Effect of photothermal therapy on breast tumor vascular contents: noninvasive monitoring by near-infrared spectroscopy

The goal of this study was to investigate the effect of photothermal laser irradiation on rat breast tumor (DMBA-4) vascular contents. An 805-nm diode laser was used in our experiment with a power density ranging from 0.32 to 1.27 W/cm2. The dynamic changes of oxygenated hemoglobin and total hemoglobin concentrations, delta[HbO2] and delta[Hb]total, in rat tumors during photothermal irradiation were noninvasively monitored by a near-infrared spectroscopy system. A multichannel thermal detection system was also used simultaneously to record temperatures at different locations within the tumors. Our experimental results showed that: (1) photoirradiation did have the ability to induce hyperthermic effects inside the rat breast tumors in a single exponential trend; (2) the significant changes (P < 0.005) of delta[HbO2] and delta[Hb]total in response to a low dosage of laser irradiation (0.32 W/cm2) have a single exponential increasing trend, similar to that seen in the tumor interior temperature; and (3) the increase in magnitude of delta[HbO2] is nearly two times greater than that of delta[Hb]total, suggesting that photoirradiation may enhance tumor vascular oxygenation. The last observation may be important to reveal the hidden mechanism of photoirradiation on tumors, leading to improvement of tumor treatment efficiency.     

A globally convergent numerical method for an inverse elliptic problem of optical tomography

A new globally convergent numerical method is developed for an inverse problem for the elliptic equation with the unknown potential. The boundary data simulating measurements in optical tomography are generated by the running source. Global convergence analysis is presented along with numerical experiments.     

Equivalence of Sharp Trudinger-Moser Inequalities in Lorentz-Sobolev Spaces

Potential Analysis - The critical and subcritical Trudinger-Moser inequalities in Lorentz Sobolev space have been studied by Cassani and Tarsi (Asymptot. Anal. 64(1-2):29–51, 2009), Lu and...     

New Alkaloids from Aconitum vaginatum

Two new amide alkaloids, vaginatunine A and B ( 1 and 2 , resp.), and a new C₁₈‐diterpenoid alkaloid vaginatunine C ( 3 ), together with four known alkaloids, were isolated from the tubers of Aconitum vaginatum. Their structures were determined by means of spectroscopic analyses and comparison of the data with those reported previously.     

Sharp Affine and Improved Moser–Trudinger–Adams Type Inequalities on Unbounded Domains in the Spirit of Lions

The purpose of this paper is threefold. First, we prove sharp singular affine Moser–Trudinger inequalities on both bounded and unbounded domains in \({\mathbb {R}}^{n}\). In particular, we will prove the following much sharper affine Moser–Trudinger inequality in the spirit of Lions (Rev Mat Iberoamericana 1(2):45–121, 1985) (see our Theorem 1.4): Let \(\alpha _{n}=n\left( \frac{n\pi ^{\frac{n}{2}}}{\Gamma (\frac{n}{2}+1)}\right) ^{\frac{1}{n-1}}\), \(0\le \beta <n\) and \(\tau >0\). Then there exists a constant \(C=C\left( n,\beta \right) >0\) such that for all \(0\le \alpha \le \left( 1-\frac{\beta }{n}\right) \alpha _{n}\) and \(u\in C_{0}^{\infty }\left( {\mathbb {R}}^{n}\right) \setminus \left\{ 0\right\} \) with the affine energy \(~{\mathcal {E}}_{n}\left( u\right) <1\), we have

$$\begin{aligned} {\displaystyle \int \nolimits _{{\mathbb {R}}^{n}}} \frac{\phi _{n,1}\left( \frac{2^{\frac{1}{n-1}}\alpha }{\left( 1+{\mathcal {E}}_{n}\left( u\right) ^{n}\right) ^{\frac{1}{n-1}}}\left| u\right| ^{\frac{n}{n-1}}\right) }{\left| x\right| ^{\beta }}dx\le C\left( n,\beta \right) \frac{\left\| u\right\| _{n}^{n-\beta }}{\left| 1-{\mathcal {E}}_{n}\left( u\right) ^{n}\right| ^{1-\frac{\beta }{n}}}. \end{aligned}$$

