal antibodies to HIV-1 and in the peripheral B-cells of AIDS patients. These abnormalities, together with
features of germinal center alteration, could be responsible for the clonal elimination of a subset of B-cells, and could
contribute to HIV pathogenesis. 相似文献
3.
Moncef Cossentini Bernard Deschamps Nguyen Trong Anh Jacqueline Seyden-Penne 《Tetrahedron》1977,33(4):409-412
Reaction of phosphonoester 2 and phosphononitrile 3 with chalcone and p-methoxychaleone in THF-t-BuOK at room temperature gives only the product resulting from CC double bond attack. The same reagents with benzalacetone lead to mixture of products resulting from CC double bond and carbonyl attack, though phosphine oxide 4 gives only the products of CC attack. Dypnone gives products of carbonyl attack with 3 and does not react with 2.These results are discussed in terms of perturbation theory: C4 attack increases with delocalization of the reagent's negative charge and lowering of the α-enone LUMO level. 相似文献
4.
5.
D. P. Singh B. Sirota S. Talpatra P. Kohli C. Rebholz S. M. Aouadi 《Journal of nanoparticle research》2012,14(4):781
Silver molybdate microrods are self-assembled into micron sized, broom-like and flower-like structures. Our investigations
indicate that through a simple hydrothermal process, large scale production of such structure is possible. Using ammonium
molybdate and silver nitrate solutions as precursors, we were able to show that the self assembled architectures were dependent
on the pH of the starting precursor material. To understand the formation and destructions of the flower-like morphology,
a systematic broad range (from acidic to basic) of pH-controlled experiments were performed and its influence on the structure/microstructure
of synthesized materials was investigated. Scanning electron microscopy studies revealed that the morphology and microstructure
of the products varied significantly by changing pH values from 3 to 8 during mixing of the reactants. pH = 3 and 4 resulted
in the self assembly of monoclinic Ag2(Mo2O7) microrods into broom-like structures, whereas pH = 5 resulted into the flower-like morphology of mixed phase of monoclinic
and triclinic Ag2Mo2O7. We also found that increasing the pH after a certain threshold value (for example pH > 6) resulted in total collapse of
the flower-like morphology. Further increase of the pH to 7 and 8 resulted, the formation of microparticles of Ag2MoO4. A tentative scheme based on the pH-driven evolution of the self-assembly has been given to explain the formation of the
observed heterostructures. Preliminary electrical characterization of thin films of the flower-like structures rendered non-linear
current–voltage (I–V) responses. We also observed a strong hysteresis in the I–V responses of the flower-like structures developed
under high bias conditions. 相似文献
6.
A new total synthesis of Otanthus Maritima amide 1 was achieved from 6-trimetylsily N-tert-butyl sorbaldimine 6 in 76% global yield. The natural product 1 was obtained in three steps by condensation of 6 on thiophenal in the presence of catalytic amount of CsF (10%) in DMSO followed by oxidation and amidification of the corresponding intermediate. 相似文献
7.
1,3-Dipolar cycloaddition reactions of a sugar-based trifluoromethylated nitrone-to-maleimide and allyl bromide afforded a series of cycloadducts in good yield. The same nitrone reacts with propargyl acetate lead, after rearrangement of 4-isoxazoline, to aziridine with good yield. The obtained compounds were evaluated for their in vitro antimicrobial potency. Additionally, we are interested in predicting their physicochemical parameters such as lipophilicity and bioactivity score as well as their pharmacokinetic properties such as absorption, distribution, metabolism, and excretion (ADME) such as plasma protein binding (PPB) penetration of the blood–brain barrier (BBB), human intestinal absorption (HIA), cellular permeability (PCaco-2), cell permeability of Madin–Darby canine kidney (PMDCK), P-glycoprotein (P-gp) efflux, CYP inducers, substrates and inhibitors’ skin and permeability (PS), and their toxicological behavior [mutagenicity, carcinogenicity, acute, environmental, cardiotoxicity (hERG inhibition)] using in silico computational methods. Also, we aimed to validate QSAR models for the elucidation of their antitarget using 32 sets of end-points (IC50, Ki and Kact). The obtained result provides good information about the pharmacotherapy potential and toxicity of the examined molecules with good compliance between in vitro antimicrobial and the predicted properties. Findings indicated and encouraged the use of these compounds and their derivatives for further in vivo evaluations in the design and the elucidation of the intrinsic mechanisms as well as the efficacy of the selected powerful drug. 相似文献
8.
In this Note, we prove a theorem on the extension of a negative (or positive) plurisubharmonic current T (i.e. such that ) with condition on the slices with respect to some coordinates. This theorem generalizes a result proved by El Mir–Ben Messaoud relative to d-closed positive currents with a condition on slices. The method consists first of proving a Chern–Levine–Nirenberg inequality for a positive (or negative) psh current, which is a generalization of results obtained by Bedford–Taylor, Demailly and Sibony for d-closed positive currents. Also we prove an Oka type inequality for positive psh currents, thereby generalizing former results by Ben Messaoud–El Mir concerning positive currents with a negative . To cite this article: M. Toujani, H. Ben Messaoud, C. R. Acad. Sci. Paris, Ser. I 339 (2004). 相似文献
9.
10.
Nahed Fakhfakh-Zouari Noomen Hmidet Anissa Haddar Safia Kanoun Moncef Nasri 《Applied biochemistry and biotechnology》2010,162(2):329-344
A keratinolytic enzyme (KerA1) secreted by a newly isolated Bacillus pumilus strain A1 cultivated in medium containing chicken feather meal was purified and characterized, and the gene was isolated
and sequenced. The molecular mass of the purified enzyme was estimated to be 34,000 Da by sodium dodecyl sulfate (SDS) polyacrylamide
gel electrophoresis and gel filtration. The optimum pH and temperature for the purified keratinase were 9.0 and 60 °C, respectively,
using keratin as a substrate. KerA1 showed a high stability towards nonionic surfactants. It was found to be relatively stable
toward the strong anionic surfactant (SDS). The deduced amino acid sequence of the keratinase KerA1 differs from both the
organic solvent tolerant protease of B. pumilus 115b and the dehairing protease of B. pumilus UN-31-C-42 by one and nine amino acids, respectively. These results suggest that this keratinase may be a useful alternative
and ecofriendly route for handling the abundant amount of waste feathers and for applications in detergent formulations. 相似文献