Moreover, the constant \(\left( 1-\frac{\beta }{n}\right) \alpha _{n}\) is the best possible in the sense that there is no uniform constant \(C(n, \beta )\) independent of u in the above inequality when \(\alpha >\left( 1-\frac{\beta }{n}\right) \alpha _{n}\). Second, we establish the following improved Adams type inequality in the spirit of Lions (Theorem 1.8): Let \(0\le \beta <2m\) and \(\tau >0\). Then there exists a constant \(C=C\left( m,\beta ,\tau \right) >0\) such that

$$\begin{aligned} \underset{u\in W^{2,m}\left( {\mathbb {R}}^{2m}\right) , \int _{ {\mathbb {R}}^{2m}}\left| \Delta u\right| ^{m}+\tau \left| u\right| ^{m} \le 1}{\sup } {\displaystyle \int \nolimits _{{\mathbb {R}}^{2m}}} \frac{\phi _{2m,2}\left( \frac{2^{\frac{1}{m-1}}\alpha }{\left( 1+\left\| \Delta u\right\| _{m}^{m}\right) ^{\frac{1}{m-1}}}\left| u\right| ^{\frac{m}{m-1}}\right) }{\left| x\right| ^{\beta }}dx\le C\left( m,\beta ,\tau \right) , \end{aligned}$$

for all \(0\le \alpha \le \left( 1-\frac{\beta }{2m}\right) \beta (2m,2)\). When \(\alpha >\left( 1-\frac{\beta }{2m}\right) \beta (2m,2)\), the supremum is infinite. In the above, we use

$$\begin{aligned} \phi _{p,q}(t)=e^{t}- {\displaystyle \sum \limits _{j=0}^{j_{\frac{p}{q}}-2}} \frac{t^{j}}{j!},\,\,\,j_{\frac{p}{q}}=\min \left\{ j\in {\mathbb {N}} :j\ge \frac{p}{q}\right\} \ge \frac{p}{q}. \end{aligned}$$

The main difficulties of proving the above results are that the symmetrization method does not work. Therefore, our main ideas are to develop a rearrangement-free argument in the spirit of Lam and Lu (J Differ Equ 255(3):298–325, 2013; Adv Math 231(6): 3259–3287, 2012), Lam et al. (Nonlinear Anal 95: 77–92, 2014) to establish such theorems. Third, as an application, we will study the existence of weak solutions to the biharmonic equation

$$\begin{aligned} \left\{ \begin{array}{l} \Delta ^{2}u+V(x)u=f(x,u)\text { in }{\mathbb {R}}^{4}\\ u\in H^{2}\left( {\mathbb {R}}^{4}\right) ,~u\ge 0 \end{array} \right. , \end{aligned}$$

where the nonlinearity f has the critical exponential growth.

     

无限元与相同子结构串的一致性及其算法

讨论了无限元方法￣［１］与相同子结构串分析￣［２］的一致性，综合文［１］和［２］得到一种通用算法，依据文［３］尚可应用于ＬＱ控制问题，且提出一种直接求出转移矩阵的算法，具有简便和较高精度的优点．     

Sharp Moser–Trudinger Inequalities on Hyperbolic Spaces with Exact Growth Condition

Let \(\Phi _{n}(x)=e^x-\sum _{j=0}^{n-2}\frac{x^j}{j!}\) and \(\alpha _{n} =n\omega _{n-1}^{\frac{1}{n-1}}\) be the sharp constant in Moser’s inequality (where \(\omega _{n-1}\) is the area of the surface of the unit \(n\)-ball in \(\mathbb {R}^n\)), and \(dV\) be the volume element on the \(n\)-dimensional hyperbolic space \((\mathbb {H}^n, g)\) (\(n\ge {2}\)). In this paper, we establish the following sharp Moser–Trudinger type inequalities with the exact growth condition on \(\mathbb {H}^n\):

For any \(u\in {W^{1,n}(\mathbb {H}^n)}\) satisfying \(\Vert \nabla _{g}u\Vert _{n}\le {1}\), there exists a constant \(C(n)>0\) such that

$$\begin{aligned} \int _{\mathbb {H}^n}\frac{\Phi _{n}(\alpha _{n}|u|^{\frac{n}{n-1}})}{(1+|u|)^{\frac{n}{n-1}}}dV \le {C(n)\Vert u\Vert _{L^n}^{n}}. \end{aligned}$$

The power \(\frac{n}{n-1}\) and the constant \(\alpha _{n}\) are optimal in the following senses:

1. (i)
   If the power \(\frac{n}{n-1}\) in the denominator is replaced by any \(p<\frac{n}{n-1}\), then there exists a sequence of functions \(\{u_{k}\}\) such that \(\Vert \nabla _{g}u_{k}\Vert _{n}\le {1}\), but

   $$\begin{aligned} \frac{1}{\Vert u_{k}\Vert _{L^n}^{n}}\int _{\mathbb {H}^n} \frac{\Phi _{n}(\alpha _{n}(|u_{k}|)^{\frac{n}{n-1}})}{(1+|u_{k}|)^{p}}dV \rightarrow {\infty }. \end{aligned}$$
    
2. (ii)
   If \(\alpha >\alpha _{n}\), then there exists a sequence of function \(\{u_{k}\}\) such that \(\Vert \nabla _{g}u_{k}\Vert _{n}\le {1}\), but

   $$\begin{aligned} \frac{1}{\Vert u_{k}\Vert _{L^n}^{n}}\int _{\mathbb {H}^n} \frac{\Phi _{n}(\alpha (|u_{k}|)^{\frac{n}{n-1}})}{(1+|u_{k}|)^{p}}dV\rightarrow {\infty }, \end{aligned}$$

   for any \(p\ge {0}\).
    

This result sharpens the earlier work of the authors Lu and Tang (Adv Nonlinear Stud 13(4):1035–1052, 2013) on best constants for the Moser–Trudinger inequalities on hyperbolic spaces.

     

Synthesis,characterization, and antimicrobial activity of novel heterocyclic compounds containing a ferrocene unit via Michael addition reaction

Research on Chemical Intermediates - A series of novel heterocyclic compounds containing a ferrocene unit were synthesized by reacting ferrocenylchalcone with pyrazolyl amine or triazolyl amine via...     

Hybrid inorganic/organic crosslinked resins containing polyhedral oligomeric silsesquioxanes

The incorporation of both monofunctional and multifunctional polyhedral oligomeric silsesquioxane (POSS) derivatives into crosslinked resins has been conducted as a route to synthesize hybrid organic/inorganic nanocomposites. The central cores of POSS molecules contain an inorganic cage with (SiO_1.5)_n stoichiometry where n=8,10 and 12. Each Si atom is capped with one H or R function giving an organic outer shell surrounding the nanometer-sized inorganic inner cage. By including polymerizable functions on the R groups, a hybrid organic/inorganic macromer is obtained which can be copolymerized with organic monomers to create thermoplastic or thermoset systems. We have focused on incorporating POSS derivatives into crosslinking resins of the following types: (1) dicyclopentadiene (2) epoxies (3) vinyl esters (4) styrene-DVB (5) MMA/1,4-butane dimethacrylate (6) phenolics and (7) cyanate esters. One goal has been to determine if molecular dispersion of the POSS macromers has been achieved or if various degrees of aggregation occur during crosslinked resin formation. As network formation proceeds, a kinetic race between POSS molecular incorporation into the network versus phase separation into POSS-rich regions (which then polymerize) occurs. Ultimately, we hope to determine the effects of such microstructural features on properties. Combustion of these hybrids creates a SiO₂-like surface layer that retards flame spread. Dynamic mechanical properties have been studied.